Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

Wall, P. D. & Melzack, R. The Textbook of Pain (W. B. Saunders, London, 1999)

Jancso, N., Jancso-Gabor, A. & Szolcsanyi, J. Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin. Br. J. Pharmacol. 31, 138–151 (1967)

Jaquemar, D., Schenker, T. & Trueb, B. An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts. J. Biol. Chem. 274, 7325–7333 (1999)

Story, G. M. et al. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112, 819–829 (2003)

Zygmunt, P. M. et al. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 400, 452–457 (1999)

Bisogno, T. et al. Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br. J. Pharmacol. 134, 845–852 (2001)

Di Marzo, V., Bisogno, T. & De Petrocellis, L. Anandamide: some like it hot. Trends Pharmacol. Sci. 22, 346–349 (2001)

Ross, R. A. Anandamide and vanilloid TRPV1 receptors. Br. J. Pharmacol. 140, 790–801 (2003)

Lembeck, F. & Holzer, P. Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation. Naunyn Schmiedebergs Arch. Pharmacol. 310, 175–183 (1979)

Louis, S. M., Jamieson, A., Russell, N. J. & Dockray, G. J. The role of substance P and calcitonin gene-related peptide in neurogenic plasma extravasation and vasodilatation in the rat. Neuroscience 32, 581–586 (1989)

Szallasi, A. & Blumberg, P. M. Vanilloid (capsaicin) receptors and mechanisms. Pharmacol. Rev. 51, 159–212 (1999)

Caterina, M. J. et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389, 816–824 (1997)

Tominaga, M. et al. The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 21, 531–543 (1998)

Montell, C., Birnbaumer, L. & Flockerzi, V. The TRP channels, a remarkably functional family. Cell 108, 595–598 (2002)

Jordt, S. E., McKemy, D. D. & Julius, D. Lessons from peppers and peppermint: the molecular logic of thermosensation. Curr. Opin. Neurobiol. 13, 487–492 (2003)

Clapham, D. E. TRP channels as cellular sensors. Nature 426, 517–524 (2003)

Reeh, P. W., Kocher, L. & Jung, S. Does neurogenic inflammation alter the sensitivity of unmyelinated nociceptors in the rat? Brain Res. 384, 42–50 (1986)

Caterina, M. J. et al. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288, 306–313 (2000)

Jancso, G., Kiraly, E. & Jancso-Gabor, A. Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones. Nature 270, 741–743 (1977)

Simons, C. T., Carstens, M. I. & Carstens, E. Oral irritation by mustard oil: self-desensitization and cross-desensitization with capsaicin. Chem. Senses 28, 459–465 (2003)

Caterina, M. J. & Julius, D. The vanilloid receptor: a molecular gateway to the pain pathway. Annu. Rev. Neurosci. 24, 487–517 (2001)

Zygmunt, P. M., Andersson, D. A. & Hogestatt, E. D. Δ9-Tetrahydrocannabinol and cannabinol activate capsaicin-sensitive sensory nerves via a CB1 and CB2 cannabinoid receptor-independent mechanism. J. Neurosci. 22, 4720–4727 (2002)

Wilson, R. K., Kwan, T. K., Kwan, C. Y. & Sorger, G. J. Effects of papaya seed extract and benzyl isothiocyanate on vascular contraction. Life Sci. 71, 497–507 (2002)

Patacchini, R., Maggi, C. A. & Meli, A. Capsaicin-like activity of some natural pungent substances on peripheral endings of visceral primary afferents. Naunyn Schmiedebergs Arch. Pharmacol. 342, 72–77 (1990)

McKemy, D. D., Neuhausser, W. M. & Julius, D. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416, 52–58 (2002)

Peier, A. M. et al. A TRP channel that senses cold stimuli and menthol. Cell 108, 705–715 (2002)

Rang, H. P., Bevan, S. & Dray, A. in Textbook of Pain (eds Wall, P. D. & Melzack, R.) 57–78 (Churchill-Livingstone, London, 1994)

Smart, D. et al. The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1). Br. J. Pharmacol. 129, 227–230 (2000)

Jordt, S. E., Tominaga, M. & Julius, D. Acid potentiation of the capsaicin receptor determined by a key extracellular site. Proc. Natl Acad. Sci. USA 97, 8134–8139 (2000)