N-Methyl-d-Aspartate Receptor Agonism and Antagonism Within the Amygdaloid Central Nucleus Suppresses Pain Affect: Differential Contribution of the Ventrolateral Periaqueductal Gray

Behbehani, 1990, The effect of [Met]enkephalin on the periaqueductal gray neurons of the rat: an in vitro study, Neuroscience, 38, 373, 10.1016/0306-4522(90)90035-3 Bernard, 1990, The spino(trigemino)pontoamygdaloid pathway: Electrophysiological evidence for an involvement in pain processes, J Neurophysiol, 63, 473, 10.1152/jn.1990.63.3.473 Bernard, 1992, Nucleus centralis of the amygdala and the globus pallidus ventralis: Electrophysiological evidence for an involvement in pain processes, J Neurophysiol, 68, 551, 10.1152/jn.1992.68.2.551 Bird, 2005, Protein kinase A-dependent enhanced NMDA receptor function in pain-related synaptic plasticity in rat amygdala neurones, J Physiol, 564, 907, 10.1113/jphysiol.2005.084780 Bodnar, 2000, Supraspinal circuitry mediating opioid antinociception: Antagonist and synergy studies in multiple sites, J Biomed Sci, 7, 181, 10.1007/BF02255465 Borszcz, 1993, The capacity of motor reflex and vocalization thresholds to support avoidance conditioning in the rat, Behav Neurosci, 107, 678, 10.1037/0735-7044.107.4.678 Borszcz, 1995, Pavlovian conditional vocalizations of the rat: A model system for analyzing the fear of pain, Behav Neurosci, 109, 648, 10.1037/0735-7044.109.4.648 Borszcz, 1999, Differential contributions of medullary, thalamic, and amygdaloid serotonin to the antinociceptive action of morphine administered into the periaqueductal gray: A model of morphine analgesia, Behav Neurosci, 113, 612, 10.1037/0735-7044.113.3.612 Borszcz, 2006, Contribution of the ventromedial hypothalamus to generation of the affective dimension of pain, Pain, 123, 155, 10.1016/j.pain.2006.02.026 Borszcz, 2000, Amygdaloid-thalamic interactions mediate the antinociceptive action of morphine microinjected into the periaqueductal gray, Behav Neurosci, 114, 574, 10.1037/0735-7044.114.3.574 Borszcz, 2003, The effect of amygdala lesions on conditional and unconditional vocalizations in rats, Neurobiol Learn Mem, 79, 212, 10.1016/S1074-7427(03)00002-9 Borszcz, 2009, Hypothalamic control of pain vocalization and affective dimension of pain signaling, 281 Borszcz, 1994, Comparison of motor reflex and vocalization thresholds following systemically administered morphine, fentanyl, and diazepam in the rat: Assessment of sensory and performance variables, Pharmacol Biochem Behav, 49, 827, 10.1016/0091-3057(94)90230-5 Borszcz, 1996, The differential contribution of spinopetal projections to increases in vocalization and motor reflex thresholds generated by the microinjection of morphine into the periaqueductal gray, Behav Neurosci, 110, 368, 10.1037/0735-7044.110.2.368 Borszcz, 1992, Characterization of tailshock elicited withdrawal reflexes in intact and spinal rats, Physiol Behav, 52, 1055, 10.1016/0031-9384(92)90459-F Bourbia, 2014, Descending effect on spinal nociception by amygdaloid glutamate varies with the submodality of noxious test stimulation, Neurosci Lett, 570, 26, 10.1016/j.neulet.2014.04.010 Brown, 1977, Limbic target surgery in the treatment of intractable pain with drug addiction, 661 Burstein, 1993, Retrograde labeling of neurons in the spinal cord that project directly to the amygdala or the orbital cortex in the rat, J Comp Neurol, 335, 469, 10.1002/cne.903350402 Butler, 2009, Stress-induced analgesia, Prog Neurobiol, 88, 184, 10.1016/j.pneurobio.2009.04.003 Carroll, 1960, Observations on the neuropharmacology of morphine and morphinelike analgesia, Arch Int Pharmacodyn Ther, 125, 383 Cassell, 1999, The intrinsic organization of the central extended amygdala, Ann N Y Acad Sci, 877, 217, 10.1111/j.1749-6632.1999.tb09270.x Chapman, 2008, Pain and stress in a systems perspective: Reciprocal neural, endocrine, and immune interactions, J Pain, 9, 122, 10.1016/j.jpain.2007.09.006 Cho, 2003, Pain dynamics observed by functional magnetic resonance imaging: Differential regression analysis technique, J Magn Reson Imaging, 18, 273, 10.1002/jmri.10368 da Costa Gomez, 1995, An electrophysiological characterization of the projection from the central nucleus of the amygdala to the periaqueductal gray of the rat: The role of opioid receptors, Brain Res, 689, 21, 10.1016/0006-8993(95)00525-U Fanselow, 1985, Odors released by stressed rats produce opioid analgesia in unstressed rats, Behav Neurosci, 99, 589, 10.1037/0735-7044.99.3.589 Farb, 1995, Differential localization of NMDA and AMPA receptor subunits in the lateral and basal nuclei of the amygdala: A light and electron microscopic study, J Comp Neurol, 362, 86, 10.1002/cne.903620106 Frenk, 1981, Effects of amygdaloid kindling on the pain threshold of the rat, Exp Neurol, 71, 487, 10.1016/0014-4886(81)90026-1 Gracely, 1978, Validity and sensitivity of ratio scales of sensory and affective verbal pain descriptors: Manipulation of affect by diazepam, Pain, 5, 19, 10.1016/0304-3959(78)90021-0 Gracy, 1995, Comparative ultrastructural localization of the NMDAR1 glutamate receptor in the rat basolateral amygdala and bed nucleus of the stria terminalis, J Comp Neurol, 362, 71, 10.1002/cne.903620105 Gray, 1992, Peptide immunoreactive neurons in the amygdala and the bed nucleus of the stria terminalis project to the midbrain central gray in the rat, Peptides, 13, 451, 10.1016/0196-9781(92)90074-D Hamlin, 2007, Induction of c-Fos and zif268 in the nociceptive amygdala parallel abstinence hyperalgesia in rats briefly exposed to morphine, Neuropharmacology, 53, 330, 10.1016/j.neuropharm.2007.05.017 Harte, 2000, Antinociceptive effects of morphine injected into the nucleus parafascicularis thalami of the rat, Brain Res, 874, 78, 10.1016/S0006-8993(00)02583-X Harte, 2005, Activation of 5-HT1A and 5-HT7 receptors in the parafascicular nucleus suppresses the affective reaction of rats to noxious stimulation, Pain, 113, 405, 10.1016/j.pain.2004.11.023 Harte, 2011, Functional interaction between medial thalamus and rostral anterior cingulate cortex in the suppression of pain affect, Neuroscience, 172, 460, 10.1016/j.neuroscience.2010.10.055 Hayashi, 2009, Intracerebroventricular fluvoxamine administration inhibited pain behavior but increased Fos expression in affective pain pathways, Pharmacol Biochem Behav, 91, 441, 10.1016/j.pbb.2008.08.029 Hebben, 1985, Diminished ability to interpret and report internal states after bilateral medial temporal lobe resection. Case H.M, Behav Neurosci, 29, 1031, 10.1037/0735-7044.99.6.1031 Hoffmeister, 1968, Effects of psychotropic drugs on pain, 309 Hsieh, 1996, Traumatic nociceptive pain activates the hypothalamus and the periaqueductal gray: A positron emission tomography study, Pain, 64, 303, 10.1016/0304-3959(95)00129-8 Huber, 2005, Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala, Science, 308, 245, 10.1126/science.1105636 Inada, 2007, Assessment of NMDA receptor activation in vivo by Fos induction after challenge with the direct NMDA agonist (tetrazol-5-yl)glycine: Effects of clozapine and haloperidol, J Neural Transm, 114, 899, 10.1007/s00702-007-0628-5 Jasmin, 1997, Transneuronal labeling of a nociceptive pathway, the spino-(trigemino-)parabrachio-amygdaloid, in the rat, J Neurosci, 17, 3751, 10.1523/JNEUROSCI.17-10-03751.1997 Jelasic, 1966, Relation of the lateral part of the amygdala to pain, Confin Neurol, 27, 53, 10.1159/000103931 Kulkarni, 2005, Attention to pain localization and unpleasantness discriminates the functions of the medial and lateral pain systems, Eur J Neurosci, 21, 3133, 10.1111/j.1460-9568.2005.04098.x LeDoux, 2000, Emotion circuits in the brain, Annu Rev Neurosci, 23, 155, 10.1146/annurev.neuro.23.1.155 Leite-Panissi, 2003, The cholinergic stimulation of the central amygdala modifying the tonic immobility response and antinociception in guinea pigs depends on the ventrolateral periaqueductal gray, Brain Res Bull, 60, 167, 10.1016/S0361-9230(03)00031-5 Li, 2004, Block of NMDA and non-NMDA receptor activation results in reduced background and evoked activity of central amygdala neurons in a model of arthritic pain, Pain, 110, 112, 10.1016/j.pain.2004.03.015 Liu, 2010, Painful stimuli evoke potentials recorded from the medial temporal lobe in humans, Neuroscience, 165, 1402, 10.1016/j.neuroscience.2009.11.026 Loeser, 2000, Pain and suffering, Clin J Pain, 16, S2, 10.1097/00002508-200006001-00002 Maisonnette, 1996, Effects of lesions of amygdaloid nuclei and substantia nigra on aversive responses induced by electrical stimulation of the inferior colliculus, Brain Res Bull, 40, 93, 10.1016/0361-9230(95)02136-1 Mark, 1961, Correlation of pain relief, sensory loss, and anatomical lesion sites in pain patients treated with stereotactic thalamotomy, Trans Am Neurol Assoc, 86, 86 Mena, 1995, Amygdalar involvement in pain, Indian J Physiol Pharmacol, 39, 339 Munn, 2009, Contribution of the periaqueductal gray to the suppression of pain affect produced by administration of morphine into the intralaminar thalamus of rat, J Pain, 10, 426, 10.1016/j.jpain.2008.10.011 Nakagawa, 2003, Differential patterns of c-fos mRNA expression in the amygdaloid nuclei induced by chemical somatic and visceral noxious stimuli in rats, Neurosci Lett, 344, 197, 10.1016/S0304-3940(03)00465-8 Nandigama, 2003, Affective analgesia following the administration of morphine into the amygdala of rats, Brain Res, 959, 343, 10.1016/S0006-8993(02)03884-2 Neugebauer, 2004, The amygdala and persistent pain, Neuroscientist, 10, 221, 10.1177/1073858403261077 Newman, 1996, Direct spinal projections to limbic and striatal areas: anterograde transport studies from the upper cervical spinal cord and the cervical enlargement in squirrel monkey and rat, J Comp Neurol, 365, 640, 10.1002/(SICI)1096-9861(19960219)365:4<640::AID-CNE10>3.0.CO;2-L Ogden, 2011, New advances in NMDA receptor pharmacology, Trends Pharmacol Sci, 32, 726, 10.1016/j.tips.2011.08.003 Ottersen, 1979, Afferent connections to the amygdaloid complex of the rat and cat, J Comp Neurol, 187, 401, 10.1002/cne.901870209 Pavlovic, 1996, Opioid antagonists in the periaqueductal gray inhibit morphine and beta-endorphin analgesia elicited from the amygdala of rats, Brain Res, 741, 13, 10.1016/S0006-8993(96)00880-3 Paxinos, 1998 Price, 1985, A psychophysical analysis of morphine analgesia, Pain, 22, 261, 10.1016/0304-3959(85)90026-0 Radulovic, 2000, In vivo NMDA/dopamine interaction resulting in Fos production in the limbic system and basal ganglia of the mouse brain, Brain Res Mol Brain Res, 75, 271, 10.1016/S0169-328X(99)00322-8 Risgaard, 2010, Partial agonists and subunit selectivity at NMDA receptors, Chemistry, 16, 13910, 10.1002/chem.201001366 Rizvi, 1991, Connections between the central nucleus of the amygdala and the midbrain periaqueductal gray: Topography and reciprocity, J Comp Neurol, 303, 121, 10.1002/cne.903030111 Sandkuhler, 1989, Blockade of GABAA receptors in the midbrain periaqueductal gray abolishes nociceptive spinal dorsal horn neuronal activity, Eur J Pharmacol, 160, 163, 10.1016/0014-2999(89)90667-5 Schneider, 2001, Subjective ratings of pain correlate with subcortical-limbic blood flow: An fMRI study, Neuropsychobiology, 43, 175, 10.1159/000054887 Siegel, 2005 Spuz, 2012, NMDA or non-NMDA receptor antagonism within the amygdaloid central nucleus suppresses the affective dimension of pain in rats: Evidence for hemispheric synergy, J Pain, 13, 328, 10.1016/j.jpain.2011.12.007 Stutzmann, 1999, GABAergic antagonists block the inhibitory effects of serotonin in the lateral amygdala: A mechanism for modulation of sensory inputs related to fear conditioning, J Neurosci, 19, RC8, 10.1523/JNEUROSCI.19-11-j0005.1999 Stutzmann, 1998, Serotonin modulation of sensory inputs to the lateral amygdala: Dependency on corticosterone, J Neurosci, 18, 9529, 10.1523/JNEUROSCI.18-22-09529.1998 Sweet, 1980, Central mechanisms of chronic pain (neuralgias and certain other neurogenic pain), 287 Tanimoto, 2003, Differential contributions of the basolateral and central nuclei of the amygdala in the negative affective component of chemical somatic and visceral pains in rats, Eur J Neurosci, 18, 2343, 10.1046/j.1460-9568.2003.02952.x Tershner, 2000, Antinociception produced by mu opioid receptor activation in the amygdala is partly dependent on activation of mu opioid and neurotensin receptors in the ventral periaqueductal gray, Brain Res, 865, 17, 10.1016/S0006-8993(00)02179-X Volz, 1990, Afferent connections of the nucleus centralis amygdalae. A horseradish peroxidase study and literature survey, Anat Embryol (Berl), 181, 177, 10.1007/BF00198957 Zubieta, 2001, Regional mu opioid receptor regulation of sensory and affective dimensions of pain, Science, 293, 311, 10.1126/science.1060952