Multiphase surfactant-assisted reaction-separation system in a microchannel reactor
Tóm tắt
The Lewis acid-catalyzed addition of trimethylsilyl cyanide to p-chlorobenzaldehyde in a microchannel reactor was investigated. The microchannel was integrated to promote both reaction and separation of the biphase system. FeF3 and Cu(triflate)2 were used as water-stable Lewis acid catalysts. Sodium dodecyl sulfate was incorporated in the organic-aqueous system to enhance the reactivity and to manipulate the multiphase flow inside the microchannel. It was found that the dynamics and the kinetics of the multiphase reaction were affected by the new micellar system. Parallel multiphase flow inside the microchannel was obtained, allowing for continuous and acceptable phase separation. Enhanced selectivity was achieved by operating at lower conversion values.
Tài liệu tham khảo
citation_journal_title=Chem Rev; citation_title=Organic reactions in aqueous media with a focus on carbon-carbon bond formation; citation_author=C.-J. Li; citation_volume=93; citation_publication_date=1993; citation_pages=2023-2035; citation_doi=10.1021/cr00022a004; citation_id=CR1
citation_journal_title=Chem Rev; citation_title=Stereoselective organic reactions in water; citation_author=U. M. Lindstrom; citation_volume=102; citation_publication_date=2002; citation_pages=2751-2772; citation_doi=10.1021/cr010122p; citation_id=CR2
Kobayashi S, Nagayama S, Busujima T. Lewis acid catalysis in aqueous media: copper (II)-catalyzed aldol and allylation reactions in a water-ethanol-toluene solution. Chem Lett, 1997: 959–960
citation_journal_title=Tetrahedron Letters; citation_title=Lewis acid catalysis in micellar systems: Sc(OTf)3-catalyzed aqueous aldol reactions of silyl enol ethers with aldehydes in the presence of a surfactant; citation_author=S. Kobayashi, T. Wakabayashi, S. Nagayama, H. Oyamada; citation_volume=38; citation_publication_date=1997; citation_pages=4559-4562; citation_doi=10.1016/S0040-4039(97)00854-X; citation_id=CR4
Killer E, Feringa B L. Highly efficient ytterbium triflate catalyzed michael addition of nitroesters in water. Synlett, 1997: 842
citation_journal_title=J Am Chem Soc; citation_title=Lewis acid catalysis of a Diels-Alder reaction in water; citation_author=S. Otto, F. Bertoncin, B. F. N. Engberts; citation_volume=118; citation_publication_date=1996; citation_pages=7702-7707; citation_doi=10.1021/ja960318k; citation_id=CR6
citation_journal_title=Green Chemistry; citation_title=Organic reactions in aqueous medium: FeF3catalyzed chemoselective addition of cyanotrimethylsilane to aldehydes; citation_author=B. P. Bandgar, V. T. Kamble; citation_volume=3; citation_publication_date=2001; citation_pages=265-266; citation_doi=10.1039/b106872p; citation_id=CR7
citation_journal_title=Chem Eng Sci; citation_title=Micro-channel reactor with guideline structure for organic aqueous binary system; citation_author=T. Tagawa, S. Aljbour, M. Matouq, H. Yamada; citation_volume=62; citation_publication_date=2007; citation_pages=5123-5126; citation_doi=10.1016/j.ces.2007.03.015; citation_id=CR8
citation_journal_title=C R Physique; citation_title=Multiphase flows in microfluidics; citation_author=C. N. Baroud, H. Willaime; citation_volume=5; citation_publication_date=2004; citation_pages=547-555; citation_doi=10.1016/j.crhy.2004.04.006; citation_id=CR9
citation_journal_title=Advances in Colloid and Interface Science; citation_title=Multiphase flow in microfluidic systems: control and applications of droplets and interfaces; citation_author=L. Shui, J. C. T. Eijkel, A. Berg; citation_volume=133; citation_publication_date=2007; citation_pages=35-49; citation_doi=10.1016/j.cis.2007.03.001; citation_id=CR10
citation_journal_title=Physical Review; citation_title=Stability of parallel flows in a microchannel after a T junction; citation_author=P. Guuillot, A. Colin; citation_volume=72; citation_publication_date=2005; citation_pages=066301; citation_doi=10.1103/PhysRevA.72.066301; citation_id=CR11
citation_journal_title=Journal of Colloid and interface Science; citation_title=Interfacial stabilization of organic-aqueous twophase microflows for a miniaturized DNA extraction; citation_author=V. Reddy, J. D. Zahn; citation_volume=286; citation_publication_date=2005; citation_pages=158-165; citation_doi=10.1016/j.jcis.2004.12.052; citation_id=CR12
citation_journal_title=Journal of Computational and Applied Mathematics; citation_title=Computational modelling of slug flow in a capillary microreactor; citation_author=M. N. Kashid, F. Platte, D. W. Agar, S. Turek; citation_volume=203; citation_publication_date=2007; citation_pages=487-497; citation_doi=10.1016/j.cam.2006.04.010; citation_id=CR13
citation_journal_title=Adv Synth Catal; citation_title=Enhancement of reaction rates by segmented fluid flow in capillary scale reactors; citation_author=B. Ahmed, D. Barrow, T. Wirth; citation_volume=348; citation_publication_date=2006; citation_pages=1043-1048; citation_doi=10.1002/adsc.200505480; citation_id=CR14