N-methyl-D-aspartic acid increases tight junction protein destruction in brain endothelial cell via caveolin-1-associated ERK1/2 signaling

Abdelmohsen, 2008, Posttranscriptional gene regulation by RNA-binding proteins during oxidative stress: implications for cellular senescence, Biol Chem, 389, 243, 10.1515/BC.2008.022 Andras, 2007, The NMDA and AMPA/KA receptors are involved in glutamate-induced alterations of occludin expression and phosphorylation in brain endothelial cells, J Cereb Blood Flow Metab, 27, 1431, 10.1038/sj.jcbfm.9600445 Bernstein, 2020, miR-98 reduces endothelial dysfunction by protecting blood-brain barrier (BBB) and improves neurological outcomes in mouse ischemia/reperfusion stroke model, J Cereb Blood Flow Metab, 40, 1953, 10.1177/0271678X19882264 Bersier, 2008, The Expression of NMDA Receptor Subunits in Cerebral Cortex and Hippocampus is Differentially Increased by Administration of Endobain E, a Na, K+-ATPase Inhib, 33, 66 Chen, 2016, Roles of NMDARs in maintenance of the mouse cerebrovascular endothelial cell-constructed tight junction barrier, Toxicology, 339, 40, 10.1016/j.tox.2015.11.006 Dar, 2017, Withanone, an Active Constituent from Withania somnifera, Affords Protection Against NMDA-Induced Excitotoxicity in Neuron-Like Cells, Mol Neurobiol, 54, 5061, 10.1007/s12035-016-0044-7 Fernandez-Rojo, 2016, Caveolin-1 Funct Liver Physiol Dis, 889 Ge, 2020, NMDARs in Cell Survival and Death: Implications in Stroke Pathogenesis and Treatment, Trends Mol Med, 26, 533, 10.1016/j.molmed.2020.03.001 Gonda, 2012, Basic Pharmacology of NMDA Receptors, Curr Pharm Des, 18, 1558, 10.2174/138161212799958521 Head, 2011, Neuron-targeted caveolin-1 protein enhances signaling and promotes arborization of primary neurons, J Biol Chem, 286, 33310, 10.1074/jbc.M111.255976 Jiang, 2017, HIV-1 Transactivator Protein Induces ZO-1 and Neprilysin Dysfunction in Brain Endothelial Cells via the Ras Signaling Pathway, Oxid Med Cell Longev, 2017, 3160360, 10.1155/2017/3160360 Jin, 2011, Caveolin-1: a critical regulator of lung injury, Am J Physiol Lung Cell Mol Physiol, 300, L151, 10.1152/ajplung.00170.2010 Kisler, 2017, Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease, Nat Rev Neurosci, 18, 419, 10.1038/nrn.2017.48 Lamaze, 2017, The caveolae dress code: structure and signaling, Curr Opin Cell Biol, 47, 117, 10.1016/j.ceb.2017.02.014 Li, 2020, Gut microbiota regulate cognitive deficits and amyloid deposition in a model of Alzheimer's disease, J Neurochem, 155, 448, 10.1111/jnc.15031 Masahiko, 1999, Direct Binding of Three Tight Junction-associated MAGUKs, ZO-1, ZO-2,and ZO-3, with the COOH Termini of Claudins, J Cell Biol, 1351 Mehra, 2020, Nonionotropic Action of Endothelial NMDA Receptors on Blood-Brain Barrier Permeability via Rho/ROCK-Mediated Phosphorylation of Myosin, J Neurosci, 40, 1778, 10.1523/JNEUROSCI.0969-19.2019 Niu, 2019, Aberrant oligodendroglial-vascular interactions disrupt the blood-brain barrier, triggering CNS inflammation, Nat Neurosci, 22, 709, 10.1038/s41593-019-0369-4 Obermeier, 2013, Development, maintenance and disruption of the blood-brain barrier, Nat Med, 19, 1584, 10.1038/nm.3407 Parton, 2013, Caveolae as plasma membrane sensors, protectors and organizers, Nat Rev Mol Cell Biol, 14, 98, 10.1038/nrm3512 Pu, 2005, HIV-1 Tat protein-induced alterations of ZO-1 expression are mediated by redox-regulated ERK 1/2 activation, J Cereb Blood Flow Metab, 25, 1325, 10.1038/sj.jcbfm.9600125 Razani, 2021, Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities, J Biol Chem, 276, 37731 Ryoo, 2020, Ginsenoside Rk1 is a novel inhibitor of NMDA receptors in cultured rat hippocampal neurons, J Ginseng Res, 44, 490, 10.1016/j.jgr.2019.04.002 Sarkaria, 2018, Is the blood-brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data, Neuro Oncol, 20, 184, 10.1093/neuonc/nox175 Sharp, 2003, Glutamate causes a loss in human cerebral endothelial barrier integrity through activation of NMDA receptor, Am J Physiol Heart Circ Physiol, 285, H2592, 10.1152/ajpheart.00520.2003 Shi, 2016, Rapid endothelial cytoskeletal reorganization enables early blood-brain barrier disruption and long-term ischaemic reperfusion brain injury, Nat Commun, 7, 10523, 10.1038/ncomms10523 Sotgia, 2012, Caveolin-1 and cancer metabolism in the tumor microenvironment: markers, models, and mechanisms, Annu Rev Pathol, 7, 423, 10.1146/annurev-pathol-011811-120856 Stamatovic, 2016, Junctional proteins of the blood-brain barrier: New insights into function and dysfunction, Tissue Barriers, 4, 10.1080/21688370.2016.1154641 Sweeney, 2018, Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders, Nat Rev Neurol, 14, 133, 10.1038/nrneurol.2017.188 Vazana, 2016, Glutamate-Mediated Blood-Brain Barrier Opening: Implications for Neuroprotection and Drug Delivery, J Neurosci, 36, 7727, 10.1523/JNEUROSCI.0587-16.2016 Wang, 2010, Diphtheria toxin mutant CRM197-mediated transcytosis across blood-brain barrier in vitro, Cell Mol Neurobiol, 30, 717, 10.1007/s10571-010-9496-x Wu, 2020, Polydatin protects against lipopolysaccharide-induced endothelial barrier disruption via SIRT3 activation, Lab Invest, 100, 643, 10.1038/s41374-019-0332-8 Xia, 2021, 2-(2-Benzofuranyl)-2-Imidazoline Attenuates the Disruption of the Blood-Brain Barrier in EAE via NMDAR, Neurochem Res, 46, 1674, 10.1007/s11064-021-03304-2 Yang, 2015, Caveolin-1 in the anterior cingulate cortex modulates chronic neuropathic pain via regulation of NMDA receptor 2B subunit, J Neurosci, 35, 36, 10.1523/JNEUROSCI.1161-14.2015 Yang, 2018, Humanin Attenuates NMDA-Induced Excitotoxicity by Inhibiting ROS-dependent JNK/p38 MAPK Pathway, Int J Mol Sci, 19, 2982, 10.3390/ijms19102982 Yin, 2017, Caveolin proteins: a molecular insight into disease, Front Med, 10, 397, 10.1007/s11684-016-0483-6 Yu, 2022, NMDA mediates disruption of blood-brain barrier permeability via Rho/ROCK signaling pathway, Neurochem Int, 154, 10.1016/j.neuint.2022.105278 Zhang, 2019, Caveolin-1 promotes invasion and metastasis by upregulating Pofut1 expression in mouse hepatocellular carcinoma, Cell Death Dis, 10, 477, 10.1038/s41419-019-1703-1 Zhang, 2019, Caveolin-1 promotes Rfng expression via Erk-Jnk-p38 signaling pathway in mouse hepatocarcinoma cells, J Physiol Biochem, 75, 549, 10.1007/s13105-019-00703-6 Zhang, 2018, Autophagy- and MMP-2/9-mediated Reduction and Redistribution of ZO-1 Contribute to Hyperglycemia-increased Blood-Brain Barrier Permeability During Early Reperfusion in Stroke, Neuroscience, 377, 126, 10.1016/j.neuroscience.2018.02.035 Zou, 2019, Role of Cav-1 in HIV-1 Tat-Induced Dysfunction of Tight Junctions and Abeta-Transferring Proteins, Oxid Med Cell Longev, 2019, 3403206, 10.1155/2019/3403206