Multiple sclerosis risk loci correlate with cervical cord atrophy and may explain the course of disability

Oksenberg JR, Baranzini SE (2010) Multiple sclerosis genetics–is the glass half full, or half empty? Nat Rev Neurol 6:429–437

Sawcer S et al (2010) What role for genetics in the prediction of multiple sclerosis? Ann Neurol 67:3–10

Gregory AP et al (2012) TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis. Nature 488:508–511

van Oosten BW et al (1996) Increased MRI activity and immune activation in two multiple sclerosis patients treated with the monoclonal anti-tumor necrosis factor antibody cA2. Neurology 47:1531–1534

Liguori M et al (2011) HLA (A-B-C and -DRB1) alleles and brain MRI changes in multiple sclerosis: a longitudinal study. Genes Immun 12:183–190

Imrell K et al (2006) Multiple sclerosis with and without CSF bands: clinically indistinguishable but immunogenetically distinct. Neurology 67:1062–1064

Healy BC et al (2010) HLA B*44: protective effects in MS susceptibility and MRI outcome measures. Neurology 75:634–640

Lill CM et al (2012) Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29,000 subjects. J Med Genet 49:558–562

Sawcer S et al (2011) Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 476:214–219

McDonald WI et al (2001) Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the Diagnosis of Multiple Sclerosis. Ann Neurol 50:121–127

Roxburgh RH et al (2005) Multiple sclerosis severity score: using disability and disease duration to rate disease severity. Neurology 64:1144–1151

Lukas C et al (2013) Relevance of spinal cord abnormalities to clinical disability in multiple sclerosis: MR imaging findings in a large cohort of patients. Radiology 269:542–552

De Jager PL et al (2009) Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score. Lancet Neurol 8:1111–1119

Rocca MA et al (2011) A multicenter assessment of cervical cord atrophy among MS clinical phenotypes. Neurology 76:2096–2102

Shahijanian F et al (2014) The CYP27B1 variant associated with an increased risk of autoimmune disease is underexpressed in tolerizing dendritic cells. Hum Mol Genet 23:1425–1434

Mowry EM et al (2013) Multiple sclerosis susceptibility genes: associations with relapse severity and recovery. PLoS One 8:e75416

Gourraud PA et al (2011) Aggregation of multiple sclerosis genetic risk variants in multiple and single case families. Ann Neurol 69:65–74

Evangelou N et al (2005) Pathological study of spinal cord atrophy in multiple sclerosis suggests limited role of local lesions. Brain: J Neurology 128:29–34

Lukas C. et al (2014) Cervical spinal cord volume loss is related to clinical disability progression in multiple sclerosis. Journal of neurology, neurosurgery, and psychiatry