Myelin movements in mature mammalian peripheral nerve fibers

Journal of Morphology - Tập 143 Số 2 - Trang 167-185 - 1974
Gershon Gitlin1,2, Marcus Singer1
1Department of Anatomy, Case Western Reserve University, Cleveland, Ohio 44106
2While on sabbatical leave from the Department of Anatomy, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.

Tóm tắt

AbstractMature mouse and cat peripheral nerve fibers have been examined in vitro by time‐lapse photography. Some Schmidt‐Lanterman clefts which were open at the start closed later; other were seen to open and then to close, some of them more than once. The implications of these movements are considered, especially in regard to the question of the passage of materials from the endoneurial connective tissue spaces to the axon.Myelin movements other than those occurring at the Schmidt‐Lanterman clefts consisted primarily of the development and frequent regression of indentations of the myelin sheath. A single evagination was seen to develop and then to recede. These myelin movements suggest that previously described invaginations and evaginations of the myelin sheath, including flaps of “redundant myelin”, are not static but rather that they are in a state of movement, forming and regressing at intervals.The possible functional significance of the development and regression of myelin sheath indentations in relationship to axoplasmic flow is discussed.

Từ khóa


Tài liệu tham khảo

1967, Axoplasmic Transport. A Report of an NRP‐Work Session, Neurosci. Res. Progr. Bull., 5, 307

Berthold C. H., 1968, A study of the fixation of large mature feline myelinated ventral lumbar spinal nerve roots, Acta Soc. Med., Upsal., 73, 1

Berthold C. H., 1968, Ultrastructure of the node‐paranode region of mature feline ventral spinal root fibers, Acta Soc. Med. Upsal., 73, 37

Berthold C. H., 1968, Postnatal development of feline paranodal myelin sheath segments. I. Light microscopy, Acta Soc. Med. Upsal., 73, 113

Berthold C. H., 1968, Postnatal development of feline paranodal myelin sheath segments. II. Electronmicroscopy, Acta Soc. Med. Upsal., 73, 127

10.1083/jcb.4.5.499

y Cajal S. R., 1928, Degeneration and Regeneration of the Nervous System, 1959

10.1111/j.1471-4159.1969.tb05981.x

10.1016/0014-4886(69)90138-1

10.1002/cne.900470304

10.1038/1931004a0

10.1016/S0022-5320(63)80023-4

10.1007/BF00569272

10.1113/jphysiol.1966.sp007877

Fraher J. P., 1972, A quantitative study of anterior root fibres during early myelination, J. Anat., 112, 99

10.1002/cne.901300304

10.1002/ar.1091650110

Hall S. M., 1970, Studies on the ‘incisures’ of Schmidt and Lanterman, J. Cell Sci., 6, 767, 10.1242/jcs.6.3.767

10.1002/jez.1400090405

10.1083/jcb.23.2.277

10.1007/BF01106147

Hild W., 1959, Biology of Myelin. Progress in Neurobiology, 188

10.1016/S0022-5320(69)90012-4

Jacobson M., 1970, Developmental Neurobiology

10.1002/aja.1001360102

Landon D. N., 1971, The local chemical environment of nodes of Ranvier; a study of cation binding, J. Anat., 108, 419

10.1016/S0074-7742(08)60173-7

10.1002/cne.901200107

Lewis P. R., 1971, The use of cholinesterase techniques to study topographical localizations in the hypoglossal nucleus of the rat, J. Anat., 110, 203

Lubinska L., 1964, Progress in Brain Research, Mechanisms of Neural Regeneration, 1

10.1083/jcb.2.6.777

10.1016/B978-0-08-010465-2.50009-6

Murray M. R.(1968): In discussion on paper by M. Singer: Penetration of labelled amino acids into the peripheral nerve fiber from surrounding body fluids. In:Ciba Foundation Symposium Growth of the Nervous System. G. E. W. Wolstenholme and M. O'Connor eds. pp.200–218.

Murray M. R., 1968, Passive movements of Schmidt‐Lanterman clefts during continuous observations in vitro, J. Cell Biol., 39, 149A

Ochoa J., 1971, The sural nerve of the human foetus; electron microscope observations and counts of axons, J. Anat., 108, 231

10.1016/0014-4886(65)90100-7

Ochs S., 1966, Macromolecules and Behavior, 20

Ottoson D., 1952, Structural properties of the myelinated fibre as revealed by microinjection, Acta Physiol. Scand., 29, 61

10.1113/expphysiol.1959.sp001366

10.1111/j.1749-6632.1965.tb20190.x

10.1002/ar.1091440404

Pick J., 1970, The Autonomic Nervous System, 125

10.1126/science.130.3391.1759-a

Pomerat C. M., 1967, The Neuron, 118

Quilliam T. A., 1956, Some characteristics of myelinated fibre populations, J. Anat., 90, 172

10.1083/jcb.28.1.73

Singer M.(1968): Penetration of labelled amino acids into the peripheral nerve fiber from surrounding body fluids. In:Ciba Foundation Symposium Growth of the Nervous System. G. E. M. Wolstenholme and M. O'Connor eds. pp.200–218.

10.1038/2211148a0

10.1002/jmor.1051240306

10.1002/ar.1091730401

10.1002/jmor.1051200305

10.1002/aja.1001330105

Sotnikov O. S., 1965, Structure of Schmidt‐Lanterman incisures, Arkh. Anat. Gistol. Embriol. (Moscow), 43, 31

Sotnikov O. S., 1965, Structure of Schmidt‐Lanterman incisures, Arkh. Anat. Gistol. Embriol. (Moscow), 25, 204

10.1002/aja.1000520102

Steer J. M., 1971, Some observations on the fine structure of rat dorsal spinal nerve roots, J. Anat., 109, 467

10.1083/jcb.4.5.551

10.1083/jcb.48.2.348

10.1097/00005072-196001000-00005

Weiss P., 1963, The Effect of Use and Disuse on Neuromuscular Functions, 171

Weiss P., 1967, Neuronal dynamics, an essay, Neurosci. Res. Progr. Bull., 5, 371

10.1002/jez.1401070302

10.1126/science.136.3513.330

Williams P. L., 1970, In vivo observations on mature myelinated nerve fibres of the mouse, J. Anat., 107, 31

Williams P. L., 1971, Prolonged in vivo observations of normal peripheral nerve fibres and their acute reactions to crush and deliberate trauma, J. Anat., 108, 397

10.1038/198670a0

Thông tin
Thông tin xuất bản

Journal of Morphology

Tập 143 Số 2

167-185

Thông tin tác giả