Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo

Immunity - Tập 53 - Trang 548-563.e8 - 2020
Yu Kato1,2, Robert K. Abbott1,2, Brian L. Freeman1, Sonya Haupt1,3, Bettina Groschel2,4,5, Murillo Silva2,6, Sergey Menis2,4,5, Darrell J. Irvine2,6,7,8,9,10, William R. Schief2,4,5,9, Shane Crotty1,2,3
1Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA 92037, USA
2Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD), La Jolla, CA 92037, USA
3Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA 92037, USA
4Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA
5IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA
6Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
7Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139 USA
8Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
9The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA
10Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA

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