Mucoadhesive systems in oral drug delivery

Drug Discovery Today: Technologies - Tập 2 - Trang 83-87 - 2005
Andreas Bernkop-Schnürch1
1Department of Pharmaceutical Technology, Institute of Pharmacy, Leopold-Franzens-University Innsbruck, Innrain 52, Josef Möller Haus, 6020 Innsbruck, Austria

Tài liệu tham khảo

Hornof, 2003, Mucoadhesive ocular insert based on thiolated poly(acrylic acid): development and in vivo evaluation in humans, J. Control. Release, 89, 419, 10.1016/S0168-3659(03)00135-4 Tafaghodi, 2004, Evaluation of the clearance characteristics of various microspheres in the human nose by gamma-scintigraphy, Int. J. Pharm., 280, 125, 10.1016/j.ijpharm.2004.05.009 Bernkop-Schnürch, 2003, Intravaginal delivery: design, challenges and solutions, Am. J. Drug Deliv., 1, 241 Korbonits, 2004, A comparison of a novel testosterone bioadhesive buccal system, striant, with a testosterone adhesive patch in hypogonadal males, J. Clin. Endocrinol. Metab., 89, 2039, 10.1210/jc.2003-030319 Akiyama, 1999, Novel formulation approaches to oral mucoadhesive drug delivery systems, 177 Khosla, 1987, The effect of polycarbophil on the gastric emptying of pellets, J. Pharm. Pharmacol., 39, 47, 10.1111/j.2042-7158.1987.tb07161.x Harris, 1990, GI transit of potential bioadhesive formulations in man: A scintigraphic study, J. Control. Release, 12, 45, 10.1016/0168-3659(90)90182-S Schipper, 1997, Chitosans as absorption enhancers for poorly absorbable drugs. 2: Mechanism of absorption enhancement, Pharm. Res., 14, 923, 10.1023/A:1012160102740 Lueßen, 1996, Mucoadhesive polymers in peroral peptide drug delivery. V. Effect of poly(acrylates) on the enzymatic degradation of peptide drugs by intestinal brush border membrane vesicles, Int. J. Pharm., 141, 39, 10.1016/0378-5173(96)04613-3 Bernkop-Schnürch, 2002, Mucoadhesive polymers, 147 Hassan, 1990, A simple rheological method for the in vitro assessment of mucin–polymer bioadhesive bond strength, Pharm. Res., 7, 491, 10.1023/A:1015812615635 Leitner, 2003, Thiolated polymers: evidence for the formation of disulphide bonds with mucus glycoproteins, Eur. J. Pharm. Biopharm., 56, 207, 10.1016/S0939-6411(03)00061-4 Bernkop-Schnürch, 2003, Thiolated polymers – thiomers: synthesis and in vitro evaluation of chitosan–2-iminothiolane conjugates, Int. J. Pharm., 260, 229, 10.1016/S0378-5173(03)00271-0 Bernkop-Schnürch, 2000, Development of controlled drug release systems based on polymer–cysteine conjugates, J. Control. Release, 66, 39, 10.1016/S0168-3659(99)00256-4 Allen, A. et al. (1984) Mucus, mucosa. In Ciba Foundation Symposium 109 (Nugent, J. and O’Connor, M., eds) Kast, 2003, Development and in vivo evaluation of an oral delivery system for low molecular weight heparin based on thiolated polycarbophil, Pharm. Res., 20, 931, 10.1023/A:1023803706746 Caliceti, 2004, Development and in vivo evaluation of an oral insulin–PEG delivery system, Eur. J. Pharm. Sci., 22, 315, 10.1016/j.ejps.2004.03.015 Guggi, 2003, Systemic peptide delivery via the stomach: in vivo evaluation of an oral dosage form for salmon calcitonin, J. Control. Release, 92, 125, 10.1016/S0168-3659(03)00299-2 Bernkop-Schnürch, A. The use of thiolated polymers as carrier matrix in oral peptide delivery – proof of concept. J. Control. Release (in press) Albrecht, K. et al. In vitro evaluation of parameters influencing the mucoadhesive properties of thiomer particles. Proceedings of the Controlled Release Society Annual Meeting #688 Coupe, 1991, Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects, Pharm. Res., 8, 360, 10.1023/A:1015849700421 Zili, 2005, Preparation and characterization of poly-varepsilon–caprolactone nanoparticles containing griseofulvin, Int. J. Pharm., 294, 261, 10.1016/j.ijpharm.2005.01.020 Mathiowitz, 1997, Biologically erodable microspheres as potential oral drug delivery systems, Nature, 386, 410, 10.1038/386410a0 Bernkop-Schnürch, 2003, Preparation and in vitro characterization of poly(acrylic acid)–cysteine microparticles, J. Control. Release, 93, 29, 10.1016/S0168-3659(03)00339-0 Bernkop-Schnürch, A. et al. Thiomers: preparation and in vitro evaluation of mucoadhesive particulate delivery systems. Proceedings of the Controlled Release Society Annual Meeting #357 Marschütz, 2002, Thiolated polymers: advance in mucoadhesion by use of in situ crosslinking poly(acrylic acid)–cysteine conjugates, Eur. J. Pharm. Sci., 15, 387, 10.1016/S0928-0987(02)00025-8 Bernkop-Schnürch, 2004, Synthesis and in vitro characterization of a poly(acrylic acid)–homocysteine conjugate, Drug Dev. Ind. Pharm., 30, 1, 10.1081/DDC-120027505 Kast, 2001, Thiolated polymers – thiomers: development and in vitro evaluation of chitosan–thioglycolic acid conjugates, Biomaterials, 22, 2345, 10.1016/S0142-9612(00)00421-X Kafedjiiski, 2005, Synthesis and in vitro evaluation of a novel thiolated chitosan, Biomaterials, 26, 819, 10.1016/j.biomaterials.2004.03.011 Bernkop-Schnürch, 2001, Improvement in the mucoadhesive properties of alginate by the covalent attachment of cysteine, J. Control. Release, 71, 277, 10.1016/S0168-3659(01)00227-9 Bernkop-Schnürch, 2004, Preparation and characterisation of thiolated poly(methacrylic acid)–starch compositions, Eur. J. Pharm. Biopharm., 57, 219, 10.1016/j.ejpb.2002.11.001 Bernkop-Schnürch, 2000, Synthesis and characterisation of mucoadhesive thiolated polymers, Int. J. Pharm., 194, 239, 10.1016/S0378-5173(99)00387-7 Carino, 1999, Oral insulin delivery, Adv. Drug Deliv. Rev., 35, 249, 10.1016/S0169-409X(98)00075-1 Santos, 2003, Evaluation of anhydride oligomers within polymer microsphere blends and their impact on bioadhesion and drug delivery in vitro, Biomaterials, 24, 3571, 10.1016/S0142-9612(03)00219-9