N-acyl Taurines and Acylcarnitines Cause an Imbalance in Insulin Synthesis and Secretion Provoking β Cell Dysfunction in Type 2 Diabetes

Cell Metabolism - Tập 25 - Trang 1334-1347.e4 - 2017
Michaela Aichler1, Daniela Borgmann1, Jan Krumsiek2,3, Achim Buck1, Patrick E. MacDonald4,5, Jocelyn E. Manning Fox4,5, James Lyon4, Peter E. Light4,5, Susanne Keipert3,6, Martin Jastroch3,6, Annette Feuchtinger1, Nikola S. Mueller2, Na Sun1, Andrew Palmer7, Theodore Alexandrov7,8,9, Martin Hrabe de Angelis3,10,11, Susanne Neschen3,10, Matthias H. Tschöp3,6,12, Axel Walch1
1Research Unit Analytical Pathology, Helmholtz Zentrum München, Neuherberg 85764, Germany
2Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg 85764, Germany
3German Center for Diabetes Research (DZD), Ingolstädter Landstr. 1, Neuherberg 85764, Germany
4Alberta Diabetes Institute, University of Alberta, Edmonton T6G 2E1, Canada
5Department of Pharmacology, University of Alberta, Edmonton T6G 2E1, Canada
6Institute for Diabetes and Obesity, Helmholtz Zentrum München, Neuherberg 85764, Germany
7Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg 69117, Germany
8Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA
9SCiLS GmbH, 28359 Bremen, Germany;
10Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstrasse 1, Neuherberg 85764, Germany
11Chair of Experimental Genetics, School of Life Science Weihenstephan, Technische Universität München, Alte Akademie 8, 85354 Freising, Germany
12Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 80333 Munich, Germany

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