Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia

Cancer Cell - Tập 36 - Trang 84-99.e8 - 2019
Irène Baccelli1, Yves Gareau1,2, Bernhard Lehnertz1, Stéphane Gingras1,2, Jean-François Spinella1, Sophie Corneau1, Nadine Mayotte1, Simon Girard1, Mélanie Frechette1, Valérie Blouin-Chagnon1, Koryne Leveillé1, Isabel Boivin1, Tara MacRae1, Jana Krosl1, Clarisse Thiollier1, Vincent-Philippe Lavallée1, Evgeny Kanshin1, Thierry Bertomeu1, Jasmin Coulombe-Huntington1, Corinne St-Denis1
1The Leucegene Project at Institute for Research in Immunology (IRIC) and Cancer, Université de Montréal, 2950 Chemin de Polytechnique Pavillon, Marcelle-Coutu, Montréal, QC H3T 1J4, Canada
2Department of Chemistry, Université de Montréal Pavillon Roger-Gaudry, 2900 Boulevard Édouard-Montpetit, Montréal, QC H3C 3J7, Canada

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