Multimodal imaging and photothermal/chemodynamic therapy of cervical cancer using GSH-responsive MoS2@MnO2 theranostic nanoparticles
Tóm tắt
The development of nanoparticles capable of inducing reactive oxygen species (ROS) formation has become an important strategy for cancer therapy. Simultaneously, the preparation of multifunctional nanoparticles that respond to the tumor microenvironment is crucial for the diagnosis and treatment of tumors. In this study, we designed a Molybdenum disulfide (MoS2) core coated with Manganese dioxide (MnO2), which possessed a good photothermal effect and could produce Fenton-like Mn2+ in response to highly expressed glutathione (GSH) in the tumor microenvironment, thereby generating a chemodynamic therapy (CDT). The nanoparticles were further modified with Methoxypoly(Ethylene Glycol) 2000 (mPEG-NH2) to improve their biocompatibility, resulting in the formation of MoS2@MnO2-PEG. These nanoparticles were shown to possess significant Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) imaging capabilities, making them useful in tumor diagnosis. In vitro and in vivo experiments demonstrated the antitumor ability of MoS2@MnO2-PEG, with a significant killing effect on tumor cells under combined treatment. These nanoparticles hold great potential for CDT/photothermal therapy (PTT) combined antitumor therapy and could be further explored in biomedical research.
Tài liệu tham khảo
Medina-Alarcón KP, Voltan AR, Fonseca-Santos B, Moro IJ, de Oliveira Souza F, Chorilli M, Soares CP, Dos Santos AG, Mendes-Giannini MJ, Fusco-Almeida AM. Highlights in nanocarriers for the treatment against cervical cancer. Mater Sci Eng C. 2017;80:748–59. https://doi.org/10.1016/j.msec.2017.07.021.
Li L, Yang S, Song L, et al. An endogenous vaccine based on fluorophores and multivalent immunoadjuvants regulates tumor micro-environment for synergistic photothermal and immunotherapy. Theranostics. 2018;8:860–73. https://doi.org/10.7150/thno.19826.
Mhaidly R, Mechta-Grigoriou F. Fibroblast heterogeneity in tumor micro-environment: role in immunosuppression and new therapies. Semin Immunol. 2020;48:101417. https://doi.org/10.1016/j.smim.2020.101417.
Liu C, Jia S, Tu L, et al. GSH-responsive and hypoxia-activated multifunctional nanoparticles for synergetically enhanced tumor therapy. Acs Biomater Sci Eng. 2022;8:1942–55. https://doi.org/10.1021/acsbiomaterials.2c00076.
Mo J, Zou Y, Li B-H, et al. Tumor-associated extracellular microvesicles with fluorine-modified carbohydrate antigens trigger a stronger antitumor immune response. ACS Appl Mater Interfaces Acsami. 2023. https://doi.org/10.1021/acsami.3c06399.
Li L, Lin Z, Xu X, et al. A pH/GSH/glucose responsive nanozyme for tumor cascade amplified starvation and chemodynamic theranostics. ACS Appl Mater Interfaces. 2023. https://doi.org/10.1021/acsami.3c05412.
Zhu D, Zhu X-H, Ren S-Z, et al. Manganese dioxide (MnO2) based nanomaterials for cancer therapies and theranostics. J Drug Target. 2021;29:911–24. https://doi.org/10.1080/1061186X.2020.1815209.
Pidamaimaiti G, Huang X, Pang K, et al. A microenvironment-mediated Cu2O-MoS2 nanoplatform with enhanced Fenton-like reaction activity for tumor chemodynamic/photothermal therapy. New J Chem. 2021;45:10296–302. https://doi.org/10.1039/d1nj01272j.
Cao W, Jin M, Yang K, et al. Fenton/Fenton-like metal-based nanomaterials combine with oxidase for synergistic tumor therapy. J Nanobiotechnology. 2021;19:325. https://doi.org/10.1186/s12951-021-01074-1.
Bai S, Yang N, Wang X, et al. Ultrasmall iron-doped titanium oxide nanodots for enhanced sonodynamic and chemodynamic cancer therapy. ACS Nano. 2020;14:15119–30. https://doi.org/10.1021/acsnano.0c05235.
Zhu X, Wang M, Wang H, et al. Multifunctional hollow MnO2@Porphyrin@Bromelain nanoplatform for enhanced photodynamic therapy. Small. 2022. https://doi.org/10.1002/smll.202204951.
Zhang W, Ding M, Zhang H, et al. Tumor acidity and near-infrared light responsive drug delivery MoS2-based nanoparticles for chemo-photothermal therapy. Photodiagnosis Photodyn Ther. 2022;38:102716. https://doi.org/10.1016/j.pdpdt.2022.102716.
Peng M-Y, Zheng D-W, Wang S-B, et al. Multifunctional nanosystem for synergistic tumor therapy delivered by two-dimensional MoS2. Acs Appl Mater Interfaces. 2017;9:13965–75. https://doi.org/10.1021/acsami.7b03276.
Tang Z, Zhang H, Liu Y, et al. Antiferromagnetic pyrite as the tumor microenvironment-mediated nanoplatform for self-enhanced tumor imaging and therapy. Adv Mater. 2017;29:1701683. https://doi.org/10.1002/adma.201701683.
Wang J, Sui L, Huang J, et al. MoS2-based nanocomposites for cancer diagnosis and therapy. Bioact Mater. 2021;6:4209–42. https://doi.org/10.1016/j.bioactmat.2021.04.021.
Chen S, Lei Q, Qiu W-X, et al. Mitochondria-targeting “Nanoheater” for enhanced photothermal/chemo-therapy. Biomaterials. 2017;117:92–104. https://doi.org/10.1016/j.biomaterials.2016.11.056.
Feng Y, Zhang H, Xie X, et al. Cascade-activatable NO release based on GSH-detonated “nanobomb” for multi-pathways cancer therapy. Mater Today Bio. 2022;14:100288. https://doi.org/10.1016/j.mtbio.2022.100288.
He H, Yang Q, Li H, et al. Hollow mesoporous MnO2-carbon nanodot-based nanoplatform for GSH depletion enhanced chemodynamic therapy, chemotherapy, and normal/cancer cell differentiation. Microchim Acta. 2021;188:141. https://doi.org/10.1007/s00604-021-04801-5.
Yi X, Chen L, Zhong X, et al. Core-shell Au@MnO2 nanoparticles for enhanced radiotherapy via improving the tumor oxygenation. Nano Res. 2016;9:3267–78. https://doi.org/10.1007/s12274-016-1205-8.
Chu Z, Tian T, Tao Z, et al. Upconversion nanoparticles@AgBiS2 core-shell nanoparticles with cancer-cell-specific cytotoxicity for combined photothermal and photodynamic therapy of cancers. Bioact Mater. 2022;17:71–80. https://doi.org/10.1016/j.bioactmat.2022.01.010.
Li M, Zhao Q, Yi X, et al. Au@MnS@ZnS core/shell/shell nanoparticles for magnetic resonance imaging and enhanced cancer radiation therapy. Acs Appl Mater Interfaces. 2016;8:9557–64. https://doi.org/10.1021/acsami.5b11588.
Hu H, Xiao C, Wu H, et al. Nanocolloidosomes with selective drug release for active tumor-targeted imaging-guided photothermal/chemo combination therapy. Acs Appl Mater Interfaces. 2017;9:42225–38. https://doi.org/10.1021/acsami.7b14796.
Hsieh MH, Wang TH, Hu SH, et al. Tumor site-specific PEG detachment and active tumor homing of therapeutic PEGylated chitosan/folate-decorated polydopamine nanoparticles to augment antitumor efficacy of photothermal/chemo combination therapy. Chem Eng J. 2022;446:137243. https://doi.org/10.1016/j.cej.2022.137243.
Hung YN, Liu YL, Chou YH, et al. Promoted cellular uptake and intracellular cargo release of ICG/DOX-carrying hybrid polymeric nanoassemblies upon acidity-activated PEG detachment to enhance cancer photothermal/chemo combination therapy. Eur Polym J. 2022;163:110944. https://doi.org/10.1016/j.eurpolymj.2021.110944.
Gao Y, Yin Z, Ji Q, et al. Black titanium dioxide@manganese dioxide for glutathione-responsive MR imaging and enhanced photothermal therapy. J Mater Chem B. 2021;9:314–21. https://doi.org/10.1039/d0tb02514c.
Wang D, Zhang N, Jing X, et al. RETRACTION: a tumor-microenvironment fully responsive nano-platform for MRI-guided photodynamic and photothermal synergistic therapy (Retraction of Vol 8, Pg 8271, 2020). J Mater Chem B. 2022;10:9466–7. https://doi.org/10.1039/d2tb90174a.
Shen Z, Song J, Yung BC, et al. Emerging strategies of cancer therapy based on ferroptosis. Adv Mater. 2018;30:1704007. https://doi.org/10.1002/adma.201704007.
Torabi M, Yaghoobi F, Karimi Shervedani R, et al. Mn(II) & Gd(III) deferrioxamine complex contrast agents & temozolomide cancer prodrug immobilized on folic acid targeted graphene/polyacrylic acid nanocarrier: MRI efficiency, drug stability & interactions with cancer cells. Colloids Surf Physicochem Eng Asp. 2022;652:129797. https://doi.org/10.1016/j.colsurfa.2022.129797.
Zhang M, Liu X, Luo Q, et al. Tumor environment responsive degradable CuS@mSiO2@MnO2/DOX for MRI guided synergistic chemo-photothermal therapy and chemodynamic therapy. Chem Eng J. 2020;389:124450. https://doi.org/10.1016/j.cej.2020.124450.
Hosseini M, Ahmadi Z, Kefayat A, et al. Multifunctional gold helix phototheranostic biohybrid that enables targeted image-guided photothermal therapy in breast cancer. ACS Appl Mater Interfaces. 2022;14:37447–65. https://doi.org/10.1021/acsami.2c10028.