N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: Indazoles as phenol isosteres with improved pharmacokinetics

Molina, 1992, Nature, 357, 161, 10.1038/357161a0 Levin, 1993, EMBO J., 12, 1671, 10.1002/j.1460-2075.1993.tb05812.x Lovatt, 2006, Mol. Cell Biol., 26, 8655, 10.1128/MCB.00168-06 van Oers, 1996, J. Exp. Med., 183, 1053, 10.1084/jem.183.3.1053 Weiss, 1994, Cell, 76, 263, 10.1016/0092-8674(94)90334-4 Weil, 1996, Curr. Topics Microbiol. Immunol., 205, 63 Bolen, 1997, Ann. Rev. Immunol., 15, 371, 10.1146/annurev.immunol.15.1.371 Kamens, 2001, Curr. Opin. Invest. Drugs, 2, 1213 Golas, 2003, Cancer Res., 63, 375 Hennequin, 1999, J. Med. Chem., 42, 5369, 10.1021/jm990345w See numerous patents, including Davis, P.; Moffat, D.; Davis, J.; Hutchings, M. WO1997019065, 1997. Dev, 2004, Br. J. Cancer, 91, 1391, 10.1038/sj.bjc.6602109 Zhu, 1999, Structure, 7, 651, 10.1016/S0969-2126(99)80086-0 Jones, 1997, J. Mol. Biol., 267, 727, 10.1006/jmbi.1996.0897 Beattie, 2003, Bioorg. Med. Chem. Lett., 13, 2955, 10.1016/S0960-894X(03)00202-6 Manuscript in preparation, Bioorg. Med. Chem. Lett. Sabat, 2006, Bioorg. Med. Chem. Lett., 16, 5973, 10.1016/j.bmcl.2006.08.132 Hennequin, 2006, J. Med. Chem., 49, 6465, 10.1021/jm060434q Jeong, 2005, Curr. Drug Metab., 6, 455, 10.2174/138920005774330657