Đánh giá đa trung tâm về gemcitabine–carboplatin trong điều trị neoadjuvant và induction so với gemcitabine–cisplatin sau phẫu thuật cắt bàng quang triệt để cho u bàng quang xâm lấn cơ

Springer Science and Business Media LLC - Tập 40 - Trang 2707-2715 - 2022
Sarah M. H. Einerhand1, Anna J. Black2, Homayoun Zargar3, Adrian S. Fairey4,5, Colin P. Dinney6, Maria C. Mir7, Laura-Maria Krabbe8, Michael S. Cookson9, Niels-Erik Jacobson5, Jeffrey S. Montgomery10, Nikhil Vasdev11,12, Evan Y. Yu13, Evanguelos Xylinas14, Wassim Kassouf15, Marc A. Dall’Era16, Srikala S. Sridhar17, Jonathan S. McGrath18, Jonathan Aning12,18, Shahrokh F. Shariat14,19, Jonathan L. Wright13, Andrew C. Thorpe12, Todd M. Morgan10, Jeff M. Holzbeierlein20, Trinity J. Bivalacqua21, Scott North22, Daniel A. Barocas23, Yair Lotan24, Petros Grivas13, Jorge A. Garcia25, Andrew J. Stephenson26, Jay B. Shah27, Siamak Daneshmand4, Kamran Zargar-Shoshtari28, Philippe E. Spiess28, Bas W. G. van Rhijn1,29, Peter C. Black2, Laura S. Mertens1
1Department of Surgical Oncology (Urology), The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
2Vancouver Prostate Centre, Vancouver, Canada
3Department of Urology, Western Health, Melbourne, Australia
4USC/Norris Comprehensive Cancer Center, Institute of Urology, University of Southern California, Los Angeles, USA
5University of Alberta, Edmonton, Canada
6Department of Urology, MD Anderson Cancer Center, Houston, USA
7Department of Urology, Fundacion Instituto Valenciano de Oncologia, Valencia, Spain
8Department of Urology, University of Münster, Münster, Germany
9Department of Urology, University of Oklahoma College of Medicine, Oklahoma City, USA
10Department of Urology, University of Michigan Health System, Ann Arbor, USA
11Hertfordshire and Bedfordshire Urological Cancer Centre, Department of Urology, Lister Hospital, Stevenage, UK
12Department of Urology, Freeman Hospital, Newcastle Upon Tyne, UK
13Division of Oncology, Department of Medicine, University of Washington School of Medicine and Fred Hutchinson Cancer Center, Seattle, USA
14Department of Urology, Weill Cornell Medical College, Presbyterian Hospital New York, New York, USA
15Department of Surgery (Division of Urology), McGill University Health Centre, Montreal, Canada
16Department of Urology, David Medical Center, University of California at David, Sacramento, USA
17Princess Margaret Hospital, Toronto, Canada
18Department of Surgery, Exeter Surgical Health Services Research Unit, Royal Devon and Exeter NHS Trust, Exeter, UK
19Department of Urology, Vienna General Hospital, Medical University of Vienna, Vienna, Austria
20Department of Urology, University of Kansas Medical Center, Kansas City, USA
21Division of Urology, University of Pennsylvania, Pennsylvania, USA
22Cross Cancer Institute, Edmonton, Canada
23Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, USA
24Department of Urology, University of Texas Southern Medical Center, Dallas, USA
25Department of Medicine, Case Comprehensive Cancer Center, Cleveland, USA
26Division of Urology, Rush University Medical Center, Chicago, USA
27Department of Urology, Stanford University School of Medicine, Stanford, USA
28Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, USA
29Department of Urology, Caritas St. Josef Medical Center, University of Regensburg, Regensburg, Germany

Tóm tắt

Hóa trị liệu dựa trên cisplatin tiếp theo là cắt bàng quang triệt để (RC) được khuyến nghị cho bệnh nhân mắc ung thư bàng quang xâm lấn cơ (MIBC). Tuy nhiên, có đến 50% bệnh nhân không đủ điều kiện dùng cisplatin. Mục tiêu của nghiên cứu này là so sánh kết quả lâm sàng sau ≥ 3 chu kỳ gemcitabine–carboplatin (gem–carbo) trước phẫu thuật so với gemcitabine–cisplatin (gem–cis). Chúng tôi đã xác định 1865 bệnh nhân được điều trị tại 19 trung tâm trong khoảng thời gian từ 2000 đến 2013. Bệnh nhân được đưa vào nghiên cứu nếu họ đã nhận ≥ 3 chu kỳ gem–carbo (cT2-4aN0M0) hoặc gem–cis (cTanyN + M0) trước phẫu thuật RC. Chúng tôi đã đưa vào phân tích 747 bệnh nhân được điều trị bằng gem–carbo (n = 147) hoặc gem–cis (n = 600). Bệnh nhân được điều trị bằng gem–carbo có chỉ số comorbidity Charlson cao hơn (p = 0,016) và có nhiều bệnh lý hạch lâm sàng dương tính hơn (32% so với 20%; p = 0,013). Tỷ lệ phản ứng bệnh lý hoàn toàn (pCR; ypT0N0) không có sự khác biệt đáng kể giữa gem–carbo và gem–cis (20,7% so với 22,1%; p = 0,73). Chế độ hóa trị không có mối liên hệ đáng kể với pCR (OR 0,99 [95%CI 0,61–1,59]; p = 0,96), tỷ lệ sống toàn bộ (OS) (HR 1,20 [95%CI 0,85–1,67]; p = 0,31) hoặc tỷ lệ sống sót đặc hiệu với ung thư (CSS) (HR 1,35 [95%CI 0,93–1,96]; p = 0,11). Thời gian sống trung vị của bệnh nhân được điều trị bằng gem–carbo và gem–cis lần lượt là 28,6 tháng (95%CI 18,1–39,1) và 45,1 tháng (95%CI 32,7–57,6) (p = 0,18). Thời gian sống sót trung vị của bệnh nhân được điều trị bằng gem–carbo và gem–cis lần lượt là 28,8 tháng (95%CI 9,8–47,8) và 71,0 tháng (95%CI chưa đạt được) (p = 0,02). Các phân tích phụ của cài đặt neoadjuvant và induction không cho thấy sự khác biệt sống sót đáng kể. Kết quả của chúng tôi cho thấy một nhóm bệnh nhân không đủ điều kiện dùng cisplatin với MIBC đạt pCR khi dùng gem–carbo và rằng kết quả sống sót dường như tương đương với gem–cis nếu bệnh nhân có thể nhận ≥ 3 chu kỳ và trải qua RC.

Từ khóa

#ung thư bàng quang #hóa trị liệu #cisplatin #gemcitabine #cắt bàng quang triệt để #pCR #sống sót toàn bộ #sống sót đặc hiệu với ung thư

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