Myoclonies atypiques sévères répondant rapidement à l’immunothérapie : l’encéphalite limbique à anticorps anti-LGI1

Chernova, 1998, A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors, Oncogene, 17, 2873, 10.1038/sj.onc.1202481 Fukata, 2006, Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission, Science, 313, 1792, 10.1126/science.1129947 Fukata, 2010, Disruption of LGI1-linked synaptic complex causes abnormal synaptic transmission and epilepsy, Proc Natl Acad Sci U S A, 107, 3799, 10.1073/pnas.0914537107 Irani, 2010, Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia, Brain, 133, 2734, 10.1093/brain/awq213 Irani, 2011, Faciobrachial dystonic seizures precede Lgi1 antibody limbic encephalitis, Ann Neurol, 69, 892, 10.1002/ana.22307 Lai, 2010, Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series, Lancet Neurol, 9, 776, 10.1016/S1474-4422(10)70137-X Lancaster, 2011, Encephalitis and antibodies to synaptic and neuronal cell surface proteins, Neurology, 77, 179, 10.1212/WNL.0b013e318224afde Vincent, 2004, Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis, Brain, 127, 701, 10.1093/brain/awh077