Multi-System Inflammatory Syndrome in a Child Mimicking Kawasaki Disease

Journal of Tropical Pediatrics - Tập 67 Số 3 - 2021
Aman Gupta1, Arpinder Gill2, Manu Sharma2, Megha Garg3
1Department of Pediatric Rheumatology & Immunology, MEDENS Hospital, Panchkula 134113, Haryana, India
2Department of Pediatrics and Neonatology, Max Super Speciality Hospital, Mohali 160055, Punjab, India
3Department of Dermatology & Cosmetology, MEDENS Hospital, Panchkula 134113, Haryana, India

Tóm tắt

Abstract There have been recent reports of children presenting with severe multi-system hyperinflammatory syndrome resembling Kawasaki disease (KD) during current COVID-19 pandemic. Exact pathophysiology is unknown, however, most of the children have multi-organ dysfunction and respiratory system involvement is less common compared to adults. These patients have certain characteristic laboratory parameters different from those seen in children with KD. However, only limited literature is available at present for identification and management of such patients. We report a young girl who presented with fever, rash and other manifestations mimicking classic KD and fulfilling the case definitions for pediatric multi-system inflammatory syndrome. She had lymphopenia, thrombocytopenia and hyponatremia in the absence of macrophage activation syndrome, similar to that seen in patients reported from UK and Italy. Clinical manifestations resolved and laboratory parameters improved with intravenous immunoglobulin and corticosteroids. Early recognition is important to administer immunomodulatory therapy which may be life saving for these patients.

Từ khóa


Tài liệu tham khảo

Riphagen, 2020, Hyperinflammatory shock in children during COVID-19 pandemic, Lancet, 395, 1607, 10.1016/S0140-6736(20)31094-1

Gupta, 2016, Kawasaki disease for dermatologists, Indian Dermatol, 7, 461, 10.4103/2229-5178.193903

Verdoni, 2020, An outbreak of severe Kawasaki like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study, Lancet, 395, 1771, 10.1016/S0140-6736(20)31103-X

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Journal of Tropical Pediatrics

Tập 67 Số 3

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