Mutant N-ras preferentially drives human CD34+ hematopoietic progenitor cells into myeloid differentiation and proliferation both in vitro and in the NOD/SCID mouse

Experimental Hematology - Tập 32 - Trang 852-860 - 2004
Sylvie W. Shen1, Alla Dolnikov1, Toby Passioura1,2, Michelle Millington2, Simon Wotherspoon3, Alison Rice1, Karen L. MacKenzie1, Geoff Symonds1,2,4
1Children's Cancer Institute Australia for Medical Research, Randwick, NSW, Australia
2School of Medical Science, University of New South Wales, Sydney, NSW, Australia
3School of Biotechnology, University of New South Wales, NSW, Australia
4Johnson & Johnson Laboratories, Strawberry Hills, NSW, Australia

Tài liệu tham khảo

Shimizu, 1983, Three human transforming genes are related to the viral ras oncogenes, Proc Natl Acad Sci U S A, 80, 2112, 10.1073/pnas.80.8.2112 Barbacid, 1987, ras genes, Annu Rev Biochem, 56, 779, 10.1146/annurev.bi.56.070187.004023 Boguski, 1993, Proteins regulating Ras and its relatives, Nature, 366, 643, 10.1038/366643a0 Valencia, 1991, The ras protein family: evolutionary tree and role of conserved amino acids, Biochemistry, 30, 4637, 10.1021/bi00233a001 Byrne, 1998, The molecular pathophysiology of myeloid leukaemias: Ras revisited, Br J Haematol, 100, 256, 10.1046/j.1365-2141.1998.00554.x Bos, 1989, Ras oncogenes in human cancer: a review, Cancer Res, 49, 4682 Reuter, 2000, Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies?, Blood, 96, 1655, 10.1182/blood.V96.5.1655 Sawyers, 1994, Chronic myelomonocytic leukemia: Tela-kinase what Ets all about, Cell, 77, 171, 10.1016/0092-8674(94)90307-7 Beaupre, 1999, RAS and leukemia: from basic mechanisms to gene-directed therapy, J Clin Oncol, 17, 1071, 10.1200/JCO.1999.17.3.1071 Serrano, 1997, Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a, Cell, 88, 593, 10.1016/S0092-8674(00)81902-9 Newbold, 1983, Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene, Nature, 304, 648, 10.1038/304648a0 Delgado, 2000, H-, K- and N-Ras inhibit myeloid leukemia cell proliferation by a p21WAF1-dependent mechanism, Oncogene, 19, 783, 10.1038/sj.onc.1203384 Maher, 1996, Mutant ras promotes haemopoietic cell proliferation or differentiation in a cell-specific manner, Leukemia, 10, 83 Darley, 1999, Mutant RAS inhibits neutrophil but not macrophage differentiation and allows continued growth of neutrophil precursors, Exp Hematol, 27, 1599, 10.1016/S0301-472X(99)00100-9 MacKenzie, 1999, Mutant N-ras induces myeloproliferative disorders and apoptosis in bone marrow repopulated mice, Blood, 93, 2043, 10.1182/blood.V93.6.2043.406k17_2043_2056 Darley, 1997, Mutant N-RAS induces erythroid lineage dysplasia in human CD34+ cells, J Exp Med, 185, 1337, 10.1084/jem.185.7.1337 Darley, 2002, Protein kinase C mediates mutant N-Ras-induced developmental abnormalities in normal human erythroid cells, Blood, 100, 4185, 10.1182/blood-2002-05-1358 Bender, 1987, Evidence that the packaging signal of Moloney murine leukemia virus extends into the gag region, J Virol, 61, 1639, 10.1128/jvi.61.5.1639-1646.1987 Scherr, 1997, Specific hammerhead ribozyme-mediated cleavage of mutant N-ras mRNA in vitro and ex vivo, The Journal of Biological Chemistry, 272, 14304, 10.1074/jbc.272.22.14304 Dolnikov, 1996, Apoptosis in v-myc transformation of myelomonocytic cells and its modulation by CSF-1, Oncogene, 12, 1189 Dolnikov, 2003, A sensitive dual fluorescence reporter system enables positive selection of Ras suppressors by suppression of Ras-induced apoptosis, Cancer Gene Ther, 10, 745, 10.1038/sj.cgt.7700603 Lu, 1996, Retrovirus-mediated gene expression in hematopoietic cells correlates inversely with growth factor stimulation, Hum Gene Ther, 7, 2263, 10.1089/hum.1996.7.18-2263 Lund-Johansen, 1993, Differential surface expression of cell adhesion molecules during granulocyte maturation, J Leukoc Biol, 54, 47, 10.1002/jlb.54.1.47 Tonnelle, 2001, Forced expression of the Ikaros 6 isoform in human placental blood CD34+ cells impairs their ability to differentiate toward the B-lymphoid lineage, Blood, 98, 2673, 10.1182/blood.V98.9.2673 Iritani, 1997, Control of B cell development by Ras-mediated activation of Raf, EMBO J, 16, 7019, 10.1093/emboj/16.23.7019 van der Loo, 1998, VLA-5 expressed by mouse and human long-term repopulating hematopoietic cells and mediates adhesion to extracellular matrix protein fibronectin, J Clin Invest, 102, 1051, 10.1172/JCI3687 Verfaillie, 1998, Adhesion receptors as regulators of the hematopoietic process, Blood, 92, 2609, 10.1182/blood.V92.8.2609 Vermeulen, 1998, Role of adhesion molecules in the homing and mobilization of murine hematopoietic stem and progenitor cells, Blood, 92, 894, 10.1182/blood.V92.3.894 Quesenberry, 1998, Stem cell homing: rolling, crawling, and nesting, Proc Natl Acad Sci U S A, 95, 15155, 10.1073/pnas.95.26.15155 Peled, 2000, The chemokine SDF-1 activates the integrins LFA-1, VLA-4, and VLA-5 on immature human CD34+ cells: role in transendothelial/stromal migration and engraftment of NOD/SCID mice, Blood, 95, 3289, 10.1182/blood.V95.11.3289 Hirsch, 1996, Impaired migration but not differentiation of hematopoietic stem cells in the absence of b1 integrins, Nature, 380, 171, 10.1038/380171a0