Multifunctional carbon nanomaterials for diagnostic applications in infectious diseases and tumors

Stadler, 2003, SARS — beginning to understand a new virus, Nat. Rev. Microbiol., 1, 209, 10.1038/nrmicro775 Memish, 2020, Middle East respiratory syndrome, Lancet, 395, 1063, 10.1016/S0140-6736(19)33221-0 Zhu, 2020, A novel coronavirus from patients with pneumonia in China, 2019, N. Engl. J. Med., 382, 727, 10.1056/NEJMoa2001017 Payandehpeyman, 2021, Detection of SARS-CoV-2 using antibody–antigen interactions with graphene-based nanomechanical resonator sensors, ACS Appl. Nano Mater., 4, 6189, 10.1021/acsanm.1c00983 Mehra, 2018, Carbon nanomaterials in oncology: an expanding horizon, Drug Discov. Today, 23, 1016, 10.1016/j.drudis.2017.09.013 He, 2016, Photoluminescence architectures for disease diagnosis: from graphene to thin-layer transition metal dichalcogenides and oxides, Small, 12, 144, 10.1002/smll.201502516 Gill, 2019, Nanomaterial-based optical and electrochemical techniques for detection of methicillin-resistant Staphylococcus aureus: a review, Microchim. Acta, 186, 114, 10.1007/s00604-018-3186-7 Kaneti, 2019, Self-sacrificial templated synthesis of a three-dimensional hierarchical macroporous honeycomb-like ZnO/ZnCo2O4 hybrid for carbon monoxide sensing, J. Mater. Chem., 7, 3415, 10.1039/C8TA11380G Wen, 2015, Recent applications of carbon nanomaterials in fluorescence biosensing and bioimaging, Chem. Commun., 51, 11346, 10.1039/C5CC02887F Teradal, 2017, Carbon nanomaterials in biological studies and biomedicine, Adv. Healthc. Mater., 6, 1700574, 10.1002/adhm.201700574 Huth, 2018, Fluorescent polymer—single-walled carbon nanotube complexes with charged and noncharged dendronized perylene bisimides for bioimaging studies, Small, 14, 1800796, 10.1002/smll.201800796 Gonzalez-Rodriguez, 2019, Multifunctional graphene oxide/iron oxide nanoparticles for magnetic targeted drug delivery dual magnetic resonance/fluorescence imaging and cancer sensing, PLoS One, 14, 10.1371/journal.pone.0217072 Xu, 2018, Fluorescent and photoacoustic bifunctional probe for the detection of ascorbic acid in biological fluids, living cells and: in vivo, Nanoscale, 10, 17834, 10.1039/C8NR03435D Lei, 2017, Fluorophore-functionalized graphene oxide with application in cell imaging, New J. Chem., 41, 12375, 10.1039/C7NJ02416A Sebaa, 2013, Graphene and carbon nanotube-graphene hybrid nanomaterials for human embryonic stem cell culture, Mater. Lett., 92, 122, 10.1016/j.matlet.2012.10.035 Yan, 2016, Graphene/single-walled carbon nanotube hybrids promoting osteogenic differentiation of mesenchymal stem cells by activating p38 signaling pathway, Int. J. Nanomed., 11, 5473, 10.2147/IJN.S115468 Kang, 2017, Gold nanoparticle/graphene oxide hybrid sheets attached on mesenchymal stem cells for effective photothermal cancer therapy, Chem. Mater., 29, 3461, 10.1021/acs.chemmater.6b05164 Selvarajan, 2018, A simple sonochemical approach to fabricate a urea biosensor based on zinc phthalocyanine/graphene oxide/urease bioelectrode, Ultrason. Sonochem., 42, 183, 10.1016/j.ultsonch.2017.11.030 Pilas, 2019, Screen-printed carbon electrodes modified with graphene oxide for the design of a reagent-free NAD+-dependent biosensor array, Anal. Chem., 91, 15293, 10.1021/acs.analchem.9b04481 Zhu, 2021, Colorimetric detection of immunomagnetically captured rare number CTCs using mDNA-wrapped single-walled carbon nanotubes, Biosens. Bioelectron., 172, 112780, 10.1016/j.bios.2020.112780 Mohajeri, 2018, Biomedical applications of carbon nanomaterials: drug and gene delivery potentials, J. Cell. Physiol., 234, 298, 10.1002/jcp.26899 Tajik, 2020, Carbon and graphene quantum dots: a review on syntheses, characterization, biological and sensing applications for neurotransmitter determination, RSC Adv., 10, 15406, 10.1039/D0RA00799D Coyuco, 2011, Functionalized carbon nanomaterials: exploring the interactions with Caco-2 cells for potential oral drug delivery, Int. J. Nanomed., 6, 2253 Biju, 2014, Chemical modifications and bioconjugate reactions of nanomaterials for sensing, imaging, drug delivery and therapy, Chem. Soc. Rev., 43, 744, 10.1039/C3CS60273G Chen, 2015, Theranostic applications of carbon nanomaterials in cancer: focus on imaging and cargo delivery, J. Contr. Release, 210, 230, 10.1016/j.jconrel.2015.04.021 Shibu, 2013, Nanomaterials formulations for photothermal and photodynamic therapy of cancer, J. Photochem. Photobiol. C Photochem. Rev., 15, 53, 10.1016/j.jphotochemrev.2012.09.004 Jiang, 2019, Recent advances in carbon nanomaterials for cancer phototherapy, Chem. Eur J., 25, 3993, 10.1002/chem.201804383 Taheri, 2020, Photocatalytically active graphitic carbon nitride as an effective and safe 2D material for in vitro and in vivo photodynamic therapy, Small, 16, 1904619, 10.1002/smll.201904619 Patel, 2019, Carbon-based nanomaterials as an emerging platform for theranostics, Mater. Horizons., 6, 434, 10.1039/C8MH00966J Hwang, 2020, Carbon nanomaterials as versatile platforms for biosensing applications, Micromachines, 11, 814, 10.3390/mi11090814 Yadav, 2020, Few biomedical applications of carbon nanotubes, Methods Enzymol., 630, 347, 10.1016/bs.mie.2019.11.005 Roldo, 2013, Biomedical applications of carbon nanotubes, Annu. Reports Prog. Chem. - Sect. C., 109, 10, 10.1039/c3pc90010j Chen, 2014, Interplay of wall number and diameter on the electrical conductivity of carbon nanotube thin films, Carbon, 67, 318, 10.1016/j.carbon.2013.10.001 Pandey, 2021, Carbon nanotubes, graphene, and carbon dots as electrochemical biosensing composites, Molecules, 26, 6674, 10.3390/molecules26216674 Luo, 2018, SWCNTs@GQDs composites as nanocarriers for enzyme-free dual-signal amplification electrochemical immunoassay of cancer biomarker, Anal. Chim. Acta, 1042, 44, 10.1016/j.aca.2018.08.023 Sabahi, 2020, Electrochemical nano-genosensor for highly sensitive detection of miR-21 biomarker based on SWCNT-grafted dendritic Au nanostructure for early detection of prostate cancer, Talanta, 209, 120595, 10.1016/j.talanta.2019.120595 do Quyen Chau, 2015, Multifunctional carbon nanomaterial hybrids for magnetic manipulation and targeting, Biochem. Biophys. Res. Commun., 468, 454, 10.1016/j.bbrc.2015.06.131 Singh, 2014, Multifunctional hybrid nanocarrier: magnetic CNTs ensheathed with mesoporous silica for drug delivery and imaging system, ACS Appl. Mater. Interfaces, 6, 2201, 10.1021/am4056936 Ehtesabi, 2020, Application of carbon nanomaterials in human virus detection, J. Sci. Adv. Mater. Devices., 5, 436, 10.1016/j.jsamd.2020.09.005 Zhang, 2020, Gold-nanourchin seeded single-walled carbon nanotube on voltammetry sensor for diagnosing neurogenerative Parkinson's disease, Anal. Chim. Acta, 1094, 142, 10.1016/j.aca.2019.10.012 Ishibashi, 2017, Adsorption of DNA binding proteins to functionalized carbon nanotube surfaces with and without DNA wrapping, Eur. Biophys. J., 46, 541, 10.1007/s00249-017-1200-3 Masud, 2019, Superparamagnetic nanoarchitectures for disease-specific biomarker detection, Chem. Soc. Rev., 48, 5717, 10.1039/C9CS00174C Wan, 2020, Laser induced self-N-doped porous graphene as an electrochemical biosensor for femtomolar miRNA detection, Carbon, 163, 385, 10.1016/j.carbon.2020.03.043 Hong, 2015, Carbon nanomaterials for biological imaging and nanomedicinal therapy, Chem. Rev., 115, 10816, 10.1021/acs.chemrev.5b00008 Huang, 2014, Carbon nanotube signal amplification for ultrasensitive fluorescence polarization detection of DNA methyltransferase activity and inhibition, Biosens. Bioelectron., 54, 285, 10.1016/j.bios.2013.10.065 Zhang, 2018, Magnetofluorescent Fe3O4/carbon quantum dots coated single-walled carbon nanotubes as dual-modal targeted imaging and chemo/photodynamic/photothermal triple-modal therapeutic agents, Chem. Eng. J., 338, 526, 10.1016/j.cej.2018.01.081 Cui, 2004, Effects of single-walled carbon nanotubes on the polymerase chain reaction, Nanotechnology, 15, 154, 10.1088/0957-4484/15/1/030 Zhang, 2021, A sensitive biomolecules detection device with catalytic hairpin assembly and cationic conjugated polymer-assisted dual signal amplification strategy, Talanta, 223, 121716, 10.1016/j.talanta.2020.121716 Liu, 2008, PEGylated nanographene oxide for delivery of water-insoluble cancer drugs, J. Am. Chem. Soc., 130, 10876, 10.1021/ja803688x Wu, 2018, Boosting carrier mobility of synthetic few layer graphene on SiO2 by interlayer rotation and decoupling, Adv. Mater. Interfac., 5, 1800454, 10.1002/admi.201800454 Li, 2021, A HiPAD integrated with rGO/MWCNTs nano-circuit heater for visual point-of-care testing of SARS-CoV-2, Adv. Funct. Mater., 31, 2100801, 10.1002/adfm.202100801 Zhao, 2016, Investigation on fluorescence quenching mechanism of perylene diimide dyes by graphene oxide, Molecules, 21, 1642, 10.3390/molecules21121642 Mouhat, 2020, Structure and chemistry of graphene oxide in liquid water from first principles, Nat. Commun., 11, 1566, 10.1038/s41467-020-15381-y Maiti, 2019, Carbon-based nanomaterials for biomedical applications: a recent study, Front. Pharmacol., 9, 1401, 10.3389/fphar.2018.01401 Dehghani, 2020, Whole cell FRET immunosensor based on graphene oxide and graphene dot for Campylobacter jejuni detection, Food Chem., 309, 125690, 10.1016/j.foodchem.2019.125690 Fan, 2018, The Distribution and imaging of 99mTc-nGO-PEG-FA in human patu8988 tumor-bearing nude mice, Cancer Biother, Radiopharm, 33, 445 Toumia, 2018, Performances of a pristine graphene–microbubble hybrid construct as dual imaging contrast agent and assessment of its biodistribution by photoacoustic imaging, Part. Part. Syst. Char., 35, 1800066, 10.1002/ppsc.201800066 yue Wang, 2020, Integration of nanomaterials with nucleic acid amplification approaches for biosensing, TrAC Trends Anal. Chem. (Reference Ed.), 129, 115959, 10.1016/j.trac.2020.115959 Li, 2020, Effects of graphene oxide on PCR amplification for microbial community survey, BMC Microbiol., 20, 278, 10.1186/s12866-020-01965-7 Li, 2021, Rapid and unamplified identification of COVID-19 with morpholino-modified graphene field-effect transistor nanosensor, Biosens. Bioelectron., 183, 113206, 10.1016/j.bios.2021.113206 Novodchuk, 2021, An ultrasensitive heart-failure BNP biosensor using B/N co-doped graphene oxide gel FET, Biosens. Bioelectron., 180, 113114, 10.1016/j.bios.2021.113114 Xu, 2004, Electrophoretic analysis and purification of fluorescent single-walled carbon nanotube fragments, J. Am. Chem. Soc., 126, 12736, 10.1021/ja040082h Ji, 2020, Recent developments of carbon dots in biosensing: a review, ACS Sens., 5, 2724, 10.1021/acssensors.0c01556 Li, 2018, Near-infrared excitation/emission and multiphoton-induced fluorescence of carbon dots, Adv. Mater., 30, 1705913, 10.1002/adma.201705913 Su, 2018, Immobilization of horseradish peroxidase on amino-functionalized carbon dots for the sensitive detection of hydrogen peroxide, Microchim. Acta, 185, 114, 10.1007/s00604-017-2629-x Gao, 2017, Development of Gd3N@C80 encapsulated redox nanoparticles for high-performance magnetic resonance imaging, J. Biomater. Sci. Polym. Ed., 28, 1036, 10.1080/09205063.2017.1288774 Kour, 2020, Review—recent advances in carbon nanomaterials as electrochemical biosensors, J. Electrochem. Soc., 167, 10.1149/1945-7111/ab6bc4 Seo, 2020, Microfluidic neurotransmitters sensor in blood plasma with mediator-immobilized conducting polymer/N, S-doped porous carbon composite, Sensor. Actuator. B Chem., 313, 128017, 10.1016/j.snb.2020.128017 Wang, 2015, Carbon nanomaterial-based electrochemical biosensors: an overview, Nanoscale, 7, 6420, 10.1039/C5NR00585J Chen, 2018, Amperometric DNA biosensor for Mycobacterium tuberculosis detection using flower-like carbon nanotubes-polyaniline nanohybrid and enzyme-assisted signal amplification strategy, Biosens. Bioelectron., 119, 215, 10.1016/j.bios.2018.08.023 Zhao, 2021, Ultrasensitive supersandwich-type electrochemical sensor for SARS-CoV-2 from the infected COVID-19 patients using a smartphone, Sensor. Actuator. B Chem., 327, 128899, 10.1016/j.snb.2020.128899 Bai, 2019, Ultrasensitive electrochemical detection of Mycobacterium tuberculosis IS6110 fragment using gold nanoparticles decorated fullerene nanoparticles/nitrogen-doped graphene nanosheet as signal tags, Anal. Chim. Acta, 1080, 75, 10.1016/j.aca.2019.06.043 Zuo, 2020, An efficient electrochemical assay for miR-3675-3p in human serum based on the nanohybrid of functionalized fullerene and metal-organic framework, Anal. Chim. Acta, 1140, 78, 10.1016/j.aca.2020.10.017 Zheng, 2019, Aptamer-DNA concatamer-quantum dots based electrochemical biosensing strategy for green and ultrasensitive detection of tumor cells via mercury-free anodic stripping voltammetry, Biosens. Bioelectron., 126, 261, 10.1016/j.bios.2018.09.076 Jamei, 2021, Ultra-sensitive and selective electrochemical biosensor with aptamer recognition surface based on polymer quantum dots and C60/MWCNTs- polyethylenimine nanocomposites for analysis of thrombin protein, Bioelectrochemistry, 138, 107701, 10.1016/j.bioelechem.2020.107701 Hussein, 2021, SARS-CoV-2-impedimetric biosensor: virus-imprinted chips for early and rapid diagnosis, ACS Sens., 6, 4098, 10.1021/acssensors.1c01614 Torrente-Rodríguez, 2020, A graphene-based multiplexed telemedicine platform for rapid and low-cost COVID-19 diagnosis and monitoring, Matter, 3, 10.1016/j.matt.2020.09.027 Pothipor, 2021, An electrochemical biosensor for simultaneous detection of breast cancer clinically related microRNAs based on a gold nanoparticles/graphene quantum dots/graphene oxide film, Analyst, 146, 4000, 10.1039/D1AN00436K Jafari, 2018, Breast cancer diagnosis: imaging techniques and biochemical markers, J. Cell. Physiol., 233, 5200, 10.1002/jcp.26379 Hwang, 2021, Ultrasensitive detection of dopamine, IL-6 and SARS-CoV-2 proteins on crumpled graphene FET biosensor, Adv. Mater. Technol., 6, 1, 10.1002/admt.202100712 Zhang, 2019, Recent advances of porous graphene: synthesis, functionalization, and electrochemical applications, Small, 15, 1903780, 10.1002/smll.201903780 Shao, 2021, Rapid detection of SARS-CoV-2 antigens using high-purity semiconducting single-walled carbon nanotube-based field-effect transistors, ACS Appl. Mater. Interfaces, 13, 10321, 10.1021/acsami.0c22589 Seo, 2020, Rapid detection of COVID-19 causative virus (SARS-CoV-2) in human nasopharyngeal swab specimens using field-effect transistor-based biosensor, ACS Nano, 14, 5135, 10.1021/acsnano.0c02823 Wu, 2020, Dual-aptamer modified graphene field-effect transistor nanosensor for label-free and specific detection of hepatocellular carcinoma-derived microvesicles, Anal. Chem., 92, 4006, 10.1021/acs.analchem.9b05531 Hao, 2021, An intelligent graphene-based biosensing device for cytokine storm syndrome biomarkers detection in human biofluids, Small, 17, 1, 10.1002/smll.202101508 Li, 2019, Selective detection of water pollutants using a differential aptamer-based graphene biosensor, Biosens. Bioelectron., 126, 59, 10.1016/j.bios.2018.10.047 Ke, 2021, An accurate, high-speed, portable bifunctional electrical detector for COVID-19, Sci. China Mater., 64, 739, 10.1007/s40843-020-1577-y Zhao, 2014, Photoelectrochemical bioanalysis: a mini review, Electrochem. Commun., 38, 40, 10.1016/j.elecom.2013.10.035 Xue, 2019, Antimony selenide/graphene oxide composite for sensitive photoelectrochemical detection of DNA methyltransferase activity, J. Mater. Chem. B., 7, 6789, 10.1039/C9TB01541H Meng, 2020, A novel signal-off photoelectrochemical biosensor for M.SssI MTase activity assay based on GQDs@ZIF-8 polyhedra as signal quencher, Biosens. Bioelectron., 150, 111861, 10.1016/j.bios.2019.111861 Amouzadeh Tabrizi, 2021, A photo-electrochemical aptasensor for the determination of severe acute respiratory syndrome coronavirus 2 receptor-binding domain by using graphitic carbon nitride-cadmium sulfide quantum dots nanocomposite, Sensor. Actuator. B Chem., 345, 130377, 10.1016/j.snb.2021.130377 Li, 2017, Using p-type PbS quantum dots to quench photocurrent of fullerene-Au NP@MoS2 composite structure for ultrasensitive photoelectrochemical detection of ATP, ACS Appl. Mater. Interfaces, 9, 42111, 10.1021/acsami.7b13894 Wang, 2018, An ultrasensitive photoelectrochemical biosensor based on [Ru(dcbpy)2dppz]2+/Rose Bengal dyes co-sensitized fullerene for DNA detection, Biosens. Bioelectron., 120, 71, 10.1016/j.bios.2018.08.035 Long, 2019, A photoelectrochemical biosensor based on fullerene with methylene blue as a sensitizer for ultrasensitive DNA detection, Biosens. Bioelectron., 142, 111579, 10.1016/j.bios.2019.111579 Wang, 2019, p-n-sensitized heterostructure Co3O4/Fullerene with highly efficient photoelectrochemical performance for ultrasensitive DNA detection, ACS Appl. Mater. Interfaces, 11, 23765, 10.1021/acsami.9b05923 Wang, 2021, Fullerenol as a photoelectrochemical nanoprobe for discrimination and ultrasensitive detection of amplification-free single-stranded DNA, Biosens. Bioelectron., 173, 112802, 10.1016/j.bios.2020.112802 Wang, 2019, Sensitivity enhancement of cloth-based closed bipolar electrochemiluminescence glucose sensor via electrode decoration with chitosan/multi-walled carbon nanotubes/graphene quantum dots-gold nanoparticles, Biosens. Bioelectron., 130, 55, 10.1016/j.bios.2019.01.027 Bahari, 2020, A self-enhanced ECL-RET immunosensor for the detection of CA19-9 antigen based on Ru(bpy)2(phen-NH2)2+- Amine-rich nitrogen-doped carbon nanodots as probe and graphene oxide grafted hyperbranched aromatic polyamide as platform, Anal. Chim. Acta, 1132, 55, 10.1016/j.aca.2020.07.023 Wang, 2018, A sandwich-type electrochemiluminescence aptasensor for insulin detection based on the nano-C60/BSA@luminol nanocomposite and ferrocene derivative, Electrochim. Acta, 290, 90, 10.1016/j.electacta.2018.08.080 Yang, 2020, Ultrasensitive “signal-on” electrochemiluminescence immunosensor for prostate-specific antigen detection based on novel nanoprobe and poly(indole-6-carboxylic acid)/flower-like Au nanocomposite, Sensor. Actuator. B Chem., 303, 127246, 10.1016/j.snb.2019.127246 Qin, 2020, Electrochemiluminescence immunoassay of human chorionic gonadotropin using silver carbon quantum dots and functionalized polymer nanospheres, Microchim. Acta, 187, 482, 10.1007/s00604-020-04450-0 Iizumi, 2013, Immunoassay with single-walled carbon nanotubes as near-infrared fluorescent labels, ACS Appl. Mater. Interfaces, 5, 7665, 10.1021/am401702q Chinnappan, 2020, Aptameric biosensor for the sensitive detection of major shrimp allergen, tropomyosin, Food Chem., 314, 126113, 10.1016/j.foodchem.2019.126133 Xia, 2017, A visible and colorimetric aptasensor based on DNA-capped single-walled carbon nanotubes for detection of exosomes, Biosens. Bioelectron., 92, 8, 10.1016/j.bios.2017.01.063 Li, 2019, POMOF/SWNT nanocomposites with prominent peroxidase-mimicking activity for L-Cysteine “on-off switch” colorimetric biosensing, ACS Appl. Mater. Interfaces, 11, 16896, 10.1021/acsami.9b00872 Wang, 2018, Colorimetric determination of glutathione by using a nanohybrid composed of manganese dioxide and carbon dots, Microchim. Acta, 185, 291, 10.1007/s00604-018-2830-6 Bai, 2020, Ultrasensitive colorimetric biosensor for BRCA1 mutation based on multiple signal amplification strategy, Biosens. Bioelectron., 166, 112424, 10.1016/j.bios.2020.112424 Gupta, 2021, Naked eye colorimetric detection of Escherichia coli using aptamer conjugated graphene oxide enclosed Gold nanoparticles, Sensor. Actuator. B Chem., 329, 129100, 10.1016/j.snb.2020.129100 Wei, 2019, Multicolor and photothermal dual-readout biosensor for visual detection of prostate specific antigen, Biosens. Bioelectron., 140, 111345, 10.1016/j.bios.2019.111345 Jia, 2017, An immunochromatographic assay for carcinoembryonic antigen on cotton thread using a composite of carbon nanotubes and gold nanoparticles as reporters, Anal. Chim. Acta, 969, 57, 10.1016/j.aca.2017.02.040 Meng, 2017, Novel immunochromatographic assay on cotton thread based on carbon nanotubes reporter probe, Talanta, 167, 379, 10.1016/j.talanta.2017.02.023 Huang, 2017, Magnetized carbon nanotubes for visual detection of proteins directly in whole blood, Anal. Chim. Acta, 993, 79, 10.1016/j.aca.2017.09.025 Morales-Narváez, 2012, Graphene oxide as an optical biosensing platform, Adv. Mater., 24, 3298, 10.1002/adma.201200373 Bozkurt, 2014, Rhodamine 101-graphene oxide composites in aqueous solution: the fluorescence quenching process of rhodamine 101, Phys. Chem. Chem. Phys., 16, 18276, 10.1039/C4CP01492H Sun, 2017, Fluorescent carbon dots and their sensing applications, TrAC Trends Anal. Chem. (Reference Ed.), 89, 163, 10.1016/j.trac.2017.02.001 Xiang, 2020, Highly sensitive detection of carcinoembryonic antigen using copper-free click chemistry on the surface of azide cofunctionalized graphene oxide, Anal. Chim. Acta, 1127, 156, 10.1016/j.aca.2020.06.053 Avila-Huerta, 2021, Facile determination of COVID-19 seroconversion via nonradiative energy transfer, ACS Sens., 6, 2136, 10.1021/acssensors.1c00795 Liu, 2018, Quantum dot fullerene-based molecular beacon nanosensors for rapid, highly sensitive nucleic acid detection, ACS Appl. Mater. Interfaces, 10, 18524, 10.1021/acsami.8b03552 Liu, 2020, Ribonuclease H enzyme activity detection based on hybridization chain reaction amplification and graphene oxide nanosheets fluorescence quenching, J. Nanosci. Nanotechnol., 20, 1409, 10.1166/jnn.2020.17351 Wang, 2021, Ultrasensitive, high-throughput, and rapid simultaneous detection of SARS-CoV-2 antigens and IgG/IgM antibodies within 10 min through an immunoassay biochip, Microchim. Acta, 188, 262, 10.1007/s00604-021-04896-w Achadu, 2020, Plasmonic/magnetic molybdenum trioxide and graphitic carbon nitride quantum dots-based fluoroimmunosensing system for influenza virus, Sensor. Actuator. B Chem., 321, 128494, 10.1016/j.snb.2020.128494 Xu, 2021, Immunoassay of SARS-CoV-2 nucleocapsid proteins using novel red emission-enhanced carbon dot-based silica spheres, Analyst, 146, 5055, 10.1039/D1AN01010G Khalil, 2016, Graphene-gold nanoparticles hybrid-synthesis, functionalization, and application in a electrochemical and surface-enhanced Raman scattering biosensor, Materials, 9, 406, 10.3390/ma9060406 Soda, 2019, Advanced liquid biopsy technologies for circulating biomarker detection, J. Mater. Chem. B., 7, 6670, 10.1039/C9TB01490J El-Said, 2022, Synthesis of gold nanoparticles@reduced porous graphene-modified ITO electrode for spectroelectrochemical detection of SARS-CoV-2 spike protein, Spectrochim. Acta Part A Mol. Biomol. Spectrosc., 264, 120237, 10.1016/j.saa.2021.120237 Pan, 2019, A graphene oxide-gold nanostar hybrid based-paper biosensor for label-free SERS detection of serum bilirubin for diagnosis of jaundice, Biosens. Bioelectron., 145, 111713, 10.1016/j.bios.2019.111713 Li, 2019, Graphene oxide-assisted and DNA-modulated SERS of AuCu alloy for the fabrication of apurinic/apyrimidinic endonuclease 1 biosensor, Small, 15, 1901506, 10.1002/smll.201901506 Lin, 2016, Graphene-based nanomaterials for bioimaging, Adv. Drug Deliv. Rev., 105, 242, 10.1016/j.addr.2016.05.013 Xu, 2017, Preparation, photoluminescence properties and application for in vivo tumor imaging of curcumin derivative-functionalized graphene oxide composite, Dyes Pigments, 141, 470, 10.1016/j.dyepig.2017.02.046 Yan, 2015, Enhanced fluorescence imaging guided photodynamic therapy of sinoporphyrin sodium loaded graphene oxide, Biomaterials, 42, 94, 10.1016/j.biomaterials.2014.11.040 Lyu, 2020, Facile, gram-scale and eco-friendly synthesis of multi-color graphene quantum dots by thermal-driven advanced oxidation process, Chem. Eng. J., 388, 124285, 10.1016/j.cej.2020.124285 Fu, 2020, Polyethylene Glycol6000/carbon nanodots as fluorescent bioimaging agents, Nanomaterials, 10, 677, 10.3390/nano10040677 Yudasaka, 2018, Fasting-dependent vascular permeability enhancement in brown adipose tissues evidenced by using carbon nanotubes as fluorescent probes, Sci. Rep., 8, 14446, 10.1038/s41598-018-32758-8 Diao, 2015, Fluorescence imaging in vivo at wavelengths beyond 1500 nm, Angew. Chem. Int. Ed., 54, 14758, 10.1002/anie.201507473 Yoo, 2015, Graphene-based nanomaterials for versatile imaging studies, Chem. Soc. Rev., 44, 4835, 10.1039/C5CS00072F Kuo, 2020, Amino-functionalized nitrogen-doped graphene-quantum-dot-based nanomaterials with nitrogen and amino-functionalized group content dependence for highly efficient two-photon bioimaging, Int. J. Mol. Sci., 21, 10.3390/ijms21082939 Luo, 2018, Graphene quantum dots modified with adenine for efficient two-photon bioimaging and white light-activated antibacteria, Appl. Surf. Sci., 434, 155, 10.1016/j.apsusc.2017.10.121 Qin, 2019, Nanoconjugates of Ag/Au/Carbon nanotube for alkyne-meditated ratiometric SERS imaging of hypoxia in hepatic ischemia, Anal. Chem., 91, 4529, 10.1021/acs.analchem.8b05487 Bugárová, 2020, Molecular targeting of bioconjugated graphene oxide nanocarriers revealed at a cellular level using label-free Raman imaging, Nanomed. Nanotechnol. Biol. Med., 30, 102280, 10.1016/j.nano.2020.102280 Enzinger, 2015, Nonconventional MRI and microstructural cerebral changes in multiple sclerosis, Nat. Rev. Neurol., 11, 676, 10.1038/nrneurol.2015.194 Yan, 2017, Single-walled carbon nanotube-loaded doxorubicin and Gd-DTPA for targeted drug delivery and magnetic resonance imaging, J. Drug Target., 25, 163, 10.1080/1061186X.2016.1221958 Moghaddam, 2018, A new high-performance gadonanotube-polymer hybrid material for stem cell labeling and tracking by MRI, Contrast Media Mol. Imaging, 1, 10.1155/2018/2853736 Wang, 2020, Single-layer boron-doped graphene quantum dots for contrast-enhanced: in vivo T1-weighted MRI, Nanoscale Horiz, 5, 573, 10.1039/C9NH00608G Peng, 2019, Activatable core-shell metallofullerene: an efficient nanoplatform for bimodal sensing of glutathione, ACS Appl. Mater. Interfaces, 11, 46637, 10.1021/acsami.9b18807 Chen, 2018, Laser-assisted in situ synthesis of graphene-based magnetic-responsive hybrids for multimodal imaging-guided chemo/photothermal synergistic therapy, Talanta, 182, 433, 10.1016/j.talanta.2018.02.030 Zhang, 2018, Near-infrared light-mediated photodynamic/photothermal therapy nanoplatform by the assembly of Fe3O4 carbon dots with graphitic black phosphorus quantum dots, Int. J. Nanomed., 13, 2803, 10.2147/IJN.S156434 Ge, 2017, Behavior of supramolecular assemblies of radiometal-filled and fluorescent carbon nanocapsules in vitro and in vivo, Inside Chem., 3, 437 Peng, 2017, Positron emission tomography (PET) guided glioblastoma targeting by a fullerene-based nanoplatform with fast renal clearance, Acta Biomater., 61, 193, 10.1016/j.actbio.2017.08.011 Cao, 2017, Chelator-free conjugation of 99mTc and Gd3+ to PEGylated nanographene oxide for dual-modality SPECT/MR imaging of lymph nodes, ACS Appl. Mater. Interfaces, 9, 42612, 10.1021/acsami.7b14836 Attia, 2019, A review of clinical photoacoustic imaging: current and future trends, Photoacoustics, 16, 100144, 10.1016/j.pacs.2019.100144 Nie, 2014, Structural and functional photoacoustic molecular tomography aided by emerging contrast agents, Chem. Soc. Rev., 43, 7132, 10.1039/C4CS00086B la Zerda, 2010, Ultrahigh sensitivity carbon nanotube agents for photoacoustic molecular imaging in living mice, Nano Lett., 10, 2168, 10.1021/nl100890d Genady, 2020, 99mTc-functionalized single-walled carbon nanotubes for bone targeting, ACS Appl. Mater. Interfaces, 3, 11819, 10.1021/acsanm.0c02339 Chen, 2014, Core-shell Pd@Au nanoplates as theranostic agents for in-vivo photoacoustic imaging, CT imaging, and photothermal therapy, Adv. Mater., 26, 8210, 10.1002/adma.201404013 Xuan, 2019, Ultrafast synthesis of gold nanosphere cluster coated by graphene quantum dot for active targeting PA/CT imaging and near-infrared laser/pH-triggered chemo-photothermal synergistic tumor therapy, Chem. Eng. J., 369, 87, 10.1016/j.cej.2019.03.035 Wang, 2017, Highly sensitive and multiplexed quantification of mRNA splice variants by the direct ligation of DNA probes at the exon junction and universal PCR amplification, Chem. Sci., 8, 3635, 10.1039/C7SC00094D Deng, 2015, Bioanalytical applications of isothermal nucleic acid amplification techniques, Anal. Chim. Acta, 853, 30, 10.1016/j.aca.2014.09.037 Liu, 2013, Graphene oxide/nucleic-acid-stabilized silver nanoclusters: functional hybrid materials for optical aptamer sensing and multiplexed analysis of pathogenic DNAs, J. Am. Chem. Soc., 135, 11832, 10.1021/ja403485r Jeong, 2021, Extraction of viral nucleic acids with carbon nanotubes increases SARS-CoV-2 quantitative reverse transcription polymerase chain reaction detection sensitivity, ACS Nano, 15, 10309, 10.1021/acsnano.1c02494 Wang, 2017, Graphene oxide enhances the specificity of the polymerase chain reaction by modifying primer-template matching, Sci. Rep., 7 Hu, 2020, A strategy for preparing non-fluorescent graphene oxide quantum dots as fluorescence quenchers in quantitative real-time PCR, RSC Adv., 10, 10.1039/D0RA00142B Hu, 2021, Graphene oxide-based qRT-PCR assay enables the sensitive and specific detection of miRNAs for the screening of ovarian cancer, Anal. Chim. Acta, 1174, 338715, 10.1016/j.aca.2021.338715 Kim, 2020, Effects of graphene oxide-gold nanoparticles nanocomposite on highly sensitive foot-and-mouth disease virus detection, Nanomaterials, 10, 1, 10.3390/nano10101921 Li, 2005, Nanoparticle PCR: nanogold-assisted PCR with enhanced specificity, Angew. Chem. Int. Ed., 44, 5100, 10.1002/anie.200500403 Wu, 2012, Size-dependent interactions between Au Nanoparticles and DNA in electrochemical oxidation by metal complexes, J. Phys. Chem. C, 116, 8020, 10.1021/jp209470g Jung, 2017, Extensible multiplex real-time PCR for rapid bacterial identification with carbon nanotube composite microparticles, Biosens. Bioelectron., 94, 256, 10.1016/j.bios.2017.02.049 Cai, 2021, Self-assembled DNA nanoflowers triggered by a DNA walker for highly sensitive electrochemical detection of Staphylococcus aureus, ACS Appl. Mater. Interfaces, 13, 4905, 10.1021/acsami.0c22062 Wang, 2018, ATP mediated rolling circle amplification and opening DNA-gate for drug delivery to cell, Talanta, 176, 652, 10.1016/j.talanta.2017.08.087 Lin, 2019, Graphene oxide-based suppression of nonspecificity in loop-mediated isothermal amplification enabling the sensitive detection of cyclooxygenase-2 mRNA in colorectal cancer, Anal. Chem., 91, 15694, 10.1021/acs.analchem.9b03861 Choi, 2021, Combined recombinase polymerase amplification/rkDNA–graphene oxide probing system for detection of SARS-CoV-2, Anal. Chim. Acta, 1158, 338390, 10.1016/j.aca.2021.338390 Giannetto, 2017, Competitive amperometric immunosensor for determination of p53 protein in urine with carbon nanotubes/gold nanoparticles screen-printed electrodes: a potential rapid and noninvasive screening tool for early diagnosis of urinary tract carcinoma, Anal. Chim. Acta, 991, 133, 10.1016/j.aca.2017.09.005 Marcano, 2010, Improved synthesis of graphene oxide, ACS Nano, 4, 4806, 10.1021/nn1006368 Kim, 2020, Clinically accurate diagnosis of Alzheimer's disease via multiplexed sensing of core biomarkers in human plasma, Nat. Commun., 11, 1 Yang, 2019, Biodegradation of carbon nanotubes by macrophages, Front. Mater., 6, 10.3389/fmats.2019.00225 Chen, 2017, Biodegradation of carbon nanotubes, graphene, and their derivatives, Trends Biotechnol., 35, 836, 10.1016/j.tibtech.2016.12.001 Ma, 2020, Degradation-by-design: how chemical functionalization enhances the biodegradability and safety of 2D materials, Chem. Soc. Rev., 49, 6224, 10.1039/C9CS00822E Kurapati, 2015, Dispersibility-dependent biodegradation of graphene oxide by myeloperoxidase, Small, 11, 3985, 10.1002/smll.201500038