Multimodal strategy to counteract vasodilation in septic shock

De Pascale, 2022, Poor timing and failure of source control are risk factors for mortality in critically ill patients with secondary peritonitis, Intensive Care Med, 48, 1593, 10.1007/s00134-022-06883-y Evans, 2021, Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021, Intensive Care Med, 47, 1181, 10.1007/s00134-021-06506-y Kumar, 2008, Cardiovascular response to dobutamine stress predicts outcome in severe sepsis and septic shock, Crit Care, 12, R35, 10.1186/cc6814 Bassi, 2013, Therapeutic strategies for high-dose vasopressor-dependent shock, Crit Care Res Pract, 2013 Venkatesh, 2019, Less is more: catecholamine-sparing strategies in septic shock, Intensive Care Med, 45, 1810, 10.1007/s00134-019-05770-3 Annane, 2018, A global perspective on vasoactive agents in shock, Intensive Care Med, 44, 833, 10.1007/s00134-018-5242-5 Auchet, 2017, Outcome of patients with septic shock and high-dose vasopressor therapy, Ann Intensive Care, 7, 43, 10.1186/s13613-017-0261-x Martin, 2015, Norepinephrine: not too much, too long, Shock, 44, 305, 10.1097/SHK.0000000000000426 De Backer, 2010, Comparison of dopamine and norepinephrine in the treatment of shock, N Engl J Med, 362, 779, 10.1056/NEJMoa0907118 Asfar, 2014, High versus low blood-pressure target in patients with septic shock, N Engl J Med, 370, 1583, 10.1056/NEJMoa1312173 Wieruszewski, 2022, Vasopressor choice and timing in vasodilatory shock, Crit Care, 26, 76, 10.1186/s13054-022-03911-7 Wieruszewski, 2022, Early multimodal vasopressors—are we ready for it?, Crit Care Med, 50, 705, 10.1097/CCM.0000000000005344 Morelli, 2013, Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial, JAMA J Am Med Assoc, 310, 1683, 10.1001/jama.2013.278477 Cocchi, 2022, Esmolol to treat the hemodynamic effects of septic shock: a randomized controlled trial, Shock, 57, 508, 10.1097/SHK.0000000000001905 Cioccari, 2020, The effect of dexmedetomidine on vasopressor requirements in patients with septic shock: a subgroup analysis of the Sedation Practice in Intensive Care Evaluation [SPICE III] Trial, Crit Care, 24, 441, 10.1186/s13054-020-03115-x Morelli, 2019, The effect of propofol and dexmedetomidine sedation on norepinephrine requirements in septic shock patients: a crossover trial, Crit Care Med, 47, e89, 10.1097/CCM.0000000000003520 Bellissant, 2000, Effect of hydrocortisone on phenylephrine—mean arterial pressure dose–response relationship in septic shock, Clin Pharmacol Ther, 68, 293, 10.1067/mcp.2000.109354 Levy, 2010, Vascular hyporesponsiveness to vasopressors in septic shock: from bench to bedside, Intensive Care Med, 36, 2019, 10.1007/s00134-010-2045-8 Antonucci, 2022, Selepressin in septic shock, Shock (Augusta, Ga), 57, 10.1097/SHK.0000000000001932 Eyenga, 2014, Early septic shock induces loss of oxidative phosphorylation yield plasticity in liver mitochondria, J Physiol Biochem, 70, 285, 10.1007/s13105-013-0280-5 Eyenga, 2022, Regulation of oxidative phosphorylation of liver mitochondria in sepsis, Cells, 11, 1598, 10.3390/cells11101598 Mantzarlis, 2017, Role of oxidative stress and mitochondrial dysfunction in sepsis and potential therapies, Oxid Med Cell Longev, 2017, 10.1155/2017/5985209 Joffre, 2020, Endothelial responses in sepsis, Am J Respir Crit Care Med, 202, 361, 10.1164/rccm.201910-1911TR Murray, 2000, Nitric oxide and septic vascular dysfunction, Anesth Analg, 90, 89, 10.1097/00000539-200001000-00021 Kirov, 2001, Infusion of methylene blue in human septic shock: a pilot, randomized, controlled study, Crit Care Med, 29, 1860, 10.1097/00003246-200110000-00002 Bakker, 2004, Crit Care Med, 32, 1, 10.1097/01.CCM.0000105118.66983.19 López, 2004, Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock, Crit Care Med, 32, 21, 10.1097/01.CCM.0000105581.01815.C6 Michard, 2002, Predicting fluid responsiveness in ICU patients: a critical analysis of the evidence, Chest, 121, 2000, 10.1378/chest.121.6.2000 Funk, 2013, Role of the venous return in critical illness and shock: part II-shock and mechanical ventilation, Crit Care Med, 41, 573, 10.1097/CCM.0b013e31827bfc25 Vincent, 2021, Equilibrating SSC guidelines with individualized care, Crit Care, 25, 397, 10.1186/s13054-021-03813-0 Andreis, 2016, Catecholamines for inflammatory shock: a Jekyll-and-Hyde conundrum, Intensive Care Med, 42, 1387, 10.1007/s00134-016-4249-z Varpula, 2005, Hemodynamic variables related to outcome in septic shock, Intensive Care Med, 31, 1066, 10.1007/s00134-005-2688-z Maheshwari, 2018, The relationship between ICU hypotension and in-hospital mortality and morbidity in septic patients, Intensive Care Med, 44, 857, 10.1007/s00134-018-5218-5 Dünser, 2009, Arterial blood pressure during early sepsis and outcome, Intensive Care Med, 35, 1225, 10.1007/s00134-009-1427-2 Myburgh, 2008, A comparison of epinephrine and norepinephrine in critically ill patients, Intensive Care Med, 34, 2226, 10.1007/s00134-008-1219-0 Russell, 2008, Vasopressin versus norepinephrine infusion in patients with septic shock, N Engl J Med, 358, 877, 10.1056/NEJMoa067373 De Backer, 2003, Effects of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in septic shock: which is best?, Crit Care Med, 31, 1659, 10.1097/01.CCM.0000063045.77339.B6 Vail, 2017, Association between US norepinephrine shortage and mortality among patients with septic shock, JAMA, 317, 1433, 10.1001/jama.2017.2841 Gamper, 2016, Vasopressors for hypotensive shock, Cochrane Database Syst Rev, 2 Delmas, 2005, Clinical review: vasopressin and terlipressin in septic shock patients, Crit Care, 9, 212, 10.1186/cc2945 Nemenoff, 1998, Vasopressin signaling pathways in vascular smooth muscle, Front Biosci, 3, d194, 10.2741/A274 Cooper, 1984, Mechanism of action of vasopressin on prostaglandin synthesis and vascular function in the isolated rat kidney: effect of calcium antagonists and calmodulin inhibitors, J Pharmacol Exp Ther, 229, 139 Marshall, 1993, The influence of vasopressin on the arterioles and venules of skeletal muscle of the rat during systemic hypoxia, J Physiol, 470, 473, 10.1113/jphysiol.1993.sp019870 Morelli, 2011, Effects of vasopressinergic receptor agonists on sublingual microcirculation in norepinephrine-dependent septic shock, Crit Care, 15, R217, 10.1186/cc10453 Nagendran, 2019, Vasopressin in septic shock: an individual patient data meta-analysis of randomised controlled trials, Intensive Care Med, 45, 844, 10.1007/s00134-019-05620-2 Faivre, 2005, Cardiac and renal effects of levosimendan, arginine vasopressin, and norepinephrine in lipopolysaccharide-treated rabbits, Anesthesiology, 103, 514, 10.1097/00000542-200509000-00014 Albanèse, 2005, Terlipressin or norepinephrine in hyperdynamic septic shock: a prospective, randomized study, Crit Care Med, 33, 1897, 10.1097/01.CCM.0000178182.37639.D6 Azzawi, 1983, The effect of vasopressin on renal blood flow and its distribution in the rat, J Physiol, 341, 233, 10.1113/jphysiol.1983.sp014803 Edwards, 1989, Renal microvascular effects of vasopressin and vasopressin antagonists, Am J Physiol, 256, F274 Albert, 2004, Systemic and renal macro- and microcirculatory responses to arginine vasopressin in endotoxic rabbits, Crit Care Med, 32, 1891, 10.1097/01.CCM.0000139708.10718.E3 Paul, 2006, Physiology of local renin-angiotensin systems, Physiol Rev, 86, 747, 10.1152/physrev.00036.2005 Lumlertgul, 2020, Roles of angiotensin II as vasopressor in vasodilatory shock, Future Cardiol, 16, 569, 10.2217/fca-2020-0019 Hall, 2018, Angiotensin in critical care, Crit Care, 22, 69, 10.1186/s13054-018-1995-z Hermanns, 2014, LPS-induced effects on angiotensin I-converting enzyme expression and shedding in human pulmonary microvascular endothelial cells, In Vitro Cell Dev Biol Anim, 50, 287, 10.1007/s11626-013-9707-0 Deitz, 1987, Effects of E. coli endotoxin on rat plasma angiotensin converting enzyme activity in vitro and in vivo, Circ Shock, 21, 23 Cookson, 1985, Angiotensin converting enzyme and endotoxin induced lung damage in the mouse, Thorax, 40, 774, 10.1136/thx.40.10.774 Idell, 1987, Angiotensin converting enzyme in bronchoalveolar lavage in ARDS, Chest, 91, 52, 10.1378/chest.91.1.52 Leśnik, 2022, Renin as a marker of tissue perfusion, septic shock and mortality in septic patients: a prospective observational study, Int J Mol Sci, 23, 9133, 10.3390/ijms23169133 Shariat-Madar, 2004, The plasma kallikrein/kinin and renin angiotensin systems in blood pressure regulation in sepsis, J Endotoxin Res, 10, 3 Hamid, 2020, Role of kinins in hypertension and heart failure, Pharmaceuticals (Basel), 13, E347, 10.3390/ph13110347 Schmid, 1998, Endogenous B1 receptor mediated hypotension produced by contact system activation in the presence of endotoxemia, Immunopharmacology, 40, 131, 10.1016/S0162-3109(98)00038-1 Bellomo, 2020, Angiotensin I and angiotensin II concentrations and their ratio in catecholamine-resistant vasodilatory shock, Crit Care, 24, 43, 10.1186/s13054-020-2733-x Jang, 2013, Methylene blue for distributive shock: a potential new use of an old antidote, J Med Toxicol, 9, 242, 10.1007/s13181-013-0298-7 Tchen, 2020, Clinical utility of midodrine and methylene blue as catecholamine-sparing agents in intensive care unit patients with shock, J Crit Care, 57, 148, 10.1016/j.jcrc.2020.02.011 Memis, 2002, The influence of methylene Blue infusion on cytokine levels during severe sepsis, Anaesth Intensive Care, 30, 755, 10.1177/0310057X0203000606 Porizka, 2020, Methylene blue administration in patients with refractory distributive shock — a retrospective study, Sci Rep, 10, 1828, 10.1038/s41598-020-58828-4 Schneider, 1992, Methylene blue increases systemic vascular resistance in human septic shock. Preliminary observations, Intensive Care Med, 18, 309, 10.1007/BF01706481 Gachot, 1995, Short-term effects of methylene blue on hemodynamics and gas exchange in humans with septic shock, Intensive Care Med, 21, 1027, 10.1007/BF01700666 Andresen, 1998, Use of methylene blue in patients with refractory septic shock: impact on hemodynamics and gas exchange, J Crit Care, 13, 164, 10.1016/S0883-9441(98)90001-6 Preiser, 1995, Methylene blue administration in septic shock: a clinical trial, Crit Care Med, 23, 259, 10.1097/00003246-199502000-00010 Zhao, 2022, Efficacy and safety of methylene blue in patients with vasodilatory shock: a systematic review and meta-analysis, Front Med (Lausanne), 9 Puntillo, 2020, Vasopressor-sparing action of methylene Blue in severe sepsis and shock: a narrative review, Adv Ther, 37, 3692, 10.1007/s12325-020-01422-x Luis-Silva, 2022, Effect of methylene blue on hemodynamic and metabolic response in septic shock patients, Medicine (Baltimore), 101, 10.1097/MD.0000000000028599 Ahn, 2017, Methylene blue inhibits NLRP3, NLRC4, AIM2, and non-canonical inflammasome activation, Sci Rep, 7, 12409, 10.1038/s41598-017-12635-6 Noguera, 1997, Potentiation by vasopressin of adrenergic vasoconstriction in the rat isolated mesenteric artery, Br J Pharmacol, 122, 431, 10.1038/sj.bjp.0701397 Leone, 2006, Decreased vasopressin responsiveness in vasodilatory septic shock-like conditions, Crit Care Med, 34, 1126, 10.1097/01.CCM.0000206466.56669.BE Hidaka, 2005, Marked synergism between vasopressin and angiotensin II in a human isolated artery, Crit Care Med, 33, 2613, 10.1097/01.CCM.0000186759.13325.DC Gao, 2003, Alpha 2-adrenoceptors potentiate angiotensin II- and vasopressin-induced renal vasoconstriction in spontaneously hypertensive rats, J Pharmacol Exp Ther, 305, 581, 10.1124/jpet.102.047647 Pettinger, 2020, α 2-adrenoceptors: challenges and opportunities-enlightenment from the kidney, Cardiovasc Ther, 2020, 10.1155/2020/2478781 Laterre, 2019, Effect of selepressin vs placebo on ventilator- and vasopressor-free days in patients with septic shock: the SEPSIS-ACT randomized clinical trial, JAMA, 322, 1476, 10.1001/jama.2019.14607 Oliveira, 2016, Correlation between arterial blood gas and electrolyte disturbances during hospitalization and outcome in critically ill patients, from the 36th International symposium on intensive care and emergency medicine : Brussels, Belgium. 15–18 March 2016, Crit Care, 20, 94, 10.1186/s13054-016-1208-6 Serpa Neto, 2012, Vasopressin and terlipressin in adult vasodilatory shock: a systematic review and meta-analysis of nine randomized controlled trials, Crit Care, 16, R154, 10.1186/cc11469 Dünser, 2003, Arginine vasopressin in advanced vasodilatory shock: a prospective, randomized, controlled study, Circulation, 107, 2313, 10.1161/01.CIR.0000066692.71008.BB Patel, 2002, Beneficial effects of short-term vasopressin infusion during severe septic shock, Anesthesiology, 96, 576, 10.1097/00000542-200203000-00011 Morelli, 2008, Effects of short-term simultaneous infusion of dobutamine and terlipressin in patients with septic shock: the DOBUPRESS study, Br J Anaesth, 100, 494, 10.1093/bja/aen017 Duclos, 2019, Preliminary results of synergy between norepinephrine and terlipressin during septic shock, Intensive Care Med, 45, 730, 10.1007/s00134-018-05514-9 Clem, 2016, Norepinephrine and vasopressin vs norepinephrine alone for septic shock: randomized controlled trial, Crit Care Med, 44, 413, 10.1097/01.ccm.0000510024.07609.07 Sahoo, 2022, Comparison of norepinephrine and terlipressin vs norepinephrine alone for management of septic shock: a randomized control study, Indian J Crit Care Med, 26, 669, 10.5005/jp-journals-10071-24231 Sharshar, 2003, Circulating vasopressin levels in septic shock, Crit Care Med, 31, 1752, 10.1097/01.CCM.0000063046.82359.4A Rydz, 2022, Early initiation of vasopressin reduces organ failure and mortality in septic shock, Shock, 58, 269, 10.1097/SHK.0000000000001978 Huang, 2021, The effect of early vasopressin use on patients with septic shock: a systematic review and meta-analysis, Am J Emerg Med, 48, 203, 10.1016/j.ajem.2021.05.007 Acevedo, 2009, Clinical efficacy and safety of terlipressin administration in cirrhotic patients with septic shock, J Hepatol, 50, 10.1016/S0168-8278(09)60176-8 Rodriguez, 2020, Novel vasopressors in the treatment of vasodilatory shock: a systematic review of angiotensin II, selepressin, and terlipressin, J Intensive Care Med, 35, 327, 10.1177/0885066618818460 Khanna, 2017, Angiotensin II for the treatment of vasodilatory shock, N Engl J Med, 377, 419, 10.1056/NEJMoa1704154 Wieruszewski, 2021, Angiotensin II infusion for shock: a multicenter study of postmarketing use, Chest, 159, 596, 10.1016/j.chest.2020.08.2074 Chawla, 2014, Intravenous angiotensin II for the treatment of high-output shock (ATHOS trial): a pilot study, Crit Care, 18, 534, 10.1186/s13054-014-0534-9 Tumlin, 2018, Outcomes in patients with vasodilatory shock and renal replacement therapy treated with intravenous angiotensin II, Crit Care Med, 46, 949, 10.1097/CCM.0000000000003092 Watson, 2004, Cardiovascular effects of the nitric oxide synthase inhibitor NG-methyl-l-arginine hydrochloride (546C88) in patients with septic shock: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002), Crit Care Med, 32, 13, 10.1097/01.CCM.0000104209.07273.FC Khanna, 2022, Renin kinetics and mortality—same, same but different?, Crit Care Med, 50, 153, 10.1097/CCM.0000000000005157 Jeyaraju, 2022, Renin kinetics are superior to lactate kinetics for predicting in-hospital mortality in hypotensive critically ill patients, Crit Care Med, 50, 50, 10.1097/CCM.0000000000005143 Gleeson, 2019, Renin as a marker of tissue-perfusion and prognosis in critically ill patients, Crit Care Med, 47, 152, 10.1097/CCM.0000000000003544 Malay, 1999, Low-dose vasopressin in the treatment of vasodilatory septic shock, J Trauma, 47, 699, 10.1097/00005373-199910000-00014 Morelli, 2009, Continuous terlipressin versus vasopressin infusion in septic shock (TERLIVAP): a randomized, controlled pilot study, Crit Care, 13, R130, 10.1186/cc7990 Fonseca-Ruiz, 2013, Uso de vasopresina en pacientes con choque séptico refractario a catecolaminas, Acta Colombiana de Cuidado Intensivo, 13, 114 Barzegar, 2016, the therapeutic role of vasopressin on improving lactate clearance during and after vasogenic shock: microcirculation. Is it the black box?, Acta Med Iran, 54, 15 Chen, 2017, Comparison of effect of norepinephrine and terlipressin on patients with ARDS combined with septic shock: a prospective single-blind randomized controlled trial, Zhonghua Wei Zhong Bing Ji Jiu Yi Xue, 29, 111 Hammond, 2018, Prospective open-label trial of early concomitant vasopressin and norepinephrine therapy versus initial norepinephrine monotherapy in septic shock, Pharmacotherapy, 38, 531, 10.1002/phar.2105 Wang, 2022, Addition of terlipressin to norepinephrine in septic shock and effect of renal perfusion: a pilot study, Ren Fail, 44, 1207, 10.1080/0886022X.2022.2095286