Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer’s disease: analysis of Osaka mutation-knockin mice

Acta Neuropathologica Communications - Tập 5 Số 1 - 2017
Tomohiro Umeda1, Tetsuya Kimura2, Kayo Yoshida3, Keizo Takao4, Yuki Fujita1, Shogo Matsuyama5, Ayumi Sakai1, M. Yamashita1, Yūki Yamashita1, Kiyouhisa Ohnishi1, Mamiko Suzuki2, Hiroshi Takuma1, Tsuyoshi Miyakawa4, Akihiko Takashima2, Takashi Morita3, Hiroshi Mori6, Takami Tomiyama7
1Department of Translational Neuroscience, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, 545-8585, Japan
2Department of Aging Neurobiology, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu, Japan
3Department of Molecular Genetics, Osaka City University Graduate School of Medicine, Osaka, Japan
4Section of Behavior Patterns, Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki, Japan
5Biosignal Research Center, Kobe University, Kobe, Japan
6Department of Clinical Neuroscience, Osaka City University Medical School, Osaka, Japan
7Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi, Japan

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