Myeloma light chain cast nephropathy, a review

Springer Science and Business Media LLC - Tập 32 - Trang 189-198 - 2018
Insara Jaffer Sathick1, Maria Eleni Drosou2, Nelson Leung2,3
1Renal Service, Division of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA
2Division of Nephrology and Hypertension, Mayo Clinic, Rochester, USA
3Division of Hematology, Mayo Clinic, Rochester, USA

Tóm tắt

Multiple Myeloma is a plasma cell proliferative disorder that commonly involves the kidney. Renal impairment is a serious complication during the course of the disease that is associated with increased morbidity and mortality. Light chain cast nephropathy is the predominant pattern of renal injury in Multiple Myeloma. This review article focuses on the pathophysiology and diagnostic approach of myeloma cast nephropathy. The management of precipitating factors as well as anti-plasma cell treatment modalities in the context of renal impairment are also discussed.

Tài liệu tham khảo

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