Multi-Parametric Magnetic Resonance Imaging to Rule-In and Rule-Out Clinically Important Prostate Cancer in Men at Risk: A Cohort Study

Urologia Internationalis - Tập 87 Số 1 - Trang 49-53 - 2011
Paul Rouse1, Greg Shaw1, Hashim U. Ahmed1, Alex Freeman2, Clare Allen3, Mark Emberton1
1Division of Surgery and Interventional Science, University College London, Departments of
2Histopathology, University College London Hospitals NHS Foundation Trust, and
3Academic Radiology and

Tóm tắt

<i>Objectives:</i> Overdiagnosis is arguably the greatest challenge in the management of men with prostate cancer. Multi-parametric (mp)-MRI prior to prostate biopsy may have a role in ruling-in and ruling-out clinically significant disease. <i>Patients and Methods:</i> 114 consecutive men at risk of prostate cancer with previous biopsy underwent mp-MRI prior to transrectal ultrasound (TRUS)-guided biopsies. Standard systematic biopsies were carried out with targeting to suspicious areas. <i>Results:</i> 59.6% had cancer detected by TRUS-guided biopsy. Mean age was 63.6 years (SD 9.0). If men had not been biopsied because of a negative mp-MRI, 21% (24/114) with no cancer and 5% (6/114) with clinically insignificant cancer could have avoided a biopsy. However, 4% (4/114) would have been advised to defer a biopsy that demonstrated the presence of clinically significant cancer. <i>Conclusion:</i> mp-MRI may have a role in ruling-in and ruling-out clinically significant prostate cancer in men at risk prior to biopsy.

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Urologia Internationalis

Tập 87 Số 1

49-53

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