Mutations in the P. falciparum Digestive Vacuole Transmembrane Protein PfCRT and Evidence for Their Role in Chloroquine Resistance

Bitonti, 1988, Reversal of chloroquine resistance in malaria parasite Plasmodium falciparum by desipramine, Science, 242, 1301, 10.1126/science.3057629

Bray, 1998, Access to hematin, Mol. Pharmacol, 54, 170, 10.1124/mol.54.1.170

Cowman, 1991, A P-glycoprotein homologue of Plasmodium falciparum is localized on the digestive vacuole, J. Cell Biol, 113, 1033, 10.1083/jcb.113.5.1033

Crabb, 1997, Stable transgene expression in Plasmodium falciparum, Mol. Biochem. Parasitol, 90, 131, 10.1016/S0166-6851(97)00143-6

De, 1996, Aminoquinolines that circumvent resistance in Plasmodium falciparum in vitro, Am. J. Trop. Med. Hyg, 55, 579, 10.4269/ajtmh.1996.55.579

Dorn, 1998, An assessment of drug-haematin binding as a mechanism for inhibition of haematin polymerisation by quinoline antimalarials, Biochem. Pharmacol, 55, 727, 10.1016/S0006-2952(97)00510-8

Dzekunov, 2000, Digestive vacuolar pH of intact intraerythrocytic P. falciparum either sensitive or resistant to chloroquine, Mol. Biochem. Parasitol, 110, 107, 10.1016/S0166-6851(00)00261-9

Fidock, 1997, Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil, Proc. Natl. Acad. Sci. USA, 94, 10931, 10.1073/pnas.94.20.10931

Fidock, 1998, Cycloguanil and its parent compound proguanil demonstrate distinct activities against Plasmodium falciparum malaria parasites transformed with human dihydrofolate reductase, Mol. Pharmacol, 54, 1140, 10.1124/mol.54.6.1140

Fidock, 2000, Allelic modifications of the cg2 and cg1 genes do not alter the chloroquine response of drug-resistant Plasmodium falciparum, Mol. Biochem. Parasitol, 110, 1, 10.1016/S0166-6851(00)00249-8

Fitch, 1970, Plasmodium falciparum in owl monkeys, Science, 169, 289, 10.1126/science.169.3942.289

Ginsburg, 1998, Inhibition of glutathione-dependent degradation of heme by chloroquine and amodiaquine as a possible basis for their antimalarial mode of action, Biochem. Pharmacol, 56, 1305, 10.1016/S0006-2952(98)00184-1

Goldberg, 1990, Hemoglobin degradation in the malaria parasite Plasmodium falciparum, Proc. Natl. Acad. Sci. USA, 87, 2931, 10.1073/pnas.87.8.2931

Hoffman, 1996, Are altered pHi and membrane potential in hu MDR 1 transfectants sufficient to cause MDR protein-mediated multidrug resistance?, J. Gen. Physiol, 108, 295, 10.1085/jgp.108.4.295

Krogstad, 1985, Antimalarials increase vesicle pH in Plasmodium falciparum, J. Cell Biol, 101, 2302, 10.1083/jcb.101.6.2302

Levin, 2000, Compensatory mutations, antibiotic resistance and the population genetics of adaptive evolution in bacteria, Genetics, 154, 985, 10.1093/genetics/154.3.985

Luz, 1994, Transfection of mu MDR 1 inhibits Na(+)-independent Cl-/-HCO3 exchange in Chinese hamster ovary cells, Biochemistry, 33, 7239, 10.1021/bi00189a028

Marsh, 1998, Malaria disaster in Africa, Lancet, 352, 924, 10.1016/S0140-6736(05)61510-3

Martin, 1987, Reversal of chloroquine resistance in Plasmodium falciparum by verapamil, Science, 235, 899, 10.1126/science.3544220

Martiney, 1995, Verapamil reversal of chloroquine resistance in the malaria parasite Plasmodium falciparum is specific for resistant parasites and independent of the weak base effect, J. Biol. Chem, 270, 22393, 10.1074/jbc.270.38.22393

Martiney, J.A., Ferrer, A.S., Cerami, A., Dzekunov, S., and Roepe, P.D. (1999). Chloroquine uptake, altered partitioning and the basis of drug resistance: evidence for a role of chloride-dependent ionic regulation. In Novartis Foundation Symposium 226: Transport and Trafficking in the Malaria-Infected Erythrocyte. (Chichester: John Wiley and Sons), pp. 265–274.

Payne, 1987, Spread of chloroquine resistance in Plasmodium falciparum, Parasitol. Today, 3, 241, 10.1016/0169-4758(87)90147-5

Peters, 1989, Antihistaminic drugs that reverse chloroquine resistance in Plasmodium falciparum, Lancet, 2, 334, 10.1016/S0140-6736(89)90522-9

Piper, 1999, Immunocapture diagnostic assays for malaria using Plasmodium lactate dehydrogenase (pLDH), Am. J. Trop. Med. Hyg, 60, 109, 10.4269/ajtmh.1999.60.109

Reed, 2000, Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum, Nature, 403, 906, 10.1038/35002615

Ridley, 1996, 4-aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum, Antimicrob. Agents Chemother, 40, 1846, 10.1128/AAC.40.8.1846

Saliba, 1998, Role for the Plasmodium falciparum digestive vacuole in chloroquine resistance, Biochem. Pharmacol, 56, 313, 10.1016/S0006-2952(98)00140-3

Srivastava, 1999, Pharmacogenomics of the cystic fibrosis transmembrane conductance regulator (CFTR) and the cystic fibrosis drug CPX using genome microarray analysis, Mol. Med, 5, 753, 10.1007/BF03402099

Su, 1997, Complex polymorphisms in a ∼330 kDa protein are linked to chloroquine-resistant P. falciparum in Southeast Asia and Africa, Cell, 91, 593, 10.1016/S0092-8674(00)80447-X

Su, 1998, Plasmodium falciparum, Exp. Parasitol, 89, 262, 10.1006/expr.1998.4299

Su, 1999, A genetic map and recombination parameters of the human malaria parasite Plasmodium falciparum, Science, 286, 1351, 10.1126/science.286.5443.1351

Tanaka, 1990, Mutant dihydrofolate reductase-thymidylate synthase genes in pyrimethamine-resistant Plasmodium falciparum with polymorphic chromosome duplications, Mol. Biochem. Parasitol, 42, 83, 10.1016/0166-6851(90)90115-3

Thaithong, 1992, Pyrimethamine resistant mutations in Plasmodium falciparum, Mol. Biochem. Parasitol, 52, 149, 10.1016/0166-6851(92)90047-N

Trape, 1998, Impact of chloroquine resistance on malaria mortality, C. R. Acad. Sci. III, 321, 689, 10.1016/S0764-4469(98)80009-7

Ursos, 2000, The effects of chloroquine and verapamil on digestive vacuolar pH of P. falciparum either sensitive of resistant to chloroquine, Mol. Biochem. Parasitol, 110, 125, 10.1016/S0166-6851(00)00262-0

Wellems, 1990, Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum cross, Nature, 345, 253, 10.1038/345253a0

Wellems, 1991, Genetic mapping of the chloroquine-resistance locus on Plasmodium falciparum chromosome 7, Proc. Natl. Acad. Sci. USA, 88, 3382, 10.1073/pnas.88.8.3382

Wilson, 1999, Exploring drug-induced alterations in gene expression in Mycobacterium tuberculosis by microarray hybridization, Proc. Natl. Acad. Sci. USA, 96, 12833, 10.1073/pnas.96.22.12833

Wu, 1995, Transfection of Plasmodium falciparum within human red blood cells, Proc. Natl. Acad. Sci. USA, 92, 973, 10.1073/pnas.92.4.973

Wu, 1996, Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine, Proc. Natl. Acad. Sci. USA, 93, 1130, 10.1073/pnas.93.3.1130

Wunsch, 1998, Differential stimulation of the Na+/H+ exchanger determines chloroquine uptake in Plasmodium falciparum, J. Cell Biol, 140, 335, 10.1083/jcb.140.2.335

Yayon, 1984, Identification of the acidic compartment of Plasmodium falciparum-infected human erythrocytes as the target of the antimalarial drug chloroquine, EMBO J, 3, 2695, 10.1002/j.1460-2075.1984.tb02195.x