Multiple Subunits of the <i>Caenorhabditis elegans</i> Anaphase-Promoting Complex Are Required for Chromosome Segregation During Meiosis I

Genetics - Tập 160 Số 2 - Trang 805-813 - 2002
Edward S. Davis1, Lucia Wille2, Barry A. Chestnut1, Penny L. Sadler1, Diane C. Shakes2, Andy Golden1
1*Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0840
2Department of Biology, College of William and Mary, Williamsburg, Virginia 23187

Tóm tắt

Abstract Two genes, originally identified in genetic screens for Caenorhabditis elegans mutants that arrest in metaphase of meiosis I, prove to encode subunits of the anaphase-promoting complex or cyclosome (APC/C). RNA interference studies reveal that these and other APC/C subunits are essential for the segregation of chromosomal homologs during meiosis I. Further, chromosome segregation during meiosis I requires APC/C functions in addition to the release of sister chromatid cohesion.

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