Myocardial localization of coronavirus in COVID‐19 cardiogenic shock

European Journal of Heart Failure - Tập 22 Số 5 - Trang 911-915 - 2020
Guido Tavazzi1,2, Carlo Pellegrini3,1, M. Maurelli4, Mirko Belliato2, Fabio Sciutti2, Andrea Bottazzi2, Paola Alessandra Sepe5, Tullia Resasco5, Rita Camporotondo6, Raffaele Bruno1,7, Fausto Baldanti1,8, Stefania Paolucci8, Stefano Pelenghi3, Giorgio Antonio Iotti1,2, Francesco Mojoli1,2, Eloisa Arbustini9
1Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy
2ICU1 Department of Intensive Medicine, IRCCS Policlinico San Matteo Foundation, Pavia, Italy
3Cardiac Surgery, Department of Intensive Medicine, IRCCS Policlinico San Matteo Foundation, Pavia, Italy
4ICU2, Department of Intensive Medicine, IRCCS Policlinico San Matteo Foundation, Pavia, Italy
5Cardiology Unit, Ospedale Maggiore, ASST, Lodi, Italy
6Coronary Care Unit and Laboratory of Clinical and Experimental Cardiology, Department of Medical Sciences and Infectious Diseases, IRCCS Policlinico San Matteo Foundation, Pavia, Italy
7Infectious Diseases I, Department of Medical Sciences and Infectious Diseases, IRCCS Policlinico San Matteo Foundation, Pavia, Italy
8Molecular Virology Unit, Department of Diagnostic Medicine, IRCCS Policlinico San Matteo Foundation, Pavia, Italy
9Transplant Research Area and Centre for Inherited Cardiovascular Diseases, Department of Medical Sciences and Infectious Diseases, IRCCS Policlinico San Matteo Foundation, Pavia, Italy

Tóm tắt

AbstractWe describe the first case of acute cardiac injury directly linked to myocardial localization of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in a 69‐year‐old patient with flu‐like symptoms rapidly degenerating into respiratory distress, hypotension, and cardiogenic shock. The patient was successfully treated with venous‐arterial extracorporeal membrane oxygenation (ECMO) and mechanical ventilation. Cardiac function fully recovered in 5 days and ECMO was removed. Endomyocardial biopsy demonstrated low‐grade myocardial inflammation and viral particles in the myocardium suggesting either a viraemic phase or, alternatively, infected macrophage migration from the lung.

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Tài liệu tham khảo

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Thông tin xuất bản

European Journal of Heart Failure

Tập 22 Số 5

911-915

Thông tin tác giả