Mutation of the BRCA1 SQ-cluster results in aberrant mitosis, reduced homologous recombination, and a compensatory increase in non-homologous end joining

Oncotarget - Tập 6 Số 29 - Trang 27674-27687 - 2015
Jason M. Beckta1,2, Seth M. Dever1,2, Nisha Gnawali2, Ashraf Khalil2, Amrita Sule1,2, Sarah E. Golding2, Elizabeth Rosenberg2, Aarthi Narayanan3, Kylene Kehn‐Hall3, Bo Xu4, Lawrence F. Povirk5, Kristoffer Valerie1,2,6
1Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, VA 23298, USA
2Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA 23298, USA.
3National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA 20110, USA
4Cancer Research Department, Southern Research Institute, Birmingham, AL 35205, USA.
5Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, 23298 USA
6Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA

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