N-Acetylaspartylglutamate (NAAG) and N-Acetylaspartate (NAA) in Patients With Schizophrenia

Schizophrenia Bulletin - Tập 39 Số 1 - Trang 197-205 - 2013
Frank Jessen1,2, Natascha Fingerhut1, Alois M. Sprinkart3, Kai‐Uwe Kühn4, Nadine Petrovsky1, Wolfgang Maier1,2, H. H. Schild3, Wolfgang Block3, Michael Wagner1, Frank Träber3
1Department of Psychiatry and Psychotherapy, University of Bonn, Germany
2German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany
3Department of Radiology, University of Bonn, Germany
4Department of Psychiatry and Psychotherapy, University of Saarland, Homburg, Germany

Tóm tắt

Từ khóa


Tài liệu tham khảo

Paz, 2008, Glutamatergic dysfunction in schizophrenia: from basic neuroscience to clinical psychopharmacology, Eur Neuropsychopharmacol, 18, 773, 10.1016/j.euroneuro.2008.06.005

Patil, 2007, Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial, Nat Med, 13, 1102, 10.1038/nm1632

Wroblewska, 1997, N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells, J Neurochem, 69, 174, 10.1046/j.1471-4159.1997.69010174.x

Cartmell, 1998, Characterization of [3H]-(2S,2'R,3'R)-2-(2',3'-dicarboxy-cyclopropyl)glycine ([3H]-DCG IV) binding to metabotropic mGlu2 receptor-transfected cell membranes, Br J Pharmacol, 123, 497, 10.1038/sj.bjp.0701647

Olszewski, 2004, NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR, J Neurochem, 89, 876, 10.1111/j.1471-4159.2004.02358.x

Olszewski, 2008, Phencyclidine and dizocilpine induced behaviors reduced by N-acetylaspartylglutamate peptidase inhibition via metabotropic glutamate receptors, Biol Psychiatry, 63, 86, 10.1016/j.biopsych.2007.04.016

Zhou, 2005, NAAG peptidase inhibitors and their potential for diagnosis and therapy, Nat Rev Drug Discov, 4, 1015, 10.1038/nrd1903

Tsai, 1995, Abnormal excitatory neurotransmitter metabolism in schizophrenic brains, Arch Gen Psychiatry, 52, 829, 10.1001/archpsyc.1995.03950220039008

Nudmamud, 2003, N-acetylaspartate and N-Acetylaspartylglutamate deficits in superior temporal cortex in schizophrenia and bipolar disorder: a postmortem study, Biol Psychiatry, 53, 1138, 10.1016/S0006-3223(02)01742-0

Govindaraju, 2000, Proton NMR chemical shifts and coupling constants for brain metabolites, NMR Biomed, 13, 129, 10.1002/1099-1492(200005)13:3<129::AID-NBM619>3.0.CO;2-V

Bustillo, 2010, (1)H-MRS at 4 tesla in minimally treated early schizophrenia, Mol Psychiatry, 15, 629, 10.1038/mp.2009.121

Jessen, 2006, Proton magnetic resonance spectroscopy in subjects at risk for schizophrenia, Schizophr Res, 87, 81, 10.1016/j.schres.2006.06.011

Steen, 2005, Measurement of brain metabolites by 1H magnetic resonance spectroscopy in patients with schizophrenia: a systematic review and meta-analysis, Neuropsychopharmacology, 30, 1949, 10.1038/sj.npp.1300850

Pan, 2005, Interdependence of N-acetyl aspartate and high-energy phosphates in healthy human brain, Ann Neurol, 57, 92, 10.1002/ana.20317

Moffett, 2007, N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology, Prog Neurobiol, 81, 89, 10.1016/j.pneurobio.2006.12.003

Pouwels, 1997, Differential distribution of NAA and NAAG in human brain as determined by quantitative localized proton MRS, NMR Biomed, 10, 73, 10.1002/(SICI)1099-1492(199704)10:2<73::AID-NBM448>3.0.CO;2-4

Edden, 2007, In vivo differentiation of N-acetyl aspartyl glutamate from N-acetyl aspartate at 3 Tesla, Magn Reson Med, 57, 977, 10.1002/mrm.21234

Kay, 1987, The positive and negative syndrome scale (PANSS) for schizophrenia, Schizophr Bull, 13, 261, 10.1093/schbul/13.2.261

Helmstaedter, 2001, Verbaler Lern- und Merkfähigkeitstest (VLMT)

Tewes, 1991, Hamburg-Wechsler-Intelligenztest für Erwachsene, Revision 1991 (HAWIE-R)

Härting, 2000, Die Wechsler Memory Scale-Revised (WMS-R). Deutsche Version

Gold, 1997, Auditory working memory and Wisconsin Card Sorting Test performance in schizophrenia, Arch Gen Psychiatry, 54, 159, 10.1001/archpsyc.1997.01830140071013

Reitan, 1979, Trail Making Test (TMT)

Naressi, 2001, Java-based graphical user interface for the MRUI quantitation package, MAGMA, 12, 141, 10.1007/BF02668096

Ratiney, 2005, Time-domain semi-parametric estimation based on a metabolite basis set, NMR Biomed, 18, 1, 10.1002/nbm.895

Träber, 2004, 1H metabolite relaxation times at 3.0 tesla: measurements of T1 and T2 values in normal brain and determination of regional differences in transverse relaxation, J Magn Reson Imaging, 19, 537, 10.1002/jmri.20053

Vanhamme, 1997, Improved method for accurate and efficient quantification of MRS data with use of prior knowledge, J Magn Reson, 129, 35, 10.1006/jmre.1997.1244

Ghose, 2009, Differential expression of metabotropic glutamate receptors 2 and 3 in schizophrenia: a mechanism for antipsychotic drug action?, Am J Psychiatry, 166, 812, 10.1176/appi.ajp.2009.08091445

Guilarte, 2008, Dysregulation of glutamate carboxypeptidase II in psychiatric disease, Schizophr Res, 99, 324, 10.1016/j.schres.2007.11.013

Tsai, 2005, Central N-acetyl aspartylglutamate deficit: a possible pathogenesis of schizophrenia, Med Sci Monit, 11, HY39

Arun, 2008, Antipsychotic drugs increase N-acetylaspartate and N-acetylaspartylglutamate in SH-SY5Y human neuroblastoma cells, J Neurochem, 106, 1669, 10.1111/j.1471-4159.2008.05524.x

Fricker, 2009, Effects of N-acetylaspartylglutamate (NAAG) at group II mGluRs and NMDAR, Neuropharmacology, 56, 1060, 10.1016/j.neuropharm.2009.03.002

Wang, 2005, Selective impairment of attentional networks of orienting and executive control in schizophrenia, Schizophr Res, 78, 235, 10.1016/j.schres.2005.01.019

Camchong, 2008, Common neural circuitry supporting volitional saccades and its disruption in schizophrenia patients and relatives, Biol Psychiatry, 64, 1042, 10.1016/j.biopsych.2008.06.015

Tayoshi, 2009, Metabolite changes and gender differences in schizophrenia using 3-Tesla proton magnetic resonance spectroscopy (1H-MRS), Schizophr Res, 108, 69, 10.1016/j.schres.2008.11.014

Lutkenhoff, 2010, Proton MRS in twin pairs discordant for schizophrenia, Mol Psychiatry, 15, 308, 10.1038/mp.2008.87

Théberge, 2003, Glutamate and glutamine in the anterior cingulate and thalamus of medicated patients with chronic schizophrenia and healthy comparison subjects measured with 4.0-T proton MRS, Am J Psychiatry, 160, 2231, 10.1176/appi.ajp.160.12.2231

Olbrich, 2008, Frontolimbic glutamate alterations in first episode schizophrenia: evidence from a magnetic resonance spectroscopy study, World J Biol Psychiatry, 9, 59, 10.1080/15622970701227811

Provencher, 1993, Estimation of metabolite concentrations from localized in vivo proton NMR spectra, Magn Reson Med, 30, 672, 10.1002/mrm.1910300604