Multi-parametric assessment of cardiomyocyte excitation-contraction coupling using impedance and field potential recording: A tool for cardiac safety assessment

Xiaoyu Zhang1, Liang Guo2, Haoyu Zeng3, Stephen White4, Michael Furniss2, Bharathi Balasubramanian3, Edward V. Lis3, Armando Lagrutta3, Frederick Sannajust3, Li Zhao1, Biao Xi1, Xiaobo Wang1, Mark M. Davis5, Yama Abassi1
1ACEA Biosciences Inc., San Diego, CA, 92121, USA
2Laboratory of Investigative Toxicology, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA
3SALAR, Safety & Exploratory Pharmacology Department, Merck Research Laboratories, West Point, PA 19486, USA
4Drug Synthesis & Chemistry Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
5Toxicology and Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA

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Abassi, 2012, Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment, British Journal of Pharmacology, 165, 1424, 10.1111/j.1476-5381.2011.01623.x

Bers, 2002, Cardiac excitation-contraction coupling, Nature, 415, 198, 10.1038/415198a

Bloomfield, 2015, Incorporating exposure-response modeling into the assessment of QTc interval: A potential alternative to the thorough QT study, Clinical Pharmacology & Therapeutics, 97, 444, 10.1002/cpt.92

Cavero, 2005, ICH S7B draft guideline on the non-clinical strategy for testing delayed cardiac repolarisation risk of drugs: A critical analysis, Expert Opinion on Drug Safety, 4, 509, 10.1517/14740338.4.3.509

Chaitman, 2004, Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina, Journal of the American College of Cardiology, 43, 1375, 10.1016/j.jacc.2003.11.045

Chen, 2005, QT prolongation and proarrhythmia by moxifloxacin: Concordance of preclinical models in relation to clinical outcome, British Journal of Pharmacology, 146, 792, 10.1038/sj.bjp.0706389

2008

Dennis, 2007, hERG channel trafficking: Novel targets in drug-induced long QT syndrome, Biochemical Society Transactions, 35, 1060, 10.1042/BST0351060

Fermini, 2016, A new perspective in the field of cardiac safety testing through the comprehensive in vitro proarrhythmia assay paradigm, Journal of Biomolecular Screening, 21, 1, 10.1177/1087057115594589

Gintant, 2016, Evolution of strategies to improve preclinical cardiac safety testing, Nature Reviews Drug Discovery, 10.1038/nrd.2015.34

Gualdani, 2015, Inhibition of hERG potassium channel by the antiarrhythmic agent mexiletine and its metabolite m-hydroxymexiletine, Pharmacology Research & Perspectives, 3, 10.1002/prp2.160

Guo, 2011, Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes, Toxicological Sciences, 123, 281, 10.1093/toxsci/kfr158

Guo, 2013, Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model, Toxicological Sciences, 136, 581, 10.1093/toxsci/kft205

Halbach, 2003, Estimation of action potential changes from field potential recordings in multicellular mouse cardiac myocyte cultures, Cellular Physiology and Biochemistry, 13, 271, 10.1159/000074542

Hanton, 2007, Preclinical cardiac safety assessment of drugs, Drugs in R&D, 8, 213, 10.2165/00126839-200708040-00002

Harris, 2013, Comparison of electrophysiological data from human-induced pluripotent stem cell-derived cardiomyocytes to functional preclinical safety assays, Toxicological Sciences, 134, 412, 10.1093/toxsci/kft113

Hoffmann, 2006, Are hERG channel inhibition and QT interval prolongation all there is in drug-induced torsadogenesis? A review of emerging trends, Journal of Pharmacological and Toxicological Methods, 53, 87, 10.1016/j.vascn.2005.07.003

Kallergis, 2012, Mechanisms, risk factors, and management of acquired long QT syndrome: A comprehensive review, ScientificWorld Journal, 2012, 212178, 10.1100/2012/212178

Kannankeril, 2010, Drug-induced long QT syndrome, Pharmacological Reviews, 62, 760, 10.1124/pr.110.003723

Katz, 2000, Regulation of cardiac contraction and relaxation, Circulation, 102, IV69

Kovacs, 2004, Mechanism of blebbistatin inhibition of myosin II, The Journal of Biological Chemistry, 279, 35557, 10.1074/jbc.M405319200

Lacerda, 2008, Alfuzosin delays cardiac repolarization by a novel mechanism, Journal of Pharmacology and Experimental Therapeutics, 324, 427, 10.1124/jpet.107.128405

Lamore, 2013, Cellular impedance assays for predictive preclinical drug screening of kinase inhibitor cardiovascular toxicity, Toxicological Sciences, 135, 402, 10.1093/toxsci/kft167

Limame, 2012, Comparative analysis of dynamic cell viability, migration and invasion assessments by novel real-time technology and classic endpoint assays, PloS One, 7, 10.1371/journal.pone.0046536

Mirams, 2014, Prediction of thorough QT study results using action potential simulations based on ion channel screens, Journal of Pharmacological and Toxicological Methods, 70, 246, 10.1016/j.vascn.2014.07.002

Paul, 2002, Inhibition of the current of heterologously expressed HERG potassium channels by flecainide and comparison with quinidine, propafenone and lignocaine, British Journal of Pharmacology, 136, 717, 10.1038/sj.bjp.0704784

Peters, 2012, Evaluation of cellular impedance measures of cardiomyocyte cultures for drug screening applications, Assay and Drug Development Technologies, 10, 525, 10.1089/adt.2011.442

Redfern, 2003, Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: Evidence for a provisional safety margin in drug development, Cardiovascular Research, 58, 32, 10.1016/S0008-6363(02)00846-5

Remme, 2010, Sodium channel (dys)function and cardiac arrhythmias, Cardiovascular Therapeutics, 28, 287, 10.1111/j.1755-5922.2010.00210.x

Sager, 2014, Rechanneling the cardiac proarrhythmia safety paradigm: A meeting report from the Cardiac Safety Research Consortium, American Heart Journal, 167, 292, 10.1016/j.ahj.2013.11.004

Schram, 2004, Ranolazine: Ion-channel-blocking actions and in vivo electrophysiological effects, British Journal of Pharmacology, 142, 1300, 10.1038/sj.bjp.0705879

Schweikart, 2013, The effects of jaspamide on human cardiomyocyte function and cardiac ion channel activity, Toxicology In Vitro, 27, 745, 10.1016/j.tiv.2012.12.005

Scott, 2014, An impedance-based cellular assay using human iPSC-derived cardiomyocytes to quantify modulators of cardiac contractility, Toxicological Sciences, 142, 331, 10.1093/toxsci/kfu186

Tamargo, 2004, Pharmacology of cardiac potassium channels, Cardiovascular Research, 62, 9, 10.1016/j.cardiores.2003.12.026

Towart, 2009, Blockade of the I(Ks) potassium channel: An overlooked cardiovascular liability in drug safety screening?, Journal of Pharmacological and Toxicological Methods, 60, 1, 10.1016/j.vascn.2009.04.197

Tzeis, 2012, Antiarrhythmic properties of ranolazine–from bench to bedside, Expert Opinion on Investigational Drugs, 21, 1733, 10.1517/13543784.2012.716826

Veerman, 2013, Slow delayed rectifier potassium current blockade contributes importantly to drug-induced long QT syndrome, Circulation. Arrhythmia and Electrophysiology, 6, 1002, 10.1161/CIRCEP.113.000239

Wallis, 2010, Integrated risk assessment and predictive value to humans of non-clinical repolarization assays, British Journal of Pharmacology, 159, 115, 10.1111/j.1476-5381.2009.00395.x

Xi, 2011, Functional cardiotoxicity profiling and screening using the xCELLigence RTCA Cardio System, Journal of Laboratory Automation, 16, 415, 10.1016/j.jala.2011.09.002