Multi-gene vaccination against malaria: A multistage, multi-immune response approach

World Health Organization, 1994, World malaria situation in 1992, Weekly Epidemiol. Rec., 69, 309

1996, 15

1996, 181

Doolan, 1992, Geographically restricted heterogeneity of the Plasmodium falciparum circumsporozite protein: relevance for vaccine development, Infect. Immun., 60, 675, 10.1128/IAI.60.2.675-682.1992

Miller, 1993, Analysis of sequence diverstity in the Plasmodium falciparum merozoite surface protein-1 (MSP-1), Mol. Biochem. Parasitol., 59, 1, 10.1016/0166-6851(93)90002-F

Borst, 1995, Antigenic variation in malaria, Cell, 82, 1, 10.1016/0092-8674(95)90044-6

Sim, 1994, Receptor and ligand do mains for invasion of erythrocytes by Plasmodium falciparum, Science, 264, 1941, 10.1126/science.8009226

Chitinis, 1994, Identification of the erythrocyte binding domain of Plasmodium vivax and Plasmodium knowlesi proteins involved in erythrocyte invasion, J. Exp. Med., 180, 497, 10.1084/jem.180.2.497

Nussenzweig, 1969, Specificity of protective immunity produced by X-irradiated Plasmodium berghei sporozoites, Nature, 222, 488, 10.1038/222488a0

Gwadz, 1979, Preliminary studies on vaccination of rhesus monkeys with irradiated sporozoites of Plasmodium knowlesi and characterization of surface antigens of these parasites, Bull. WHO, 57, 165

Clyde, 1973, Immunization of man against sporozoite-induced falciparum malaria, Am. J. Med. Sci., 266, 169, 10.1097/00000441-197309000-00002

Clyde, 1973, Specificity of protection of man immunized against sporozoite-induced falciparum malaria, Am. J Med. Sci., 266, 398, 10.1097/00000441-197312000-00001

Clyde, 1975, Immunization of man against falciparum and vivax malaria by use of attenuated sporozoites, Am. J. Trop. Med. Hyg., 24, 397, 10.4269/ajtmh.1975.24.397

Rieckmann, 1974, Sporozoite induced immunity in man against an Ethiopian strain of Plasmodium falciparum, Trans. R. Soc. Trop. Med. Hyg., 68, 258, 10.1016/0035-9203(74)90129-1

Herrington, 1991, Successful immunization of humans with irradiated malaria sporozoites: humoral and cellular responses of the protected individuals, Am. J. Trop. Med. Hyg., 45, 539, 10.4269/ajtmh.1991.45.539

Rieckmann, 1979, Use of attenuated sporozoites in the immunization of human volunteers against falciparum malaria, Bull. WHO, 57, 261

Egan, 1993, Humoral immune response in volunteers immunized with irradiated Plasmodium falciparum sporozoites, Am. J. Trop. Med. Hyg., 49, 166, 10.4269/ajtmh.1993.49.166

Edelman, 1993, Long-term persistence of sterile immunity in a volunteer immunized with X-irradiated Plasmodium falciparum sporozoites, J. Infect. Dis., 168, 1066, 10.1093/infdis/168.4.1066

Mitchell, 1975, Merozoite vaccination against Plasmodium knowlesi malaria, Immunology, 29, 397

Cohen, 1961, Gamma-globulin and acquired immunity to human malaria, Nature, 192, 733, 10.1038/192733a0

McGregor, 1963, Treatment of East Africa P. falciparum malaria with West African human gamma-globulin, Trans. R. Soc. Trop. Med. Hyg., 57, 170, 10.1016/0035-9203(63)90058-0

Sabchareon, 1991, Parasitological and clinical human response to immunoglobulin administration in falciparum malaria, Am. J. Trop. Med. Hyg., 45, 297, 10.4269/ajtmh.1991.45.297

Huff, 1958, Changes in infectiousness of malarial gametocytes. II. It Analysis of the possible causative factors, Exp . Parasitol., 7, 399, 10.1016/0014-4894(58)90036-5

Baird, 1995, Host age as a determinant of naturally acquired immunity to Plasmodium falciparum, Parasitol. Today, 11, 105, 10.1016/0169-4758(95)80167-7

Stoute, 1997, A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria, New Engl. J. Med., 336, 86, 10.1056/NEJM199701093360202

Collins, 1964, Fluorescent antibody studies in human malaria 3. Development of antibodies to Plasmodium falciparum in semi-immune patients, Am. J. Trop. Med. Hyg., 13, 777, 10.4269/ajtmh.1964.13.777

Bouharoun Tayoun, 1990, Antibodies that protect humans against Plasmodium falciparum blood stages do not on their own inhibit parasite growth and invasion in vitro, but act in cooperation with monocytes, J. Exp. Med., 172, 1633, 10.1084/jem.172.6.1633

Diggs, 1972, The protective effect of African human immunoglobulin G in Aotus trivirgatus infected with Asian Plasmodium falciparum, Pros. Helminth. Soc. Washington, 42, 427

Voller, 1969, Immunological studies on simian malaria. III. Immunity to challenge and antigenic variation in P. knowlesi, Trans. R. Soc. Trop. Med. Hyg., 63, 507, 10.1016/0035-9203(69)90040-6

Khusmith, 1991, Protection against malaria by vaccination with sporozoite surface protein 2 plus CS protein, Science, 252, 715, 10.1126/science.1827210

1995, Vol. 72, 1

Robertson, 1994, Safety considerations for nucleic acid vaccines, Vaccine, 12, 1526, 10.1016/0264-410X(94)90077-9

Griffiths, 1995, Assuring the safety and efficacy of DNA vaccines, Ann. New York Acad. Sci., 772, 164, 10.1111/j.1749-6632.1995.tb44741.x

Nichols, 1995, Potential DNA vaccine integration into the host genome, Ann. New York Acad. Sci., 772, 30, 10.1111/j.1749-6632.1995.tb44729.x

Wolff, 1992, Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle, Hum. Mol. Genet., 1, 363, 10.1093/hmg/1.6.363

Ulmer, 1993, Heterologous protection against influenza by injection of DNA encoding a viral protein, Science, 259, 1745, 10.1126/science.8456302

Charoenvit, 1991, Inability of malaria vaccine to induce antibodies to a protective epitope within its sequence, Science, 251, 668, 10.1126/science.1704150

Sedegah, 1994, Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein, 91, 9866

Doolan, 1996, Circumventing genetic restriction of protection against malaria with multi-gene DNA immunízation: CD8+ T cell, interferon-γ, and nitric oxide dependent immunity, J. Exp. Med., 183, 1739, 10.1084/jem.183.4.1739

Huygen, 1996, Immunogenicity and protective efficacy of a tuberculosis DNA vaccine, Nat. Med., 2, 893, 10.1038/nm0896-893

Xu, 1994, Genetic vaccination against Leishmaniasis, Vaccine, 12, 1535, 10.1016/0264-410X(94)90079-5

Barry, 1995, Protection against mycoplasma infection using expression-library immunization, Nature, 377, 632, 10.1038/377632a0

Yang, 1995, Antibodies to Schistosoma japonicum (Asian bloodfluke) paramyocin induced by nucleic acid vaccination, Biochem. Biophys. Res. Commun., 212, 1029, 10.1006/bbrc.1995.2073

Donnelly, 1996, Protection against Papillomavirus with a polynucleotide vaccine, J. Infect. Dis., 713, 314, 10.1093/infdis/173.2.314

Whitton, 1993, A “string of beads” vaccine, comprising linked minigenes, confers protection from lethal-dose virus challenge, J. Virol., 67, 348, 10.1128/JVI.67.1.348-352.1993

Thomson, 1995, Minimal epitopes expressed in a recombinant polyepitope protein are processed and presented to CD8+ cytotoxic T cells: implications for vaccine design, 92, 5845

Doolan, 1996, Characterization of the protective Hepatocyte Erythrocyte Protein 17 kDa gene of Plasmodium yoelii: homolog of P. falciparum Exported Protein-1, J. Biol. Chem., 271, 17861, 10.1074/jbc.271.30.17861

Collins, 1994, Selection of different strains of Plasmodium falciparum for testing bloodstage vaccines in Aotus nancymai monkeys, Am. J. Trop. Med. Hyg., 51, 224, 10.4269/ajtmh.1994.51.224

Gramzinski, 1996, Optimization of antibody responses of a malaria DNA vaccine in Aotus monkeys, Vaccine Res., 5, 173

Manickan, 1995, Genetic immunization against Herpes simplex virus, 155, 259

Ling, 1994, Immunization against malaria with a recombinant protein, Parasite Immunol., 16, 63, 10.1111/j.1365-3024.1994.tb00324.x

Rosenberg, 1990, An estimation of the number of malaria sporozoites ejected by a feeding mosquito, Trans. R. Soc. Trop. Med. Hyg., 84, 209, 10.1016/0035-9203(90)90258-G

Weiss, 1989, Genetic control of immunity to Plasmodium yoelii sporozoites, J. Immunol., 143, 4263, 10.4049/jimmunol.143.12.4263