Multisystem Inflammatory Syndrome Associated With Coronavirus Disease in Children

Pediatric Infectious Disease Journal - Tập 39 Số 11 - Trang e374-e376 - 2020
Emmerson Carlos Franco de Farias1,2, Jefferson Pedro Piva3, Mary L. F. M. F. de Mello1, Luciana M P P do Nascimento1, Carina C. Costa1, Mayara M. M. Machado1, Thatiane da S. Rodrigues1, Railana D. F. P. Carvalho1, Marília C. B. Alves1, Larisse F. Q. Aires1, Marilia L. M. Cotta4, Ana R. G. Pedreira5, Salma B. Saraty6, Miriam C. Lima6, Maria Cleonice Aguiar Justino1,3
1Department of Pediatrics, Division of Pediatric Intensive Care, Fundação Santa Casa de Misericórdia do Pará’s Hospital—FSCMPA, Belém, Pará (PA), Brazil
2Department of child health, Metropolitan University Center of the Amazon—FAMAZ, Belém, Pará (PA), Brazil
3Department of Pediatrics, Division of Pediatric Intensive Care, Universidade Federal do Rio Grande do Sul—UFRGS, Porto Alegre (RS), Brazil
4Department of Pediatrics, Division of Pediatric Intensive Care, Fundação Hospital das Clínicas Gaspar Viana’s Hospital—FHCGV, Belém, Pará (PA), Brazil
5Department of Pediatrics, Division of Pediatric Intensive Care, Pró-Infantil’s Hospital—HPI, Belém, Pará (PA), Brazil
6Department of Pediatrics, Division of Pediatric Intensive Care, Pronto Socorro Municipal Mário Pinotti’s Hospital—HPSMMP, Belém, Pará (PA), Brazil

Tóm tắt

We described the characteristics of 11 children with pediatric multisystem inflammatory syndrome-temporally associated with SARS-CoV-2. The main clinical indications for hospital admission were vasogenic toxic shock (n = 2), Kawasaki disease (n = 4), and Kawasaki disease shock syndrome (n = 5). The echocardiography findings were abnormal in 63% of cases. All patients had 2 or more organ dysfunctions, and the mortality rate was 18%.

Từ khóa


Tài liệu tham khảo

Dong, 2020, Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China., Pediatrics, 58, 712

Riphagen, 2020, Hyperinflammatory shock in children during COVID-19 pandemic., Lancet, 395, 1607, 10.1016/S0140-6736(20)31094-1

Verdoni, 2020, An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study., Lancet, 395, 1771, 10.1016/S0140-6736(20)31103-X

Toubiana, 2020, Outbreak of Kawasaki disease in children during COVID-19 pandemic: a prospective observational study in Paris, France., BMJ, 10.1136/bmj.m2094

Farias, 2021, Multisystem inflammatory syndrome in a child associated with coronavirus disease 19 in the Brazilian Amazon: fatal outcome in an infant., Rev Paul Pediatr, 39, e2020165

Whittaker, 2020, Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2., JAMA, 324, 259, 10.1001/jama.2020.10369

Cheung, 2020, Multisystem inflammatory syndrome related to COVID-19 in previously healthy children and adolescents in New York City., JAMA, 324, 294, 10.1001/jama.2020.10374

Feldstein, 2020, Multisystem inflammatory syndrome in U.S. children and adolescents., N Engl J Med, 383, 334, 10.1056/NEJMoa2021680

Ramcharan, 2020, Paediatric inflammatory multisystem syndrome: temporally associated with SARS-CoV-2 (PIMS-TS): cardiac features, management and short-term outcomes at a UK Tertiary Paediatric Hospital., Pediatr Cardiol, 1

Grimaud, 2020, Acute myocarditis and multisystem inflammatory emerging disease following SARS-CoV-2 infection in critically ill children., Ann Intensive Care, 10, 69, 10.1186/s13613-020-00690-8

Gemmati, 2020, COVID-19 and individual genetic susceptibility/receptivity: role of ACE1/ACE2 genes, immunity, inflammation and coagulation. Might the double X-chromosome in females be protective against SARS-CoV-2 compared to the single X-chromosome in males?., Int J Mol Sci, 21, 3474, 10.3390/ijms21103474

Carcillo, 2020, Why and how is hyperferritinemic sepsis different from sepsis without hyperferritinemia?., Pediatr Crit Care Med, 21, 509, 10.1097/PCC.0000000000002285

Kuri-Cervantes, 2020, Immunologic perturbations in severe COVID-19/SARS-CoV-2 infection. Preprint., bioRxiv

Sallenave, 2020, Innate immune signaling and proteolytic pathways in the resolution or exacerbation of SARS-CoV-2 in COVID-19: key therapeutic targets?., Front Immunol, 11, 1229, 10.3389/fimmu.2020.01229