Muscle-Specific FXR1 Isoforms in Squamous Cell Cancer

Khandjian, 1998, Novel isoforms of the fragile X related protein FXR1P are expressed during myogenesis, Hum. Mol. Genet., 7, 2121, 10.1093/hmg/7.13.2121 Kirkpatrick, 1999, Alternative splicing in the murine and human FXR1 genes, Genomics, 59, 193, 10.1006/geno.1999.5868 Dube, 2000, Muscle specific fragile X related protein 1 isoforms are sequestered in the nucleus of undifferentiated myoblast, BMC Genet., 1, 4, 10.1186/1471-2156-1-4 Bechara, 2007, Fragile X related protein 1 isoforms differentially modulate the affinity of fragile X mental retardation protein for G-quartet RNA structure, Nucleic Acids Res., 35, 299, 10.1093/nar/gkl1021 Davidovic, 2008, Alteration of expression of muscle specific isoforms of the fragile X related protein 1 (FXR1P) in facioscapulohumeral muscular dystrophy patients, J. Med. Genet., 45, 679, 10.1136/jmg.2008.060541 Davidovic, 2013, A novel role for the RNA-binding protein FXR1P in myoblasts cell-cycle progression by modulating p21/Cdkn1a/Cip1/Waf1 mRNA stability, PLoS Genet., 9, 10.1371/journal.pgen.1003367 Gallagher, 2011, Rbfox-regulated alternative splicing is critical for zebrafish cardiac and skeletal muscle functions, Dev. Biol., 359, 251, 10.1016/j.ydbio.2011.08.025 Cardinali, 2016, MicroRNA-222 regulates muscle alternative splicing through Rbm24 during differentiation of skeletal muscle cells, Cell Death Dis., 7, e2086, 10.1038/cddis.2016.10 Majumder, 2016, RNA-binding protein FXR1 regulates p21 and TERC RNA to bypass p53-mediated cellular senescence in OSCC, PLoS Genet., 12 Qian, 2015, The RNA binding protein FXR1 is a new driver in the 3q26-29 amplicon and predicts poor prognosis in human cancers, Proc. Natl. Acad. Sci. U. S. A., 112, 3469, 10.1073/pnas.1421975112 Comtesse, 2007, Frequent overexpression of the genes FXR1, CLAPM1 and EIF4G located on amplicon 3q26-27 in squamous cell carcinoma of the lung, Int. J. Cancer, 120, 2538, 10.1002/ijc.22585 Goldman, 2018, The UCSC Xena Platform for cancer genomics data visualization and interpretation, bioRxiv