Multi-ancestry genome-wide gene–sleep interactions identify novel loci for blood pressure

Molecular Psychiatry - Tập 26 Số 11 - Trang 6293-6304 - 2021
Heming Wang1, Raymond Noordam2, Ulrich Broeckel1, Karen Schwander3, Thomas W. Winkler4, Jiwon Lee1, Yan V. Sun3, Amy R. Bentley5, Alisa K. Manning6, Hugues Aschard7, Tuomas O. Kilpeläinen8, Marjan Ilkov9, Michael R. Brown10, A.R.V.R. Horimoto11, Melissa A. Richard12, Traci M. Bartz13, Dina Vojinović14, Elise Lim15, Jovia L. Nierenberg16, Yongmei Liu17, Kumaraswamy Naidu Chitrala18, Albert Hofman19, Solomon K. Musani20, Nora Franceschini21, Rainer Rauramaa22, Maris Laan23, Phyllis C. Zee24, Sarah E. Harris25, Peter J. van der Most26, Ilja M. Nolte26, Patricia B. Munroe27, Nicholette D. Palmer28, Karin Leander29, Stefan Weiß30, Wanqing Wen31, Kelly Hall32, Leo‐Pekka Lyytikäinen33, Jeff O’Connell34, Guðný Eiríksdóttir9, Lenore J. Launer18, Paul S. de Vries10, Dan E. Arking35, Han Chen10, Eric Boerwinkle10, José Eduardo Krieger11, Pamela J. Schreiner36, Stephen Sidney37, James M. Shikany38, Kenneth Rice39, Yii‐Der Ida Chen40, Sina A. Gharib41, Joshua C. Bis13, Annemarie I. Luik14, M. Arfan Ikram14, André G. Uitterlinden14, Najaf Amin14, Hanfei Xu15, Daniel Levy15, Jiang He16, Kurt K. Lohman17, Alan B. Zonderman18, Treva Rice3, Tanika N. Kelly20, Gregory Wilson42, Tamar Sofer6, Stephen S. Rich43, Cornelia M. van Duijn44, Jie Yao40, Xiuqing Guo40, Jerome I. Rotter40, Nienke R. Biermasz45, Colin N. A. Palmer46, Lisa W. Martin47, Ana Barac48, Robert B. Wallace49, Daniel J. Gottlieb50, Sami Heikkinen51, Reedik Mägi23, Lili Milani23, Andres Metspalu23, John M. Starr52, Yuri Milaneschi53, R. J. Waken54, Chuan Gao55, Mélanie Waldenberger29, Annette Peters56, Konstantin Strauch57, Thomas Meitinger58, Till Roenneberg59, Uwe Völker30, Marcus Dörr60, Xiao‐Ou Shu31, Sutapa Mukherjee61, David R. Hillman62, Mika Kähönen63, Lynne E. Wagenknecht64, Christian Gieger29, Hans J. Grabe65, Wei Zheng31, Lyle J. Palmer32, Terho Lehtimäki33, Vilmundur Guðnason66, Alanna C. Morrison10, Alexandre C. Pereira67, Myriam Fornage12, Bruce M. Psaty68, Michele K. Evans18, Claude Bouchard19, Ervin R. Fox20, Charles Kooperberg69, Xiaofeng Zhu70, Timo A. Lakka51, Tõnu Esko23, Kari E. North21, Ian J. Deary25, Harold Snieder26, Brenda W.J.H. Penninx53, W. James Gauderman71, D. C. Rao3, Susan Redline72, Diana O. Perkins2
1Division of Sleep and Circadian Disorders, Brigham and Women's Hospital & Harvard Medical School, Boston, MA, USA
2Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
3Division of Biostatistics, Washington University School of Medicine, St. Louis, Mo. USA
4Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany
5Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
6Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
7Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA;
8Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
9Icelandic Heart Association, Kopavogur, Iceland
10Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA
11Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil
12Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA
13Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA
14Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
15Department of Biostatistics, Boston University School of Public Health, Boston, MA USA
16Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA
17Division of Cardiology, Department of Medicine, Duke Molecular Physiology Institute Duke University School of Medicine, Durham, NC, USA
18Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA
19Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA
20Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA
21Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA
22Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
23Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia
24Division of Sleep Medicine, Department of Neurology, Northwestern University, Chicago, IL, USA
25Lothian Birth Cohorts Group, Department of Psychology, University of Edinburgh, Edinburgh, UK
26Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
27Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
28Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA
29Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
30Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University Medicine Greifswald, Greifswald, Germany
31Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
32School of Public Health, The University of Adelaide, Adelaide, SA, Australia
33Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland
34Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA
35McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
36Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
37Kaiser Permanente Northern California, Oakland, CA, USA
38Division of Preventive Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
39Department of Biostatistics, University of Washington, Seattle, WA USA
40The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA
41Computational Medicine Core, Center for Lung Biology, UW Medicine Sleep Center, Department of Medicine, University of Washington, Seattle, WA, USA
42JHS Graduate Training and Education Center, Jackson State University, Jackson, MS, USA
43Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA
44Division of General Medicine, Department of Medicine, Columbia University, New York, NY, USA
45Division of Endocrinology, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands
46Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
47George Washington University School of Medicine and Health Sciences, Washington DC, USA
48MedStar Heart and Vascular Institute, Washington, DC, USA
49Department of Epidemiology, University of Iowa College of Public Health, Iowa City, IA, USA
50VA Boston Healthcare System, Boston, MA, USA.
51Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Finland
52Alzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh, UK
53Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit, Amsterdam, HJ, The Netherlands
54Division of Cardiology, Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA
55Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, NC, USA
56Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany
57Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany
58Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg Germany
59Institute and Polyclinic for Occupational-, Social- and Environmental Medicine, LMU Munich, Munich, Germany
60German Center for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany
61Sleep Health Service, Respiratory and Sleep Services, Southern Adelaide Local Health Network, Adelaide, SA, Australia
62Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Perth, WA, Australia
63Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland
64Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA
65Department Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
66Faculty of Medicine, University of Iceland, Reykjavik, Iceland
67Department of Genetics, Harvard Medical School, Boston, MA, USA
68Cardiovascular Health Research Unit, Departments of Epidemiology and Health Services, University of Washington, Seattle, WA, USA
69Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
70Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA
71Division of Biostatistics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA
72Division of Pulmonary Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA

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Molecular Psychiatry

Tập 26 Số 11

6293-6304

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