Cơ chế điều tiết đa mục tiêu của Yang Xin Tang - một loại thuốc truyền thống Trung Quốc chống lại chứng mất trí nhớ
Tóm tắt
Từ khóa
Tài liệu tham khảo
Briggs R, Kennelly SP, O’Neill D. Drug treatments in Alzheimer’s disease. Clin Med. 2016;16(3):247–53.
Breijyeh Z, Karaman R. Comprehensive review on Alzheimer’s disease: causes and treatment. Molecules. 2020;25(24):5789.
van Bokhoven P, de Wilde A, Vermunt L, Leferink PS, Heetveld S, Cummings J, Scheltens P, Vijverberg EGB. The Alzheimer’s disease drug development landscape. Alzheimer’s Res Ther. 2021;13:186.
Chen SY, Gao Y, Sun JY, Meng XL, Yang D, Fan LH, Li X, Wang P. Traditional Chinese medicine: role in reducing β-Amyloid, apoptosis, autophagy, neuroinflammation, oxidative stress, and mitochondrial dysfunction of Alzheimer’s disease. Front Pharmacol. 2020;11:497.
Chen X, Drew J, Berney W, Lei W. Neuroprotective natural products for Alzheimer’s disease. Cells. 2021;10(6):1309.
Jiao Y, Kong L, Yao Y, Li S, Tao Z, Yang J. Osthole decreases β-amyloid levels through up-regulation of miR-107 in Alzheimer’s disease. Neuropharmacol. 2016;108:332–44.
Zeng P, Shi Y, Wang XM, Lin L, Du YJ, Tang N. Emodin rescued hyperhomocysteinemia-induced dementia and Alzheimer’s disease-like features in rats. Int J Neuropsychopharmacol. 2019;22(1):57–70.
Kandiah N, Ong PA, Yuda T, Ng L, Mamun K, Merchant RA, Chen C, Dominguez J, Marasigan S, Ampil E, Nguyen VT, Yusoff S, Chan YF, Yong FM, Krairit O, Suthisisang C, Senanarong V, Ji Y, Thukral R, Ihl R. Treatment of dementia and mild cognitive impairment with or without cerebrovascular disease: expert consensus on the use of ginkgo biloba extract, EGb 761®. CNS Neurosci Ther. 2019. https://doi.org/10.1111/cns.13095.
Xiao S, Chan P, Wang T, Hong Z, Wang S, Kuang W, He J, Pan X, Zhou Y, Ji Y, Wang L, Cheng Y, Peng Y, Ye Q, Wang X, Wu Y, Qu Q, Chen S, Li S, Chen W, Xu J, Peng D, Zhao Z, Li Y, Zhang J, Du Y, Chen W, Fan D, Yan Y, Liu X, Zhang W, Luo B, Wu W, Shen L, Liu C, Mao P, Wang Q, Zhao Q, Guo Q, Zhou Y, Li Y, Jiang L, Ren W, Ouyang Y, Wang Y, Liu S, Jia J, Zhang N, Liu Z, He R, Feng T, Lu W, Tang H, Gao P, Zhang Y, Chen L, Wang L, Yin Y, Xu Q, Xiao J, Cong L, Cheng X, Zhang H, Gao D, Xia M, Lian T, Peng G, Zhang X, Jiao B, Hu H, Chen X, Guan Y, Cui R, Huang Q, Xin X, Chen H, Ding Y, Zhang J, Feng T, Cantillon M, Chen K, Cummings JL, Ding J, Geng M, Zhang Z. A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer’s dementia. Alzheimer’s Res Ther. 2021;13(1):62.
Gu SC, Shi R, Gaoag C, Yuan XL, Wu Y, Zhang Y, De Wang C, Fan RD, Chen X, Yuan CX, Ye Q. Traditional Chinese medicine Pingchan granule for motor symptoms and functions in Parkinson’s disease: a multicenter, randomized, double-blind, placebo-controlled study. Phytomedicine. 2023;108:154497.
Lin Z, Gu J, Xiu J, Mi T, Dong J, Tiwari JK. Traditional Chinese medicine for senile dementia. Evid-Based Complementary Altern Med. 2012. https://doi.org/10.1155/2012/692621.
Wang L, Yan J, Wang X, Wu F, Liu X, Huang Y, Liu M, Ma X, Wang Q. Pattern characteristics of Yangxin decoction and application combined with other prescriptions. Modern Chinese Clinical Medicine 2018;25(5).
Zhu W, Hu H. A survey of TCM treatment for Alzheimer’s disease. J Tradit Chin Med. 2007;27(3):226–32.
Li WZ, Wu WY, Huang DK, Yin YY, Kan HW, Wang X, Yao YY, Li WP. Protective effects of astragalosides on dexamethasone and Aβ25-35 induced learning and memory impairments due to decrease amyloid precursor protein expression in 12-month male rats. Food Chem Toxicol. 2012;50(6):1883–90.
Ikeya Y, Takeda S, Tunakawa M, Karakida H, Toda K, Yamaguchi T, Aburada M. Cognitive improving and cerebral protective effects of acylated oligosaccharides in polygala tenuifolia. Biol Pharm Bull. 2004;27(7):1081–5.
Park HJ, Lee K, Heo H, Lee M, Kim JW, Whang WW, Kwon YK, Kwon H. Effects of polygala tenuifolia root extract on proliferation of neural stem cells in the hippocampal CA1 region. Phytother Res. 2008;22(10):1324–9.
Liu AMF, Wong YH. G16-mediated activation of nuclear factor κB by the adenosine A1 receptor involves c-Src, protein kinase C, and ERK signaling. J Biol Chem. 2004;279:53196–204.
Chan AS, Pang H, Yip ECH, Tam YK, Wong YH. The aqueous extract of Radix Glycyrrhizae stimulates mitogen-activated protein kinases and nuclear factor-κB in Jurkat T-cells and monocytic THP-1 cells. Am J Chin Med. 2006;34(2):263–78.
Ellman GL, Courteny KD, Andres V Jr, Feather-Stone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol. 1961;7:88–95.
Hügel HM, Jackson N, May BH, Xue CC. Chinese herbs for dementia diseases. Mini Rev Med Chem. 2012;12(5):371–9.
Ran X, Ma L, Peng C, Zhang H, Qin LP. Ligusticum chuanxiong Hort: a review of chemistry and pharmacology. Pharm Biol. 2011;49(11):1180–9.
Lemkul JA, Bevan DR. Morin inhibits the early stages of amyloid β-peptide aggregation by altering tertiary and quaternary interactions to produce “off-pathway” structures. Biochemistry. 2012;51(30):5990–6009.
Deschênes-Furry J, Bélanger G, Perrone-Bizzozero N, Jasmin BJ. Post-transcriptional regulation of acetylcholinesterase mRNAs in nerve growth factor PC12 cells by the RNA-binding protein HuD. J Biol Chem. 2003;278(8):5710–7.
Choi SH, Kim YH, Hebisch M, Sliwinski C, Lee S, D’Avanzo C, Chen H, Hooli B, Asselin C, Muffat J, Klee JB, Zhang C, Wainger BJ, Peitz M, Kovacs DM, Woolf CJ, Wagner SL, Tanzi RE, Kim DY. A three-dimensional human neural cell culture model of Alzheimer’s disease. Nature. 2014;515:274–8.
Schimmelpfeng J, Weibezahn KF, Dertinger H. Quantification of NGF-dependent neuronal differentiation of PC-12 cells by means of neurofilament-L mRNA expression and neuronal outgrowth. J Neurosci Methods. 2004;139(2):299–306.
Wang R, Reddy PH. Role of glutamate and NMDA receptors in Alzheimer’s disease. J Alzheimer’s Dis. 2017;57(4):1041–8.
Sung S, Yang H, Uryu K, Lee EB, Zhao L, Shineman D, Trojanowski JQ, Lee VMY, Praticò D. Modulation of nuclear factor-κB activity by indomethacin influences Aβ levels but not Aβ precursor protein metabolism in a model of Alzheimer’s disease. Am J Pathol. 2004;165:2197–206.
Temp FR, Marafiga JR, Milanesi LH, Duarte T, Rambo LM, Pillat MM, Mello CF. Cyclooxygenase-2 inhibitors differentially attenuate pentylenetetrazol-induced seizures and increase of pro- and anti-inflammatory cytokines levels in the cerebral cortex and hippocampus of mice. Eur J Pharmacol. 2017;810:15–25.
Tao X, Finkbeiner S, Arnold DB, Shaywitz AJ, Greenberg ME. Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism. Neuron. 1998;20(4):709–26.
Reichenbach N, Delekate A, Plescher M, Schmitt F, Krauss S, Blank N, Halle A, Petzold GC. Inhibition of Stat3-mediated astrogliosis ameliorates pathology in an Alzheimer’s disease model. EMBO Mol Med. 2019;11(2):e9665.
Gu F, Hata R, Ma YJ, Tanaka J, Mitsuda N, Kumon Y, Hanakawa Y, Hashimoto K, Nakajima K, Sakanaka M. Suppression of Stat3 promotes neurogenesis in cultured neural stem cells. J Neurosci Res. 2005;81(2):163–71.
Rossi S, Motta C, Studer V, Macchiarulo G, Volpe E, Barbieri F, Ruocco G, Buttari F, Finardi A, Mancino R, Weiss S, Battistini L, Martino G, Furlan R, Drulovic J, Centonze D. Interleukin-1β causes excitotoxic neurodegeneration and multiple sclerosis disease progression by activating the apoptotic protein p53. Mol Neurodegener. 2014;9:56.
Shen J, Xu S, Zhou H, Liu H, Jiang W, Hao J, Hu Z. IL-1β induces apoptosis and autophagy via mitochondria pathway in human degenerative nucleus pulposus cells. Sci Rep. 2017;7:41067.
Tominaga K, Suzuki HI. TGF-β signaling in cellular senescence and aging-related pathology. Int J Mol Sci. 2019;20(20):5002.
von Bernhardi R, Cornejo F, Parada GE, Eugenín J. Role of TGFβ signaling in the pathogenesis of Alzheimer’s disease. Front Cell Neurosci. 2015;9:426.
Wouk J, Rechenchoski DZ, Rodrigues B, Ribelato EV, Faccin-Galhardi LC. Viral infections and their relationship to neurological disorders. Arch Virol. 2021;166(3):733–53.
Kaltschmidt B, Uherek M, Volk B, Baeuerle PA, Kaltschmidt C. Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc Natl Acad Sci USA. 1997;94(6):2642–7.
Li Z, Theus MH, Wei L. Role of ERK1/2 signaling in neuronal differentiation of cultured embryonic stem cells. Develop Growth Differ. 2006;48:513–23.
Wilquet V, De Strooper B. Amyloid-β precursor protein processing in neurodegeneration. Curr Opin Neurobiol. 2004;14(5):582–8.
Li X, Cui J, Yu Y, Li W, Hou Y, Wang X, Qin D, Zhao C, Yao X, Zhao J, Pei G. Traditional Chinese nootropic medicine radix polygalae and its active constituent onjisaponin B reduce β-amyloid production and improve cognitive impairments. PLoS ONE. 2016;11(3):e0151147.
Zeng H, Li P, Zhou L, Ding K. A novel pectin from Polygala tenuifolia blocks Aβ42 aggregation and production by enhancing insulin-degradation enzyme and neprilysin. Int J Biol Macromol. 2020;161:35–43.
Park Y, Son IH, Kim B, Lyu Y, Moon H, Kang H. Poria cocos water extract (PCW) protects PC12 neuronal cells from beta-amyloid-induced cell death through antioxidant and antiapoptotic functions. Pharmazie. 2018;64(11):760–4.
Xu F, He B, Xiao F, Yan T, Bi K, Jia Y, Wang Z. Neuroprotective effects of spinosin on recovery of learning and memory in a mouse model of Alzheimer’s disease. Biomol Ther. 2019;27(1):71–7.
Tian Z, Liu SB, Wang YC, Li XQ, Zheng LH, Zhao MG. Neuroprotective effects of formononetin against NMDA-induced apoptosis in cortical neurons. Phytother Res. 2013;27(12):1770–5.
Vivian B, Bartesaghi S, Gardoni F, Vezzani A, Behrens MM, Bartfai T, Binaglia M, Corsini E, Luca MD, Galli CL, Marinovich M. Interleukin-1β enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases. J Neurosci. 2003;23(25):8692–700.
Platanias LC. Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat Rev Immunol. 2005;5(5):375–86.
Calsolaro V, Edison P. Neuroinflammation in Alzheimer’s disease: current evidence and future directions. Alzheimers Dement. 2016;12(6):719–32.
Shih RH, Wang CY, Yang CM. NFκB signaling pathways in neurological inflammation: a mini review. Front Mol Neurosci. 2015;8:77.
Sun E, Motolani A, Campos L, Lu T. The pivotal role of NFκB in the pathogenesis and therapeutics of Alzheimer’s disease. Int J Mol Sci. 2022;23:8972.
Huang YJ, Hsu NY, Lu KH, Lin YE, Lin SH, Lu YS, Liu WT, Chen MH, Sheen LY. Poria cocos water extract ameliorates the behavioral deficits induced by unpredictable chronic mild stress in rats by down-regulating inflammation. J Ethnopharmacol. 2020;258:112566.
Li W, Yu J, Zhao J, Xiao X, Li W, Zang L, Yu J, Liu H, Niu X. Poria cocos polysaccharides reduces high-fat diet-induced arteriosclerosis in ApoE-/- mice by inhibiting inflammation. Phytother Res. 2021;35(4):2220–9.
Fan Z, Liang Z, Yang H, Pan Y, Zheng Y, Wang X. Tenuigenin protects dopaminergic neurons from inflammation via suppressing NLRP3 inflammasome activation in microglia. J Neuroinflammation. 2017;14(1):256.
Lv H, Zhu C, Liao Y, Gao Y, Lu G, Zhong W, Zheng Y, Chen W, Ci X. Tenuigenin ameliorates acute lung injury by inhibiting NF-κB and MAPK signaling pathways. Respir Physiol Neurobiol. 2015;216:43–51.
Or TC, Yang CL, Law AH, Li JC, Lau AS. Isolation and identification of anti-inflammatory constituents from Ligusticum chuanxiong and their underlying mechanisms of action on microglia. Neuropharmacol. 2011;60(6):823–31.
Choi S, Aid S, Bosetti F. The distinct roles of cyclooxygenase-1 and -2 in neuroinflammation: implications for translational research. Trends Pharmacol Sci. 2009;30(4):174–81.
Dhapola R, Hota SS, Sarma P, Bhattacharyya A, Medhi B, Reddy DH. Recent advances in molecular pathways and therapeutic implications targeting neuroinflammation for Alzheimer’s disease. Inflammopharmacol. 2021;29(6):1669–81.
Dos Santos Picanco LC, Ozela PF, de de Brito Fatima, Brito M, Pinheiro AA, Padilha EC, Braga FS, da da Paula Silva CHT, Dos Santos CBR, Rosa JMC, da Dilva Hage-Melim LI. Alzheimer’s disease: a review from the pathophysiology to diagnosis, new perspectives for pharmacological treatment. Curr Med Chem. 2018;25(26):3141–59.
Kong XP, Liu E, Chen ZC, Xu ML, Yu AXD, Wu QY, Xia YJ, Duan R, Dong TTX, Tsim KWK. Synergistic inhibition of acetylcholinesterase by alkaloids derived from stephaniae tetrandrae radix, coptidis rhizoma and phellodendri Chinensis cortex. Molecules. 2019;24(24):4567.
Eom S, Kim YS, Lee SB, Noh S, Yeom HD, Bae H, Lee JH. Molecular determinants of α3β4 nicotinic acetylcholine receptors inhibition by triterpenoids. Biol Pharm Bull. 2018;41(1):65–72.
Wang X, Zhang D, Song W, Cai CF, Zhou Z, Fu Q, Yan X, Cao Y, Fang M. Neuroprotective effects of the aerial parts of Polygala tenuifolia Willd extract on scopolamine-induced learning and memory impairments in mice. Biomed Rep. 2020;13(5):37.
Moreno-Jiménez EP, Flor-García M, Terreros-Roncal J, Rábano A, Cafini F, Pallas-Bazarra N, Ávila J, Llorens-Martín M. Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease. Nat Med. 2019;25:554–60.
Chen Y, Huang X, Chen W, Wang N, Li L. Tenuigenin promotes proliferation and differentiation of hippocampal neural stem cells. Neurochem Res. 2012;37(4):771–7.
Xu XH, Zhou JF, Li TZ, Zhang ZH, Shan L, Xiang ZH. Polygalasaponin G promotes neurite outgrowth of cultured neuron on myelin. Neurosci Lett. 2009;460(1):41–6.
Song Y, Subramanian K, Berberich MJ, Rodriguez S, Latorre IJ, Luria CM, Everley R, Albers MW, Mitchison TJ, Sorger PK. A dynamic view of the proteomic landscape during differentiation of ReNcell VM cells, an immortalized human neural progenitor line. Sci Data. 2019;6:190016.
Rhim JH, Luo X, Xu X, Gao D, Zhou T, Li F, Qin L, Wang P, Xia X, Wong STC. A high-content screen identifies compounds promoting the neuronal differentiation and the midbrain dopamine neuron specification of human neural progenitor cells. Sci Rep. 2015;5:16237.
Chen X, Wu H, Chen H, Wang Q, Xie XJ, Shen J. Astragaloside VI promotes neural stem cell proliferation and enhances neurological function recovery in transient cerebral ischemic injury via activating EGFR/MAPK signaling cascades. Mol Neurobiol. 2019;56(4):3053–67.
Finkbeiner S, Tavazoie SF, Maloratsky A, Jacobs KM, Harris KM, Greenberg ME. CREB: a major mediator of neuronal neurotrophin responses. Neuron. 1997;19(5):1031–47.
Ma Q, Harris-White M, Ubeda O, Simmons M, Beech W, Lim G, Teter B, Frautschy SA, Cole GM. Evidence of Aβ- and transgene-dependent defects in ERK-CREB signaling in Alzheimer’s models. J Neurochem. 2007;103(4):1594–607.
Lee B, Cao R, Choi YS, Cho HY, Rhee AD, Hah CK, Hoyt KR, Obrietan K. The CREB/CRE transcriptional pathway: protection against oxidative stress-mediated neuronal cell death. J Neurochem. 2009;108(5):1251–65.
Ying SW, Futter M, Rosenblum K, Webber MJ, Hunt SP, Bliss TV, Bramham CR. Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis. J Neurosci. 2002;22(5):1532–40.
Ip FC, Ng YP, An HJ, Dai Y, Pang HH, Hu YQ, Chin AC, Harley CB, Wong YH, Ip NY. Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management. Neurosignals. 2014;22(1):52–63.
Liu X, Wang D, Zhao R, Dong X, Hu Y, Liu P. Synergistic neuroprotective effects of two herbal ingredients via CREB-dependent pathway. Front Pharmacol. 2016;7:337.
Dong X, Huang C, Yu B, Hu Y, Mu L, Liu P. Effect of tenuifoliside A isolated from Polygala tenuifolia on the ERK and PI3K pathways in C6 glioma cells. Phytomedicine. 2014;21(10):1178–88.
Lin Y, Wang G, Huang C, Lee Y, Liao W, Lai W, Lin Y, Huang N. Ligusticum chuaniong as a potential neuroprotectant for preventing serum deprivation-induced apoptosis in rat pheochromocytoma cells: functional roles of mitogen-activated protein kinases. J Ethnopharmacol. 2009;122(3):417–23.
Yung LY, Lam WS, Ho MKC, Hu Y, Ip FCF, Pang H, Chin AC, Harley CB, Ip NY, Wong YH. Astragaloside IV and cyclostragenol stimulate the phosphorylation of extracellular signal-regulated protein kinase in multiple cell types. Planta Med. 2012;78(2):115–21.
Ríos JL. Chemical constituents and pharmacological properties of Poria cocos. Planta Med. 2011;77(7):681–91.