Myelinopathia centralis diffusa (vanishing white matter disease) in a four-year-old boy

Brockmann, 1995, Myelinopathia Centralis diffusa and cystic leukoencephalopathy: Clinical, MRI and MRS characteristics, Neuropediatrics, 26, 342 Bruck, 2001, Myelinopathia centralis diffusa (vanishing white matter disease): evidence of apoptotic oligodendrocyte degeneration in early lesion development, Ann Neurol, 50, 532, 10.1002/ana.1227 Frahm, 1997, Localized proton magnetic resonance spectroscopy of brain disorders in childhood, 329 Frahm, 1990, Improvements in localized proton NMR spectroscopy of human brain. Water suppression, short echo times, and 1 ml resolution, Journal of Magnetic Resonance, 90, 464 Hanefeld, 1993, Diffuse white matter disease in three children: an encephalopathy with unique features on magnetic resonance imaging and proton magnetic resonance spectroscopy, Neuropediatrics, 24, 244, 10.1055/s-2008-1071551 Leegwater, 1999, The gene for leukoencephalopathy with vanishing white matter is located on chromosome 3q27, Am J Hum Genet, 65, 728, 10.1086/302548 Leegwater, 2001, Subunits of the translation initiation factor e IF2B are mutant in leukoencephalopathy with vanishing white matter, Nature Genetics, 29, 383, 10.1038/ng764 Pouwels, 1999, Regional age dependence of human brain metabolites from infancy to adulthood as detected by quantitative localized proton MRS, Pediatric Research, 46, 474, 10.1203/00006450-199910000-00019 Rodriguez, 1999, Increased density of oligodendrocytes in childhood ataxia with diffuse central hypomyelination (CACH) syndrome: neuropathological and biochemical studies of two cases, Acta Neuropath, 97, 469, 10.1007/s004010051016 Van der Knaap, 1997, A new leukoencephalopathy with vanishing white matter, Neurology, 48, 845, 10.1212/WNL.48.4.845