Multimodal on-axis platform for all-optical electrophysiology with near-infrared probes in human stem-cell-derived cardiomyocytes

Abdelfattah, 2016, A bright and fast red fluorescent protein voltage indicator that reports neuronal activity in organotypic brain slices, J. Neurosci., 36, 2458, 10.1523/JNEUROSCI.3484-15.2016 Ambrosi, 2014, Optogenetic control of cardiomyocytes via viral delivery, Methods Mol. Biol., 1181, 215, 10.1007/978-1-4939-1047-2_19 Ambrosi, 2015, Optogenetics-enabled assessment of viral gene and cell therapy for restoration of cardiac excitability, Sci. Rep., 5, 17350, 10.1038/srep17350 Bamann, 2008, Spectral characteristics of the photocycle of channelrhodopsin-2 and its implication for channel function, J. Mol. Biol., 375, 686, 10.1016/j.jmb.2007.10.072 Bien, 2006, Calcium instabilities in Mammalian cardiomyocyte networks, Biophys. J., 90, 2628, 10.1529/biophysj.105.063321 Blinova, 2017, Comprehensive translational assessment of human-induced pluripotent stem cell derived cardiomyocytes for evaluating drug-induced arrhythmias, Toxicol. Sci.: Off. J. Soc. Toxicol., 155, 234, 10.1093/toxsci/kfw200 Burton, 2015, Optical control of excitation waves in cardiac tissue, Nat. Photon., 9, 813, 10.1038/nphoton.2015.196 Chamberland, 2017, Fast two-photon imaging of subcellular voltage dynamics in neuronal tissue with genetically encoded indicators, eLife, 6, 10.7554/eLife.25690 Chen, 2013, Ultrasensitive fluorescent proteins for imaging neuronal activity, Nature, 499, 295, 10.1038/nature12354 Choi, 2000, Simultaneous maps of optical action potentials and calcium transients in Guinea-pig hearts: mechanisms underlying concordant alternans, J. Physiol., 529 Pt 1, 171, 10.1111/j.1469-7793.2000.00171.x Chung, 2011, Hypertrophic phenotype in cardiac cell assemblies solely by structural cues and ensuing self-organization, FASEB J., 25, 851, 10.1096/fj.10-168625 Dana, 2016, Sensitive red protein calcium indicators for imaging neural activity, eLife, 5, 10.7554/eLife.12727 Dempsey, 2016, Cardiotoxicity screening with simultaneous optogenetic pacing, voltage imaging and calcium imaging, J. Pharmacol. Toxicol. Methods, 81, 240, 10.1016/j.vascn.2016.05.003 Entcheva, 2006, Macroscopic optical mapping of excitation in cardiac cell networks with ultra-high spatiotemporal resolution, Prog. Biophys. Mol. Biol., 92, 232, 10.1016/j.pbiomolbio.2005.10.003 Entcheva, 2016, All-optical control of cardiac excitation: combined high-resolution optogenetic actuation and optical mapping, J. Physiol., 594, 2503, 10.1113/JP271559 Entcheva, 2004, Fluorescence imaging of electrical activity in cardiac cells using an all-solid-state system, IEEE Trans. Biomed. Eng., 51, 333, 10.1109/TBME.2003.820376 Fast, 2000, Simultaneous optical mapping of transmembrane potential and intracellular calcium in myocyte cultures, J. Cardiovasc. Electrophysiol., 11, 547, 10.1111/j.1540-8167.2000.tb00008.x Fertig, 2010, Renaissance of ion channel research and drug discovery by patch clamp automation, Future Med. Chem., 2, 691, 10.4155/fmc.10.183 Gintant, 2016, Evolution of strategies to improve preclinical cardiac safety testing, Nat. Rev. Drug Discov., 15, 457, 10.1038/nrd.2015.34 Harris, 2013, Comparison of electrophysiological data from human-induced pluripotent stem cell-derived cardiomyocytes to functional preclinical safety assays, Toxicol. Sci.: Off. J. Soc. Toxicol., 134, 412, 10.1093/toxsci/kft113 Herron, 2012, Optical imaging of voltage and calcium in cardiac cells & tissues, Circ. Res., 110, 609, 10.1161/CIRCRESAHA.111.247494 Hochbaum, 2014, All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins, Nat. Methods, 11, 825, 10.1038/nmeth.3000 Huang, 2015, A photostable silicon rhodamine platform for optical voltage sensing, J. Am. Chem. Soc., 137, 10767, 10.1021/jacs.5b06644 Jia, 2011, Stimulating cardiac muscle by LightClinical perspective cardiac optogenetics by cell delivery, Circulation: Arrhythmia and Electrophysiol., 4, 753 Klimas, 2014, Toward microendoscopy-inspired cardiac optogenetics in vivo: technical overview and perspective, J. Biomed. Optic., 19, 80701, 10.1117/1.JBO.19.8.080701 Klimas, 2016, OptoDyCE as an automated system for high-throughput all-optical dynamic cardiac electrophysiology, Nat. Commun., 7, 11542, 10.1038/ncomms11542 Laurita, 2001, Mapping action potentials and calcium transients simultaneously from the intact heart, Am. J. Physiol. Heart Circ. Physiol., 280, 2053, 10.1152/ajpheart.2001.280.5.H2053 Lee, 2017, Biophysical characterization of genetically encoded voltage sensor ASAP1: dynamic range improvement, Biophys. J., 113, 2178, 10.1016/j.bpj.2017.10.018 Lee, 2011, Single-sensor system for spatially resolved, continuous, and multiparametric optical mapping of cardiac tissue, Heart Rhythm, 8, 1482, 10.1016/j.hrthm.2011.03.061 Lee, 2012, Simultaneous voltage and calcium mapping of genetically purified human induced pluripotent stem cell-derived cardiac myocyte monolayers, Circ. Res., 110, 1556, 10.1161/CIRCRESAHA.111.262535 Li, 2016, Cardiotoxicity screening: a review of rapid-throughput in vitro approaches, Arch. Toxicol., 90, 1803, 10.1007/s00204-015-1651-1 Matiukas, 2007, Near-infrared voltage-sensitive fluorescent dyes optimized for optical mapping in blood-perfused myocardium, Heart Rhythm, 4, 1441, 10.1016/j.hrthm.2007.07.012 McKeithan, 2017, An Automated platform for assessment of congenital and drug-induced arrhythmia with hipsc-derived cardiomyocytes, Front. Physiol., 8, 1, 10.3389/fphys.2017.00766 Mutoh, 2013, Probing neuronal activities with genetically encoded optical indicators: from a historical to a forward-looking perspective, Pflügers Archiv, 465, 361, 10.1007/s00424-012-1202-z Nagel, 2003, Channelrhodopsin-2, a directly light-gated cation-selective membrane channel, Proc. Natl. Acad. Sci. U. S. A., 100, 13940, 10.1073/pnas.1936192100 Quach, 2018, Light-activated dynamic clamp using iPSC-derived cardiomyocytes, Biophys. J., 115, 2206, 10.1016/j.bpj.2018.10.018 Shiferaw, 2005, Coupled dynamics of voltage and calcium in paced cardiac cells, Phys. Rev. E - Stat. Nonlinear Soft Matter Phys., 71, 10.1103/PhysRevE.71.021903 St-Pierre, 2014, High-fidelity optical reporting of neuronal electrical activity with an ultrafast fluorescent voltage sensor, Nat. Neurosci., 17, 884, 10.1038/nn.3709 Xu, 2018, Excitation wavelength optimization improves photostability of ASAP-family GEVIs, Mol. Brain, 11, 32, 10.1186/s13041-018-0374-7 Yamamoto, 2016, Electrophysiological characteristics of human iPSC-derived cardiomyocytes for the assessment of drug-induced proarrhythmic potential, PLoS One, 11, e0167348, 10.1371/journal.pone.0167348 Zhao, 2011, An expanded palette of genetically encoded Ca2+ indicators, Science, 333, 1888, 10.1126/science.1208592