Mucosal macrophages and the regulation of immune responses in the intestine

Lee, 1985, Quantitative analysis of total macrophage content in adult mouse tissues Immunochemical studies with monoclonal antibody F4/80, J Exp Med, 161, 475, 10.1084/jem.161.3.475

Macpherson, 2004, Interactions between commensal intestinal bacteria and the immune system, Nat Rev Immunol, 4, 478, 10.1038/nri1373

Sellon, 1998, Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice, Infect Immun, 66, 5224, 10.1128/IAI.66.11.5224-5231.1998

Strober, 2002, The immunology of mucosal models of inflammation, Annu Rev Immunol, 20, 495, 10.1146/annurev.immunol.20.100301.064816

Sutherland, 1991, Double blind, placebo controlled trial of metronidazole in Crohn's disease, Gut, 32, 1071, 10.1136/gut.32.9.1071

Turunen, 1998, Long-term treatment of ulcerative colitis with ciprofloxacin: a prospective, double-blind, placebo-controlled study, Gastroenterology, 115, 1072, 10.1016/S0016-5085(98)70076-9

Inohara, 2003, Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease, J Biol Chem, 278, 5509, 10.1074/jbc.C200673200

Hugot, 2001, Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease, Nature, 411, 599, 10.1038/35079107

Ogura, 2001, A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease, Nature, 411, 603, 10.1038/35079114

Smith, 2007, Infection with a helminth parasite prevents experimental colitis via a macrophage-mediated mechanism, J Immunol, 178, 4557, 10.4049/jimmunol.178.7.4557

Hirotani, 2005, The nuclear IκB protein IκBNS selectively inhibits lipopolysaccharide-induced IL-6 production in macrophages of the colonic lamina propria, J Immunol, 174, 3650, 10.4049/jimmunol.174.6.3650

Rogler, 1998, Isolation and phenotypic characterization of colonic macrophages, Clin Exp Immunol, 112, 205, 10.1046/j.1365-2249.1998.00557.x

Smythies, 2005, Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity, J Clin Invest, 115, 66, 10.1172/JCI200519229

Niess, 2005, CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance, Science, 307, 254, 10.1126/science.1102901

Chieppa, 2006, Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement, J Exp Med, 203, 2841, 10.1084/jem.20061884

Mowat, 2003, Anatomical basis of tolerance and immunity to intestinal antigens, Nat Rev Immunol, 3, 331, 10.1038/nri1057

Hornef, 2003, Intracellular recognition of lipopolysaccharide by toll-like receptor 4 in intestinal epithelial cells, J Exp Med, 198, 1225, 10.1084/jem.20022194

Hornef, 2002, Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cells, J Exp Med, 195, 559, 10.1084/jem.20011788

Eckmann, 1993, Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry, Infect Immun, 61, 4569, 10.1128/IAI.61.11.4569-4574.1993

Reinecker, 1995, Monocyte-chemoattractant protein 1 gene expression in intestinal epithelial cells and inflammatory bowel disease mucosa, Gastroenterology, 108, 40, 10.1016/0016-5085(95)90006-3

Macpherson, 2004, Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria, Science, 303, 1662, 10.1126/science.1091334

Smith, 2001, Intestinal macrophages lack CD14 and CD89 and consequently are down-regulated for LPS- and IgA-mediated activities, J Immunol, 167, 2651, 10.4049/jimmunol.167.5.2651

Golenbock, 1991, Lipid A-like molecules that antagonize the effects of endotoxins on human monocytes, J Biol Chem, 266, 19490, 10.1016/S0021-9258(18)55023-7

Hooper, 2002, How host-microbial interactions shape the nutrient environment of the mammalian intestine, Annu Rev Nutr, 22, 283, 10.1146/annurev.nutr.22.011602.092259

Weintraub, 1989, Structural characterization of the lipid A component of Bacteroides fragilis strain NCTC 9343 lipopolysaccharide, Eur J Biochem, 183, 425, 10.1111/j.1432-1033.1989.tb14945.x

Kamada, 2005, Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria, J Immunol, 175, 6900, 10.4049/jimmunol.175.10.6900

Mahida, 1989, Respiratory burst activity of intestinal macrophages in normal and inflammatory bowel disease, Gut, 30, 1362, 10.1136/gut.30.10.1362

Ikeda, 1997, Distribution of inducible nitric oxide synthase in ulcerative colitis, Am J Gastroenterol, 92, 1339

Roberts, 2001, The physiological expression of inducible nitric oxide synthase (iNOS) in the human colon, J Clin Pathol, 54, 293, 10.1136/jcp.54.4.293

Hausmann, 2002, Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation, Gastroenterology, 122, 1987, 10.1053/gast.2002.33662

Kielian, 1995, CD14 and other recognition molecules for lipopolysaccharide: a review, Immunopharmacology, 29, 187, 10.1016/0162-3109(95)00003-C

Grimm, 1995, Evidence for a CD14+ population of monocytes in inflammatory bowel disease mucosa—implications for pathogenesis, Clin Exp Immunol, 100, 291, 10.1111/j.1365-2249.1995.tb03667.x

Nakata, 2006, Specific messenger RNA expression for signal transduction molecules by lipopolysaccharide in intestinal macrophages, Clin Exp Immunol, 143, 484, 10.1111/j.1365-2249.2006.03014.x

Monteleone, 2008, IL-10-dependent partial refractoriness to Toll-like receptor stimulation modulates gut mucosal dendritic cell function, Eur J Immunol, 10.1002/eji.200737909

Gorter, 1987, IgA- and secretory IgA-opsonized S. aureus induce a respiratory burst and phagocytosis by polymorphonuclear leucocytes, Immunology, 61, 303

Schenk, 2005, Macrophages expressing triggering receptor expressed on myeloid cells-1 are underrepresented in the human intestine, J Immunol, 174, 517, 10.4049/jimmunol.174.1.517

Bouchon, 2000, Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes, J Immunol, 164, 4991, 10.4049/jimmunol.164.10.4991

Schenk, 2007, TREM-1-expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases, J Clin Invest, 117, 3097, 10.1172/JCI30602

Chung, 2007, Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1, Immunity, 27, 952, 10.1016/j.immuni.2007.11.014

Nomura, 2000, Cutting edge: endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression, J Immunol, 164, 3476, 10.4049/jimmunol.164.7.3476

Medvedev, 2002, Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells, J Immunol, 169, 5209, 10.4049/jimmunol.169.9.5209

Adib-Conquy, 2002, Gamma interferon and granulocyte/monocyte colony-stimulating factor prevent endotoxin tolerance in human monocytes by promoting interleukin-1 receptor-associated kinase expression and its association to MyD88 and not by modulating TLR4 expression, J Biol Chem, 277, 27927, 10.1074/jbc.M200705200

Hedl, 2007, Chronic stimulation of Nod2 mediates tolerance to bacterial products, Proc Natl Acad Sci USA, 104, 19440, 10.1073/pnas.0706097104

Wang, 2002, Induction of bacterial lipoprotein tolerance is associated with suppression of toll-like receptor 2 expression, J Biol Chem, 277, 36068, 10.1074/jbc.M205584200

Randow, 2001, Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability, Nat Cell Biol, 3, 891, 10.1038/ncb1001-891

Yang, 2007, Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages, Immunity, 26, 215, 10.1016/j.immuni.2006.12.005

Schreiter, 2005, Glycoprotein (gp) 96 expression: induced during differentiation of intestinal macrophages but impaired in Crohn's disease, Gut, 54, 935, 10.1136/gut.2004.053116

Chuang, 2004, Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors, Nat Immunol, 5, 495, 10.1038/ni1066

Contractor, 2007, Cutting edge: Peyer's patch plasmacytoid dendritic cells (pDCs) produce low levels of type I interferons: possible role for IL-10, TGFβ, and prostaglandin E2 in conditioning a unique mucosal pDC phenotype, J Immunol, 179, 2690, 10.4049/jimmunol.179.5.2690

Iwata, 2004, Retinoic acid imprints gut-homing specificity on T cells, Immunity, 21, 527, 10.1016/j.immuni.2004.08.011

Zaph, 2007, Epithelial-cell-intrinsic IKKβ expression regulates intestinal immune homeostasis, Nature, 446, 552, 10.1038/nature05590

Tsunawaki, 1988, Deactivation of macrophages by transforming growth factor-β, Nature, 334, 260, 10.1038/334260a0

Bogdan, 1991, Macrophage deactivation by interleukin 10, J Exp Med, 174, 1549, 10.1084/jem.174.6.1549

Autschbach, 1996, In situ expression of interleukin-10 messenger RNA in Crohn disease and ulcerative colitis, Verh Dtsch Ges Pathol, 80, 218

Avery, 1993, TGFβ expression in the human colon: differential immunostaining along crypt epithelium, Br J Cancer, 68, 137, 10.1038/bjc.1993.301

Arranz, 2008, Vasoactive intestinal peptide suppresses toll-like receptor 4 expression in macrophages via Akt1 reducing their responsiveness to lipopolysaccharide, Mol Immunol, 45, 2970, 10.1016/j.molimm.2008.01.023

Delgado, 2006, Vasoactive intestinal peptide: the dendritic cell→regulatory T cell axis, Ann N Y Acad Sci, 1070, 233, 10.1196/annals.1317.020

Spottl, 2001, Monocyte differentiation in intestine-like macrophage phenotype induced by epithelial cells, J Leukoc Biol, 70, 241, 10.1189/jlb.70.2.241

Asseman, 1999, An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation, J Exp Med, 190, 995, 10.1084/jem.190.7.995

Randow, 1995, Mechanism of endotoxin desensitization: involvement of interleukin 10 and transforming growth factor β, J Exp Med, 181, 1887, 10.1084/jem.181.5.1887

Moreno, 2004, Anti-inflammatory cytokines induce lipopolysaccharide tolerance in human monocytes without modifying toll-like receptor 4 membrane expression, Scand J Immunol, 59, 553, 10.1111/j.0300-9475.2004.01445.x

Schottelius, 1999, Interleukin-10 signaling blocks inhibitor of κB kinase activity and nuclear factor κB DNA binding, J Biol Chem, 274, 31868, 10.1074/jbc.274.45.31868

Kuwata, 2003, IL-10-inducible Bcl-3 negatively regulates LPS-induced TNFα production in macrophages, Blood, 102, 4123, 10.1182/blood-2003-04-1228

Naiki, 2005, Transforming growth factor-β differentially inhibits MyD88-dependent, but not TRAM- and TRIF-dependent, lipopolysaccharide-induced TLR4 signaling, J Biol Chem, 280, 5491, 10.1074/jbc.C400503200

Zeng, 2007, TREM-1 expression in macrophages is regulated at transcriptional level by NFκB and PU 1, Eur J Immunol, 37, 2300, 10.1002/eji.200737270

Hoek, 2000, Down-regulation of the macrophage lineage through interaction with OX2 (CD200), Science, 290, 1768, 10.1126/science.290.5497.1768

Broderick, 2002, Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis, Am J Pathol, 161, 1669, 10.1016/S0002-9440(10)64444-6

Jenmalm, 2006, Regulation of myeloid cell function through the CD200 receptor, J Immunol, 176, 191, 10.4049/jimmunol.176.1.191

Zhang, 2004, Molecular mechanisms of CD200 inhibition of mast cell activation, J Immunol, 173, 6786, 10.4049/jimmunol.173.11.6786

Fogg, 2006, A clonogenic bone marrow progenitor specific for macrophages and dendritic cells, Science, 311, 83, 10.1126/science.1117729

Randolph, 2002, The CD16+ (FcγRIII+) subset of human monocytes preferentially becomes migratory dendritic cells in a model tissue setting, J Exp Med, 196, 517, 10.1084/jem.20011608

Geissmann, 2003, Blood monocytes consist of two principal subsets with distinct migratory properties, Immunity, 19, 71, 10.1016/S1074-7613(03)00174-2

Crofton, 1978, The origin, kinetics, and characteristics of the Kupffer cells in the normal steady state, J Exp Med, 148, 1, 10.1084/jem.148.1.1

Matute-Bello, 2004, Optimal timing to repopulation of resident alveolar macrophages with donor cells following total body irradiation and bone marrow transplantation in mice, J Immunol Methods, 292, 25, 10.1016/j.jim.2004.05.010

Tarling, 1987, Self-renewal of pulmonary alveolar macrophages: evidence from radiation chimera studies, J Leukoc Biol, 42, 443, 10.1002/jlb.42.5.443

Grimm, 1995, Direct evidence of monocyte recruitment to inflammatory bowel disease mucosa, J Gastroenterol Hepatol, 10, 387, 10.1111/j.1440-1746.1995.tb01589.x

Rugtveit, 1994, Increased macrophage subset in inflammatory bowel disease: apparent recruitment from peripheral blood monocytes, Gut, 35, 669, 10.1136/gut.35.5.669

Kuhn, 1993, Interleukin-10-deficient mice develop chronic enterocolitis, Cell, 75, 263, 10.1016/0092-8674(93)80068-P

Takeda, 1999, Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils, Immunity, 10, 39, 10.1016/S1074-7613(00)80005-9

Tebbutt, 2002, Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice, Nat Med, 8, 1089, 10.1038/nm763

Denning, 2007, Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses, Nat Immunol, 8, 1086, 10.1038/ni1511

Lin, 2005, The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance, J Exp Med, 201, 1615, 10.1084/jem.20042307

Qualls, 2006, Suppression of experimental colitis by intestinal mononuclear phagocytes, J Leukoc Biol, 80, 802, 10.1189/jlb.1205734

Rakoff-Nahoum, 2004, Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis, Cell, 118, 229, 10.1016/j.cell.2004.07.002

Rakoff-Nahoum, 2006, Role of toll-like receptors in spontaneous commensal-dependent colitis, Immunity, 25, 319, 10.1016/j.immuni.2006.06.010

Gibson, 2008, Toll-like receptor 2 plays a critical role in maintaining mucosal integrity during Citrobacter rodentium-induced colitis, Cell Microbiol, 10, 388

Pull, 2005, Activated macrophages are an adaptive element of the colonic epithelial progenitor niche necessary for regenerative responses to injury, Proc Natl Acad Sci USA, 102, 99, 10.1073/pnas.0405979102

Katakura, 2005, Toll-like receptor 9-induced type I IFN protects mice from experimental colitis, J Clin Invest, 115, 695, 10.1172/JCI22996

Lee, 2006, Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells, Nat Cell Biol, 8, 1327, 10.1038/ncb1500

Wenneras, 2000, Blockade of CD14 increases Shigella-mediated invasion and tissue destruction, J Immunol, 164, 3214, 10.4049/jimmunol.164.6.3214

Yrlid, 2000, Salmonella-induced apoptosis of infected macrophages results in presentation of a bacteria-encoded antigen after uptake by bystander dendritic cells, J Exp Med, 191, 613, 10.1084/jem.191.4.613

Hausmann, 2005, Physiological role of macrophage inflammatory protein-3 alpha induction during maturation of intestinal macrophages, J Immunol, 175, 1389, 10.4049/jimmunol.175.3.1389

Salazar-Gonzalez, 2006, CCR6-mediated dendritic cell activation of pathogen-specific T cells in Peyer's patches, Immunity, 24, 623, 10.1016/j.immuni.2006.02.015

Little, 2005, The characterization of intraepithelial lymphocytes, lamina propria leukocytes, and isolated lymphoid follicles in the large intestine of mice infected with the intestinal nematode parasite Trichuris muris, J Immunol, 175, 6713, 10.4049/jimmunol.175.10.6713

Gordon, 2003, Alternative activation of macrophages, Nat Rev Immunol, 3, 23, 10.1038/nri978

Bonecchi, 1998, Divergent effects of interleukin-4 and interferon-γon macrophage-derived chemokine production: an amplification circuit of polarized T helper 2 responses, Blood, 92, 2668, 10.1182/blood.V92.8.2668

Andrew, 1998, STCP-1 (MDC) CC chemokine acts specifically on chronically activated Th2 lymphocytes and is produced by monocytes on stimulation with Th2 cytokines IL-4 and IL-13, J Immunol, 161, 5027, 10.4049/jimmunol.161.9.5027

Kodelja, 1997, Differences in angiogenic potential of classically vs. alternatively activated macrophages, Immunobiology, 197, 478, 10.1016/S0171-2985(97)80080-0

Laroux, 2001, Immunological basis of inflammatory bowel disease: role of the microcirculation, Microcirculation, 8, 283, 10.1038/sj.mn.7800095

Kanai, 2001, Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease, Gastroenterology, 121, 875, 10.1053/gast.2001.28021

Banks, 2003, Chemokine expression in IBD Mucosal chemokine expression is unselectively increased in both ulcerative colitis and Crohn's disease, J Pathol, 199, 28, 10.1002/path.1245

Garside, 1999, Cytokines in experimental colitis, Clin Exp Immunol, 118, 337, 10.1046/j.1365-2249.1999.01088.x

Hausmann, 2001, Subtractive screening reveals up-regulation of NADPH oxidase expression in Crohn's disease intestinal macrophages, Clin Exp Immunol, 125, 48, 10.1046/j.1365-2249.2001.01567.x

Rutgeerts, 2006, Review article: Infliximab therapy for inflammatory bowel disease--seven years on, Aliment Pharmacol Ther, 23, 451, 10.1111/j.1365-2036.2006.02786.x

Baert, 1999, Tumor necrosis factor alpha antibody (infliximab) therapy profoundly down-regulates the inflammation in Crohn's ileocolitis, Gastroenterology, 116, 22, 10.1016/S0016-5085(99)70224-6

Popivanova, 2008, Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis, J Clin Invest, 118, 560

Corazza, 1999, Nonlymphocyte-derived tumor necrosis factor is required for induction of colitis in recombination activating gene (RAG)2−/− mice upon transfer of CD4+CD45RBhi T cells, J Exp Med, 190, 1479, 10.1084/jem.190.10.1479

Mundy, 2005, Citrobacter rodentium of mice and man, Cell Microbiol, 7, 1697, 10.1111/j.1462-5822.2005.00625.x

Watanabe, 2003, Elimination of local macrophages in intestine prevents chronic colitis in interleukin-10-deficient mice, Dig Dis Sci, 48, 408, 10.1023/A:1021960401290

Axelsson, 1996, Dextran sulfate sodium (DSS) induced experimental colitis in immunodeficient mice: effects in CD4+-cell depleted, athymic and NK-cell depleted SCID mice, Inflamm Res, 45, 181, 10.1007/BF02285159

Dieleman, 1994, Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice, Gastroenterology, 107, 1643, 10.1016/0016-5085(94)90803-6

Chen, 2004, Depletion of intestinal resident macrophages prevents ischaemia reperfusion injury in gut, Gut, 53, 1772, 10.1136/gut.2003.034868

Menzel, 2006, Cathepsins B L and D in inflammatory bowel disease macrophages and potential therapeutic effects of cathepsin inhibition in vivo, Clin Exp Immunol, 146, 169, 10.1111/j.1365-2249.2006.03188.x

Keshavarzian, 2003, Increases in free radicals and cytoskeletal protein oxidation and nitration in the colon of patients with inflammatory bowel disease, Gut, 52, 720, 10.1136/gut.52.5.720

Theiss, 2005, Tumor necrosis factor (TNF) α increases collagen accumulation and proliferation in intestinal myofibroblasts via TNF receptor 2, J Biol Chem, 280, 36099, 10.1074/jbc.M505291200

Demetter, 2005, Colon mucosa of patients both with spondyloarthritis and Crohn's disease is enriched with macrophages expressing the scavenger receptor CD163, Ann Rheum Dis, 64, 321, 10.1136/ard.2003.018382

Mahida, 1988, Characterization of antigen-presenting activity of intestinal mononuclear cells isolated from normal and inflammatory bowel disease colon and ileum, Immunology, 65, 543

Rogler, 1999, T-cell co-stimulatory molecules are upregulated on intestinal macrophages from inflammatory bowel disease mucosa, Eur J Gastroenterol Hepatol, 11, 1105, 10.1097/00042737-199910000-00006

Rugtveit, 1997, Cytokine profiles differ in newly recruited and resident subsets of mucosal macrophages from inflammatory bowel disease, Gastroenterology, 112, 1493, 10.1016/S0016-5085(97)70030-1

Rugtveit, 1995, Respiratory burst of intestinal macrophages in inflammatory bowel disease is mainly caused by CD14+L1+ monocyte derived cells, Gut, 37, 367, 10.1136/gut.37.3.367

Rugtveit, 1997, Differential distribution of B7 1 (CD80) and B7. 2 (CD86) costimulatory molecules on mucosal macrophage subsets in human inflammatory bowel disease (IBD), Clin Exp Immunol, 110, 104, 10.1111/j.1365-2249.1997.507-ce1404.x

Tokuyama, 2005, The simultaneous blockade of chemokine receptors CCR2 CCR5 and CXCR3 by a non-peptide chemokine receptor antagonist protects mice from dextran sodium sulfate-mediated colitis, Int Immunol, 17, 1023, 10.1093/intimm/dxh284

Takeuchi, 2002, Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins, J Immunol, 169, 10, 10.4049/jimmunol.169.1.10

Wyllie, 2000, Evidence for an accessory protein function for Toll-like receptor 1 in anti-bacterial responses, J Immunol, 165, 7125, 10.4049/jimmunol.165.12.7125

Aliprantis, 1999, Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2, Science, 285, 736, 10.1126/science.285.5428.736

Alexopoulou, 2001, Recognition of double-stranded RNA and activation of NFκB by Toll-like receptor 3, Nature, 413, 732, 10.1038/35099560

Poltorak, 1998, Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene, Science, 282, 2085, 10.1126/science.282.5396.2085

Jiang, 2000, Lipopolysaccharide induces physical proximity between CD14 and toll-like receptor 4 (TLR4) prior to nuclear translocation of NFκB, J Immunol, 165, 3541, 10.4049/jimmunol.165.7.3541

Hayashi, 2001, The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5, Nature, 410, 1099, 10.1038/35074106

Means, 2003, The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells, J Immunol, 170, 5165, 10.4049/jimmunol.170.10.5165

Applequist, 2002, Variable expression of Toll-like receptor in murine innate and adaptive immune cell lines, Int Immunol, 14, 1065, 10.1093/intimm/dxf069

Takeuchi, 2001, Discrimination of bacterial lipoproteins by Toll-like receptor 6, Int Immunol, 13, 933, 10.1093/intimm/13.7.933

Ozinsky, 2000, The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors, Proc Natl Acad Sci USA, 97, 13766, 10.1073/pnas.250476497

Diebold, 2004, Reis e Sousa C Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA, Science, 303, 1529, 10.1126/science.1093616

Heil, 2004, Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8, Science, 303, 1526, 10.1126/science.1093620

Hemmi, 2002, Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway, Nat Immunol, 3, 196, 10.1038/ni758

Hemmi, 2000, A Toll-like receptor recognizes bacterial DNA, Nature, 408, 740, 10.1038/35047123