Mortality in chronic kidney disease patients with COVID-19: a systematic review and meta-analysis

Springer Science and Business Media LLC - 2021
Ruyi Cai1, Jinshi Zhang1, Yifan Zhu2, Lin Liu2, Yueming Liu2, Qiang He2
1School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang, 310018, People’s Republic of China
2Department of Nephrology, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, 310014, People’s Republic of China

Tóm tắt

AbstractAt the beginning of 2020, the outbreak of coronavirus disease 2019 (COVID-19) led to a worldwide pandemic and mass panic. The number of infected people has been increasing exponentially since, and the mortality rate has also been concomitantly increasing. At present, no study has summarized the mortality risk of COVID-19 in patients with chronic kidney disease (CKD). Therefore, the aim of the present study was to conduct a literature review and meta-analysis to understand the frequency of mortality among CKD patients infected with COVID-19. A comprehensive systematic search was conducted on the PubMed, Embase, and Cochrane databases to find articles published until May 15, 2020. Study quality was assessed using a modified version of the Newcastle–Ottawa Scale. After careful screening based on the inclusion and exclusion criteria, 3,867,367 patients from 12 studies were included. The mortality rate was significantly higher among CKD patients with COVID-19 infection than among CKD patients without COVID-19 infection, as indicated by a pooled OR of 5.81 (95% CI 3.78–8.94, P < 0.00001, I2 = 30%). The patients were then stratified into ≥ 70 and < 70 years, and subgroup analysis revealed that among CKD patients with COVID-19 infection, the mortality rate was higher in the < 70 years group (OR 8.69, 95% CI 7.56–9.97, P < 0.0001) than in the ≥ 70 years group (OR 2.44, 95% CI 0.75–6.63, P = 0.15). Thus, COVID-19 patients with CKD have a high mortality risk and require a comprehensive multidisciplinary management strategy.

Từ khóa


Tài liệu tham khảo

Wang D, Hu B, Hu C et al (2020) Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China [J]. JAMA 323(11):1061

Phelan AL, Katz R, Gostin LO (2020) The Novel Coronavirus Originating in Wuhan, China: Challenges for Global Health Governance [J]. JAMA 323(8):709–710

Chen NS, Zhou M, Dong X et al (2020) Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study [J]. Lancet 395(10223):507–513

Huang CL, Wang YM, Li XW et al (2020) Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China [J]. Lancet 395(10223):497–506

Gandhi RT, Lynch JB, Rio CD (2020) Mild or Moderate Covid-19 [J]. N Engl J Med 383(18):1757–1766

Berlin DA, Solomon CG, Gulick RM et al (2020) Severe Covid-19 [J]. New England Journal of Medicine

Singh AK, Gillies CL, Singh R et al (2020) Prevalence of comorbidities and their association with mortality in patients with COVID-19: a systematic review and meta-analysis [J]. Diabetes Obes Metab 22(10):1915–1924

Sarnak MJ, Jaber BL (2001) Pulmonary infectious mortality among patients with end-stage renal disease [J]. Chest 120:1883–1887

Henry BM, Lippi G (2020) Chronic kidney disease is associated with severe coronavirus disease 2019 (COVID-19) infection [J]. Int Urol Nephrol 52(6):1193–1194

Cheng Y, Luo R, Wang K et al (2020) Kidney disease is associated with in-hospital death of patients with COVID-19 [J]. Kidney Int 97(5):829–838

Liberati A, Altman DG, Tetzlaff J et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration [J]. BMJ 339:b2700

Wells GA, Shea B, O'Connell D et al (2014) The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses [J]. Ottawa Health Research Institute Web site

Zhou F, Yu T, Du R et al (2020) Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study [J]. Lancet 395(10229):1054–1062

Yan Y, Yang Y, Wang F et al (2020) Clinical characteristics and outcomes of patients with severe covid-19 with diabetes [J]. BMJ Open Diabetes Res Care 8(1):e001343

Wang L, He W, Yu X et al (2020) Coronavirus disease 2019 in elderly patients: characteristics and prognostic factors based on 4-week follow-up [J]. J Infect 80(6):639–645

Wang D, Yin Y, Hu C et al (2020) Clinical course and outcome of 107 patients infected with the novel coronavirus, SARS-CoV-2, discharged from two hospitals in Wuhan, China [J]. Crit Care 24(1):188

Shi S, Qin M, Cai Y et al (2020) Characteristics and clinical significance of myocardial injury in patients with severe coronavirus disease 2019 [J]. Eur Heart J 41(22):2070–2079

Shi Q, Zhang X, Jiang F et al (2020) Clinical characteristics and risk factors for mortality of COVID-19 patients with diabetes in wuhan, China: a two-center, retrospective study [J]. Diabetes Care 43(7):1382–1391

Ruan Q, Yang K, Wang M et al (2020) Correction to: clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China [J]. Intensive Care Med 46(6):1294–1297

Nikpouraghdam M, Farahani AJ, Alishiri G et al (2020) Epidemiological characteristics of coronavirus disease 2019 (COVID-19) patients in IRAN: a single center study [J]. J Clin Virol 127:104378

Chen T, Wu D, Chen H et al (2020) Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study [J]. BMJ 368:m1091

Chen T, Dai Z, Mo P et al (2020) Clinical characteristics and outcomes of older patients with coronavirus disease 2019 (COVID-19) in Wuhan, China (2019): a single-centered, retrospective study [J]. J Gerontol A Biol Sci Med Sci 75(9):1788–1795

Cao J, Tu WJ, Cheng W et al (2020) Clinical features and short-term outcomes of 102 patients with corona virus disease 2019 in Wuhan, China [J]. Clin Infect Dis 71(15):748–755

Banerjee A, Pasea L, Harris S et al (2020) Estimating excess 1-year mortality associated with the COVID-19 pandemic according to underlying conditions and age: a population-based cohort study [J]. Lancet 395(10238):1715–1725

Bikbov B, Purcell CA, Levey AS et al (2020) Global, regional, and national burden of chronic kidney disease, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 [J]. Lancet 395(10225):709–733

Kessler M, Hoen B, Mayeux D et al (1993) Bacteremia in patients on chronic hemodialysis [J]. Nephron 64(1):95–100

Betjes MG (2013) Immune cell dysfunction and inflammation in end-stage renal disease [J]. Nat Rev Nephrol 9(5):255–265

Lee JY, Kim HA, Huh K et al (2020) Risk factors for mortality and respiratory support in elderly patients hospitalized with COVID-19 in Korea [J]. J Korean Med Sci 35(23):e223

Li R, Li SR, Du XB et al (2020) Clinical observations in the very elderly patients with COVID-19 in Wuhan [J]. Geriatr Gerontol Int 20(7):709–714

Thông tin
Thông tin xuất bản

Springer Science and Business Media LLC

Thông tin tác giả