Băng gạc hydrogel bắt chước đa chức năng cung cấp điều trị kháng nhiễm và cải thiện liệu pháp miễn dịch bằng cách tái lập trình môi trường vi mô vết thương liên quan đến nhiễm trùng
Tóm tắt
Sự phát triển của các vật liệu sinh học có tính chất chống vi khuẩn và khả năng chữa lành vết thương tiếp tục đặt ra những thách thức. Đại thực bào được công nhận vì vai trò quan trọng của chúng trong việc sửa chữa vết thương liên quan đến nhiễm trùng. Tuy nhiên, sự tương tác giữa vật liệu sinh học và đại thực bào vẫn còn phức tạp và cần được nghiên cứu thêm. Trong nghiên cứu này, chúng tôi đề xuất một phương pháp điều biến miễn dịch theo trình tự mới nhằm tăng cường và đẩy nhanh quá trình chữa lành vết thương bằng cách tận dụng các đặc tính miễn dịch của vết thương liên quan đến vi khuẩn, sử dụng một loại băng gạc hydrogel hỗn hợp mới. Ma trận hydrogel được chiết xuất từ ma trận da không tế bào lợn (PADM) và được nạp với một loại hạt nano thủy tinh sinh học mới (MBG) có doping magie (Mg-MBG) và có chứa Curcumin (Cur). Hydrogel lai này cho thấy sự phóng thích có kiểm soát của Cur, hiệu quả trong việc tiêu diệt nhiễm khuẩn trong giai đoạn đầu của nhiễm trùng vết thương, và sự phóng thích tiếp theo của các ion Mg (Mg2+) có tác dụng hiệp đồng trong việc ức chế sự kích hoạt của các con đường liên quan đến viêm (như con đường MAPK, con đường NF-κB, con đường TNF-α, v.v.), ức chế phản ứng viêm gây ra bởi nhiễm trùng. Do đó, hydrogel đổi mới này có thể nhanh chóng và hiệu quả đẩy nhanh quá trình chữa lành vết thương trong thời gian bị nhiễm trùng. Chiến lược thiết kế của chúng tôi khám phá các vật liệu sinh học điều biến miễn dịch mới, cung cấp một cách tiếp cận mới để giải quyết những thách thức lâm sàng hiện tại liên quan đến điều trị nhiễm trùng vết thương.
Từ khóa
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