Mucoepidermoid carcinoma of the palate in a 5-year-old girl: case report and literature review
Tóm tắt
Minor salivary gland tumors in children are uncommon. However, despite the low overall incidence, there is a high incidence of malignancy in these young patients which is reported to be above 50 %, with mucoepidermoid carcinoma (MEC) predominating. We hope that this case report will contribute to the enlightenment of the behavior and prognosis of pediatric MEC of palatal minor salivary gland tumors. A 5-year-old girl was admitted to our center with a histologically confirmed MEC of the left hard palate. Primary incision for drainage of a supposed abscess and secondary biopsy had been performed elsewhere 14 days before. After further workup, we excised the tumor and the adjacent bone; clear margins of 10 mm were revealed. Adjuvant therapy was not necessary. The defect was allowed to undergo secondary wound healing. As of the 1-year follow-up, there had been no recurrences. For differential diagnosis, MEC should be considered in cases of soft, slow-growing, painless, pale bluish-purple lumps of the palate even in young patients. Especially for nonresponders to initial treatment, early biopsy is recommended for histological confirmation or exclusion of a minor salivary gland tumor.
Tài liệu tham khảo
Eveson JW, Cawson RA (1985) Tumours of the minor (oropharyngeal) salivary glands: a demographic study of 336 cases. J Oral Pathol 14:500–509
Waldron CA, El-Mofty SK, Gnepp DR (1988) Tumors of the intraoral minor salivary glands: a demographic and histologic study of 426 cases. Oral Surg Oral Med Oral Pathol 66:323–333
Yu GY, Li ZL, Ma DQ, Zhang Y (2002) Diagnosis and treatment of epithelial salivary gland tumours in children and adolescents. Br J Oral Maxillofac Surg 40:389–3926
Fonseca I, Martins AG, Soares J (1991) Epithelial salivary gland tumors of children and adolescents in southern Portugal: a clinicopathologic study of twenty-four cases. Oral Surg Oral Med Oral Pathol 72:696–701
Ritwik P, Cordell KG, Brannon RB (2012) Minor salivary gland mucoepidermoid carcinoma in children and adolescents: a case series and review of the literature. J Med Case Rep 6:182
Yih WY, Kratochvil FJ, Stewart JC (2005) Intraoral minor salivary gland neoplasms: review of 213 cases. J Oral Maxillofac Surg 63:805–810
Mehta D, Willging JP (2006) Pediatric salivary gland lesions. Semin Pediatr Surg 15:76–84
Luna MA, Batsakis JG, el-Naggar AK (1991) Salivary gland tumors in children. Ann Otol Rhinol Laryngol 100:869–871
Wittekind C, Asamura H, Sobin LH (2013) TNM atlas, 6th edn. Wiley, New York
Sousa BF, Etges A, Corrêa L, Mesquita RA, de Araújo NS (2002) Pediatric oral lesions: a 15-year review from São Paulo, Brazil. J Clin Pediatr Dent 26:413–418
Caccamese JF, Ord RA (2002) Paediatric mucoepidermoid carcinoma of the palate. Int J Oral Maxillofac Surg 31:136–139
Melrose RJ, Abrams AM, Howell FV (1973) Mucoepidermoid tumors of the intraoral minor salivary glands: a clinicopathologic study of 54 cases. J Oral Pathol 2:314–325
Flaitz CM (2000) Mucoepidermoid carcinoma of the palate in a child. Pediatr Dent 22:292–293
Conley J, Tinsley PP (1985) Treatment and prognosis of mucoepidermoid carcinoma in the pediatric age group. Arch Otolaryngol 111:322–324
Olsen KD, Devine KD, Weiland LH (1981) Mucoepidermoid carcinoma of the oral cavity. Otolaryngol Head Neck Surg 89:783–791
April MM, Brodsky LS, Cunningham MJ, Harari PM, Harrison L, Poje CP (1997) Mucoepidermoid carcinoma in a 10-year-old girl. Head Neck 19:431–435
Schneider AB, Lubin J, Ron E, Abrahams C, Stovall M, Goel A, Shore-Freedman E, Gierlowski TC (1998) Salivary gland tumors after childhood radiation treatment for benign conditions of the head and neck: dose–response relationship. Radiat Res 149:625–630
Védrine PO, Coffinet L, Temam S, Montagne K, Lapeyre M, Oberlin O, Orbach D, Simon C, Sommelet D (2006) Head Neck 28:827–833
Hosokawa Y, Shirato H, Kagei K, Hashimoto S, Nishioka T, Tei K, Ono M, Ohmori K, Kaneko M, Miyasaka K, Nakamura M (1999) Role of radiotherapy for mucoepidermoid carcinoma of the salivary gland. Oral Oncol 35:105–111
Perez DE, Pires FR, Alves Fde A, Lopes MA, de Almeida OP, Kowalski LP (2008) Juvenile intraoral mucoepidermoid carcinoma. J Oral Maxillofac Surg 66:308–311