Morphological Assessment and Biomarkers of Low-Grade, Chronic Intestinal Inflammation in Production Animals
Tóm tắt
Từ khóa
Tài liệu tham khảo
Choct, 2009, Managing Gut Health through Nutrition, Br. Poult. Sci., 50, 9, 10.1080/00071660802538632
Svihus, 2014, Function of the Digestive System, J. Appl. Poult. Res., 23, 306, 10.3382/japr.2014-00937
Celi, 2019, Biomarkers of Gastrointestinal Functionality in Animal Nutrition and Health, Anim. Feed Sci. Technol., 250, 9, 10.1016/j.anifeedsci.2018.07.012
Liu, H.Y., Dicksved, J., Rakhshandeh, A., and Cai, D. (2021). Integrated Role of Nutrition and Digestive Physiology for Animal Health. Front. Vet. Sci., 8.
Abraham, 2011, Interactions between the Host Innate Immune System and Microbes in Inflammatory Bowel Disease, Gastroenterology, 140, 1729, 10.1053/j.gastro.2011.02.012
Nicholson, 2012, Host-Gut Microbiota Metabolic Interactions, Science (1979), 336, 1262
Kinnebrew, 2012, Innate Immune Signaling in Defense against Intestinal Microbes, Immunol. Rev., 245, 113, 10.1111/j.1600-065X.2011.01081.x
Alexander, 2020, Deconstructing Mechanisms of Diet-Microbiome-Immune Interactions, Immunity, 53, 264, 10.1016/j.immuni.2020.07.015
Kogut, 2019, The Effect of Microbiome Modulation on the Intestinal Health of Poultry, Anim. Feed Sci. Technol., 250, 32, 10.1016/j.anifeedsci.2018.10.008
Nobs, 2020, Nutrition Regulates Innate Immunity in Health and Disease, Annu. Rev. Nutr., 40, 189, 10.1146/annurev-nutr-120919-094440
Kogut, M.H., and Arsenault, R.J. (2015). A Role for the Non-Canonical Wnt-β-Catenin and TGF-β Signaling Pathways in the Induction of Tolerance during the Establishment of a Salmonella Enterica Serovar Enteritidis Persistent Cecal Infection in Chickens. Front. Vet. Sci., 2.
Lee, M.D., Ipharraguerre, I.R., Arsenault, R.J., Lyte, M., Lyte, J.M., Humphrey, B., Angel, R., and Korver, D.R. (2022). Informal Nutrition Symposium: Leveraging the Microbiome (and the Metabolome) for Poultry Production. Poult. Sci., 101.
Makowski, 2020, Immunometabolism: From Basic Mechanisms to Translation, Immunol. Rev., 295, 5, 10.1111/imr.12858
Michaudel, 2020, The Gut Microbiota at the Service of Immunometabolism, Cell Metab., 32, 514, 10.1016/j.cmet.2020.09.004
Goo, 2019, Effect of Stocking Density and Sex on Growth Performance, Meat Quality, and Intestinal Barrier Function in Broiler Chickens, Poult. Sci., 98, 1153, 10.3382/ps/pey491
Reisinger, N., Emsenhuber, C., Doupovec, B., Mayer, E., Schatzmayr, G., Nagl, V., and Grenier, B. (2020). Endotoxin Translocation and Gut Inflammation Are Increased in Broiler Chickens Receiving an Oral Lipopolysaccharide (LPS) Bolus during Heat Stress. Toxins, 12.
Goo, D., Kim, J.H., Park, G.H., Reyes, J.B.D., and Kil, D.Y. (2019). Effect of Heat Stress and Stocking Density on Growth Performance, Breast Meat Quality, and Intestinal Barrier Function in Broiler Chickens. Animals, 9.
Goossens, E., Debyser, G., Callens, C., de Gussem, M., Dedeurwaerder, A., Devreese, B., Haesebrouck, F., Flügel, M., Pelzer, S., and Thiemann, F. (2018). Elevated Faecal Ovotransferrin Concentrations Are Indicative for Intestinal Barrier Failure in Broiler Chickens. Vet. Res., 49.
Lee, 2007, Hypoxia, Drug Therapy and Toxicity, Pharmacol. Ther., 113, 229, 10.1016/j.pharmthera.2006.08.001
Taylor, 2007, Hypoxia and Gastrointestinal Disease, J. Mol. Med., 85, 1295, 10.1007/s00109-007-0277-z
2019, Holistic View of Intestinal Health in Poultry, Anim. Feed Sci. Technol., 250, 1, 10.1016/j.anifeedsci.2019.01.009
Tabler, T.W., Greene, E.S., Orlowski, S.K., Hiltz, J.Z., Anthony, N.B., and Dridi, S. (2020). Intestinal Barrier Integrity in Heat-Stressed Modern Broilers and Their Ancestor Wild Jungle Fowl. Front. Vet. Sci., 7.
Kogut, 2018, Inflammatory Phenotypes in the Intestine of Poultry: Not All Inflammation Is Created Equal, Poult. Sci., 97, 2339, 10.3382/ps/pey087
Broom, 2019, Deciphering Desirable Immune Responses from Disease Models with Resistant and Susceptible Chickens, Poult. Sci., 98, 1634, 10.3382/ps/pey535
Lauridsen, 2019, From Oxidative Stress to Inflammation: Redox Balance and Immune System, Poult. Sci., 98, 4240, 10.3382/ps/pey407
Roseth, 1997, Assessment of Disease Activity in Ulcerative Colitis by Faecal Calprotectin, a Novel Granulocyte Marker Protein, Digestion, 58, 176, 10.1159/000201441
Rychlik, I., Elsheimer-Matulova, M., and Kyrova, K. (2014). Gene Expression in the Chicken Caecum in Response to Infections with Non-Typhoid Salmonella. Vet. Res., 45.
He, 2019, Zinc Source Influences the Gene Expression of Zinc Transporters in Jejunum and Cecal Tonsils during Broiler Challenge with Eimeria Maxima and Clostridium Perfringens, Poult. Sci., 98, 1146, 10.3382/ps/pey484
Bento, 2012, Evaluation of Chemical Mediators and Cellular Response during Acute and Chronic Gut Inflammatory Response Induced by Dextran Sodium Sulfate in Mice, Biochem. Pharmacol., 84, 1459, 10.1016/j.bcp.2012.09.007
Lochmiller, 2000, Trade-Offs in Evolutionary Immunology: Just What Is the Cost of Immunity?, Oikos, 88, 87, 10.1034/j.1600-0706.2000.880110.x
Corzo, 2007, Dietary Threonine Needs for Growth and Immunity of Broilers Raised under Different Litter Conditions, J. Appl. Poult. Res., 16, 574, 10.3382/japr.2007-00046
Jiang, 2010, Net Effect of an Acute Phase Response-Partial Alleviation with Probiotic Supplementation, Poult. Sci., 89, 28, 10.3382/ps.2009-00464
Klasing, 1987, Immunologically Mediated Growth Depression in Chicks: Influence of Feed Intake, Corticosterone and Interleukin-1, J. Nutr., 117, 1629, 10.1093/jn/117.9.1629
Medzhitov, 2021, The Spectrum of Inflammatory Responses, Science (1979), 374, 1070
Dal Pont, G.C., Belote, B.L., Lee, A., Bortoluzzi, C., Eyng, C., Sevastiyanova, M., Khadem, A., Santin, E., Farnell, Y.Z., and Gougoulias, C. (2021). Novel Models for Chronic Intestinal Inflammation in Chickens: Intestinal Inflammation Pattern and Biomarkers. Front. Immunol., 12.
Caspary, 1992, Physiology and Pathophysiology of Intestinal Absorption, Am. J. Clin. Nutr., 55, 299, 10.1093/ajcn/55.1.299s
Awad, 2009, Effects of Dietary Inclusion of Probiotic and Synbiotic on Growth Performance, Organ Weights, and Intestinal Histomorphology of Broiler Chickens, Poult. Sci., 88, 49, 10.3382/ps.2008-00244
Kraieski, 2017, Effect of Aflatoxin Experimental Ingestion and Eimeira Vaccine Challenges on Intestinal Histopathology and Immune Cellular Dynamic of Broilers: Applying an Intestinal Health Index, Poult. Sci., 96, 1078, 10.3382/ps/pew397
Belote, 2018, Histological Parameters to Evaluate Intestinal Health on Broilers Challenged with Eimeria and C Lostridium Perfringens with or without Enramycin as Growth Promoter, Poult. Sci., 97, 2287, 10.3382/ps/pey064
Belote, B.L., Soares, I., Tujimoto-Silva, A., Sanches, A.W.D., Kraieski, A.L., and Santin, E. (2019). Applying I See inside Histological Methodology to Evaluate Gut Health in Broilers Challenged with Eimeria. Vet. Parasitol. X, 1.
Belote, B.L., Soares, I., Tujimoto-Silva, A., Tirado, A.G.C., Martins, C.M., Carvalho, B., Gonzalez-Esquerra, R., Rangel, L.F.S., and Santin, E. (2021). Field Evaluation of Feeding Spray-Dried Plasma in the Starter Period on Final Performance and Overall Health of Broilers. Poult. Sci., 100.
Sanches, A.W.D., Belote, B.L., Hümmelgen, P., Heemann, A.C.W., Soares, I., Tujimoto-Silva, A., Tirado, A.G.C., Cunha, A.F., and Santin, E. (2020). Basal and Infectious Enteritis in Broilers Under the I See Inside Methodology: A Chronological Evaluation. Front. Vet. Sci., 6.
Santin, 2003, Evaluation of the Efficacy of Saccharomyces Cerevisiae Cell Wall to Ameliorate the Toxic Effects of Aflatoxin in Broilers, Int. J. Poult. Sci., 2, 341, 10.3923/ijps.2003.341.344
Ortatatli, 2005, Evaluation of Pathological Changes in Broilers during Chronic Aflatoxin (50 and 100 Ppb) and Clinoptilolite Exposure, Res. Vet. Sci., 78, 61, 10.1016/j.rvsc.2004.06.006
Ducatelle, R., Goossens, E., de Meyer, F., Eeckhaut, V., Antonissen, G., Haesebrouck, F., and van Immerseel, F. (2018). Biomarkers for Monitoring Intestinal Health in Poultry: Present Status and Future Perspectives. Vet. Res., 49.
Wan, 1995, Role of Lipopolysaccharide (LPS), Interleukin-1, Interleukin-6, Tumor Necrosis Factor, and Dexamethasone in Regulation of LPS-Binding Protein Expression in Normal Hepatocytes and Hepatocytes from LPS-Treated Rats, Infect. Immun., 63, 2435, 10.1128/iai.63.7.2435-2442.1995
Read, 1993, Chylomicrons Enhance Endotoxin Excretion in Bile, Infect. Immun., 61, 3496, 10.1128/iai.61.8.3496-3502.1993
Berbee, 2005, Apolipoproteins Modulate the Inflammatory Response to Lipopolysaccharide, J. Endotoxin Res., 11, 97, 10.1177/09680519050110020501
Krasity, 2011, LBP/BPI Proteins and Their Relatives: Conservation over Evolution and Roles in Mutualism, Biochem. Soc. Trans., 39, 1039, 10.1042/BST0391039
Brokordt, 2020, Molecular Characterization and Expression Patterns of Two LPS Binding /Bactericidal Permeability-Increasing Proteins (LBP/BPIs) from the Scallop Argopecten Purpuratus, Fish Shellfish Immunol., 97, 12, 10.1016/j.fsi.2019.12.032
Weiss, 2003, Bactericidal/Permeability-Increasing Protein (BPI) and Lipopolysaccharide-Binding Protein (LBP): Structure, Function and Regulation in Host Defence against Gram-Negative Bacteria, Biochem. Soc. Trans., 31, 785, 10.1042/bst0310785
Roberts, 2021, Lipopolysaccharide Binding Protein Is Associated with CVD Risk in Older Adults, Aging Clin. Exp. Res., 33, 1651, 10.1007/s40520-020-01684-z
Kvidera, 2017, Intentionally Induced Intestinal Barrier Dysfunction Causes Inflammation, Affects Metabolism, and Reduces Productivity in Lactating Holstein Cows, J. Dairy Sci., 100, 4113, 10.3168/jds.2016-12349
Oliva, A., Aversano, L., de Angelis, M., Mascellino, M.T., Miele, M.C., Morelli, S., Battaglia, R., Iera, J., Bruno, G., and Corazziari, E.S. (2020). Persistent Systemic Microbial Translocation, Inflammation, and Intestinal Damage during Clostridioides Difficile Infection. Open Forum. Infect. Dis., 7.
Zhang, 2019, Superior Intestinal Integrity and Limited Microbial Translocation Are Associated with Lower Immune Activation in SIVmac239-Infected Northern Pig-Tailed Macaques (Macaca Leonina), Zool. Res., 40, 522, 10.24272/j.issn.2095-8137.2019.047
Cui, Y., Wang, C., Hao, Y., Gu, X., and Wang, H. (2019). Chronic Heat Stress Induces Acute Phase Responses and Serum Metabolome Changes in Finishing Pigs. Animals, 9.
Mayorga, 2018, Effects of Zinc Amino Acid Complex on Biomarkers of Gut Integrity and Metabolism during and Following Heat Stress or Feed Restriction in Pigs, J. Anim. Sci., 96, 4173, 10.1093/jas/sky293
Abuajamieh, 2018, The Effect of Recovery from Heat Stress on Circulating Bioenergetics and Inflammatory Biomarkers, J. Anim. Sci., 96, 4599
Pearce, 2014, Effects of Dairy Products on Intestinal Integrity in Heat-Stressed Pigs, Temperature, 1, 128, 10.4161/temp.29561
Opgenorth, 2021, The Effects of Zinc Amino Acid Complex on Biomarkers of Gut Integrity, Inflammation, and Metabolism in Heat-Stressed Ruminants, J. Dairy Sci., 104, 2410, 10.3168/jds.2020-18909
Kvidera, 2017, Characterizing Effects of Feed Restriction and Glucagon-like Peptide 2 Administration on Biomarkers of Inflammation and Intestinal Morphology, J. Dairy Sci., 100, 9402, 10.3168/jds.2017-13229
Mayorga, 2019, Effects of Dietary Chromium Propionate on Growth Performance, Metabolism, and Immune Biomarkers in Heat-Stressed Finishing Pigs, J. Anim. Sci., 97, 1185, 10.1093/jas/sky484
Horst, 2020, Evaluating Effects of Zinc Hydroxychloride on Biomarkers of Inflammation and Intestinal Integrity during Feed Restriction, J. Dairy Sci., 103, 11911, 10.3168/jds.2020-18860
Mayorga, E.J., Horst, E.A., Al-Qaisi, M., Goetz, B.M., Abeyta, M.A., Rodríguez-Jiménez, S., Lei, S., Acosta, J.A., Patience, J.F., and Serao, M.R. (2021). Effects of Continuously Infusing Glucose or Casein into the Terminal Ileum on Biomarkers of Metabolism, Inflammation, and Intestinal Morphology in Growing Pigs 1. J. Anim. Sci., 99.
Zhu, Y., Lin, X., Zhao, F., Shi, X., Li, H., Li, Y., Zhu, W., Xu, X., Lu, C., and Zhou, G. (2015). Meat, Dairy and Plant Proteins Alter Bacterial Composition of Rat Gut Bacteria. Sci. Rep., 5.
Petry, A.L., Huntley, N.F., Bedford, M.R., and Patience, J.F. (2020). Xylanase Increased the Energetic Contribution of Fiber and Improved the Oxidative Status, Gut Barrier Integrity, and Growth Performance of Growing Pigs Fed Insoluble Corn-Based Fiber 1. J. Anim. Sci., 98.
Bischoff, S.C., Kaden-Volynets, V., Filipe Rosa, L., Guseva, D., and Seethaler, B. (2021). Regulation of the Gut Barrier by Carbohydrates from Diet–Underlying Mechanisms and Possible Clinical Implications. Int. J. Med. Microbiol., 311.
Ahmad, 2019, Processed Meat Protein Promoted Inflammation and Hepatic Lipogenesis by Upregulating Nrf2/Keap1 Signaling Pathway in Glrx-Deficient Mice, J. Agric. Food Chem., 67, 8794, 10.1021/acs.jafc.9b03136
Panasevich, 2018, High-Fat, High-Fructose, High-Cholesterol Feeding Causes Severe NASH and Cecal Microbiota Dysbiosis in Juvenile Ossabaw Swine, Am. J. Physiol. Endocrinol. Metab., 314, 78, 10.1152/ajpendo.00015.2017
Roseth, 1992, Assessment of the Neutrophil Dominating Protein Calprotectin in Feces A Methodologic Study, Scand. J. Gastroenterol., 27, 793, 10.3109/00365529209011186
Jukic, 2021, Calprotectin: From Biomarker to Biological Function, Gut, 70, 1978, 10.1136/gutjnl-2021-324855
Heilmann, 2019, Mucosal Expression of S100A12 (Calgranulin C) and S100A8/A9 (Calprotectin) and Correlation with Serum and Fecal Concentrations in Dogs with Chronic Inflammatory Enteropathy, Vet. Immunol. Immunopathol., 211, 64, 10.1016/j.vetimm.2019.04.003
Chitayat, 2011, Nutrient Metal Sequestration by Calprotectin Inhibits Bacterial Superoxide Defense, Enhancing Neutrophil Killing of Staphylococcus aureus, Cell Host Microbe, 10, 158, 10.1016/j.chom.2011.07.004
Nakashige, 2017, Nickel Sequestration by the Host-Defense Protein Human Calprotectin, J. Am. Chem. Soc., 139, 8828, 10.1021/jacs.7b01212
Burcham, 2020, Identification of Zinc-Dependent Mechanisms Used by Group b Streptococcus to Overcome Calprotectin-Mediated Stress, mBio, 11, 1, 10.1128/mBio.02302-20
Schoepfer, 2008, Discriminating IBD from IBS: Comparison of the Test Performance of Fecal Markers, Blood Leukocytes, CRP, and IBD Antibodies, Inflamm. Bowel Dis., 14, 32, 10.1002/ibd.20275
Chaparro, 2018, Accuracy of Fecal Calprotectin for the Prediction of Endoscopic Activity in Patients with Inflammatory Bowel Disease, Dig. Liver Dis., 50, 353, 10.1016/j.dld.2017.12.022
Mosli, 2015, C-Reactive Protein, Fecal Calprotectin, and Stool Lactoferrin for Detection of Endoscopic Activity in Symptomatic Inflammatory Bowel Disease Patients: A Systematic Review and Meta-Analysis, Am. J. Gastroenterol., 110, 802, 10.1038/ajg.2015.120
Schoepfer, 2009, Ulcerative Colitis: Correlation of the Rachmilewitz Endoscopic Activity Index with Fecal Calprotectin, Clinical Activity, C-Reactive Protein, and Blood Leukocytes, Inflamm. Bowel Dis., 15, 1851, 10.1002/ibd.20986
Tibble, 2000, A Simple Method for Assessing Intestinal Inflammation in Crohn’s Disease, Gut, 47, 506, 10.1136/gut.47.4.506
Carroccio, 2003, Diagnostic Accuracy of Fecal Calprotectin Assay in Distinguishing Organic Causes of Chronic Diarrhea from Irritable Bowel Syndrome: A Prospective Study in Adults and Children, Clin. Chem., 49, 861, 10.1373/49.6.861
Heilmann, 2018, Association of Fecal Calprotectin Concentrations with Disease Severity, Response to Treatment, and Other Biomarkers in Dogs with Chronic Inflammatory Enteropathies, J. Vet. Intern. Med., 32, 679, 10.1111/jvim.15065
Grellet, 2013, Fecal Calprotectin Concentrations in Adult Dogs with Chronic Diarrhea, Am. J. Vet. Res., 74, 706, 10.2460/ajvr.74.5.706
Heilmann, 2012, Serum Calprotectin Concentrations in Dogs with Idiopathic Inflammatory Bowel Disease, Am. J. Vet. Res., 73, 1900, 10.2460/ajvr.73.12.1900
Barbosa, J.A., Rodrigues, L.A., Columbus, D.A., Aguirre, J.C.P., Harding, J.C.S., Cantarelli, V.S., and Costa, M.d.O. (2021). Experimental Infectious Challenge in Pigs Leads to Elevated Fecal Calprotectin Levels Following Colitis, but Not Enteritis. Porc. Health Manage., 7.
Boeckman, J.X., Sprayberry, S., Korn, A.M., Suchodolski, J.S., Paulk, C., Genovese, K., Rech, R.R., Giaretta, P.R., Blick, A.K., and Callaway, T. (2022). Effect of Chronic and Acute Enterotoxigenic E. coli Challenge on Growth Performance, Intestinal Inflammation, Microbiome, and Metabolome of Weaned Piglets. Sci. Rep., 12.
Fagerhol, 2005, The Effect of Intestinal Colonization of Germ-Free Pigs with Escherichia coli on Calprotectin Levels in Plasma, Intestinal and Bronchoalveolar Lavages, Immunobiology, 209, 681, 10.1016/j.imbio.2004.09.009
Bogere, 2019, Optimization of Fecal Calprotectin Assay for Pig Samples, J. Agric. Life Sci., 53, 93, 10.14397/jals.2019.53.1.93
Grellet, 2016, Influence of Breed Size, Age, Fecal Quality, and Enteropathogen Shedding on Fecal Calprotectin and Immunoglobulin A Concentrations in Puppies During the Weaning Period, J. Vet. Intern. Med., 30, 1056, 10.1111/jvim.14255
Xiao, D., Wang, Y., Liu, G., He, J., Qiu, W., Hu, X., Feng, Z., Ran, M., Nyachoti, C.M., and Kim, S.W. (2014). Effects of Chitosan on Intestinal Inflammation in Weaned Pigs Challenged by Enterotoxigenic Escherichia coli. PLoS ONE, 9.
Slinger, 2019, The Association between Faecal Host DNA or Faecal Calprotectin and Feed Efficiency in Pigs Fed Yeast-Enriched Protein Concentrate, Animal, 13, 2483, 10.1017/S1751731119000818
Mazgaj, R., Lipiński, P., Szudzik, M., Jończy, A., Kopeć, Z., Stankiewicz, A.M., Kamyczek, M., Swinkels, D., Żelazowska, B., and Starzyński, R.R. (2021). Comparative Evaluation of Sucrosomial Iron and Iron Oxide Nanoparticles as Oral Supplements in Iron Deficiency Anemia in Piglets. Int. J. Mol. Sci., 22.
Kristinsson, 1998, Fecal Calprotectin Concentration in Patients with Colorectal Carcinoma, Dis. Colon. Rectum., 41, 316, 10.1007/BF02237485
Bunn, 2001, Fecal Calprotectin as a Measure of Disease Activity in Childhood Inflammatory Bowel Disease, J. Pediatr. Gastroenterol. Nutr., 32, 171
Goetz, 2002, The Neutrophil Lipocalin NGAL Is a Bacteriostatic Agent That Interferes with Siderophore-Mediated Iron Acquisition Ation, Olfaction, Pheromone Transport, Prostaglandin Synthesis, Modulation of Cell Growth and Metabolism, Regulation of the Immune Response, Tissue Development, and Animal Behavior. However, Some of These Functional Assignments Have Been Made on Very Indirect or Circum, Mol. Cell, 10, 1033, 10.1016/S1097-2765(02)00708-6
Xiao, 2017, Lipocalin 2: An Emerging Player in Iron Homeostasis and Inflammation, Annu. Rev. Nutr., 37, 103, 10.1146/annurev-nutr-071816-064559
Moschen, 2017, Lipocalin-2: A Master Mediator of Intestinal and Metabolic Inflammation, Trends Endocrinol. Metab., 28, 388, 10.1016/j.tem.2017.01.003
Li, 2020, Lipocalin-2—The Myth of Its Expression and Function, Basic Clin. Pharmacol. Toxicol., 127, 142, 10.1111/bcpt.13332
Makris, 2012, Neurophil Gelatinase-Associated Lipocalin as a New Biomarker in Laboratory Medicine, Clin. Chem. Lab. Med., 50, 1519, 10.1515/cclm-2012-0227
Playford, 2006, Effects of Mouse and Human Lipocalin Homologues 24p3/Lcn2 and Neutrophil Gelatinase-Associated Lipocalin on Gastrointestinal Mucosal Integrity and Repair, Gastroenterology, 131, 809, 10.1053/j.gastro.2006.05.051
Raffatellu, 2009, Lipocalin-2 Resistance Confers an Advantage to Salmonella Enterica Serotype Typhimurium for Growth and Survival in the Inflamed Intestine, Cell Host Microbe, 5, 476, 10.1016/j.chom.2009.03.011
Zollner, 2021, Faecal Biomarkers in Inflammatory Bowel Diseases: Calprotectin versus Lipocalin-2-A Comparative Study, J. Crohns Colitis, 15, 43, 10.1093/ecco-jcc/jjaa124
Thorsvik, 2017, Fecal Neutrophil Gelatinase-Associated Lipocalin as a Biomarker for Inflammatory Bowel Disease, J. Gastroenterol. Hepatol., 32, 128, 10.1111/jgh.13598
Chassaing, B., Srinivasan, G., Delgado, M.A., Young, A.N., Gewirtz, A.T., and Vijay-Kumar, M. (2012). Fecal Lipocalin 2, a Sensitive and Broadly Dynamic Non-Invasive Biomarker for Intestinal Inflammation. PLoS ONE, 7.
Nielsen, 1999, Rectal Dialysate and Fecal Concentrations of Neutrophil Gelatinase-Associated Lipocalin, Interleukin-8, and Tumor Necrosis Factor-in Ulcerative Colitis, Am. J. Gastroentherology, 94, 2923, 10.1111/j.1572-0241.1999.01439.x
Bakke, 2021, Mucosal and Faecal Neutrophil Gelatinase-Associated Lipocalin as Potential Biomarkers for Collagenous Colitis, J. Gastroenterol., 56, 914, 10.1007/s00535-021-01814-y
Thorsvik, 2018, Expression of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in the Gut in Crohn’s Disease, Cell Tissue Res., 374, 339, 10.1007/s00441-018-2860-8
Wang, Y., Yang, Z., Zhou, Y., Tan, J., Sun, H., Sun, D., Mu, Y., Peng, J., and Wei, H. (2022). Effects of Different Amino Acid Levels and a Carvacrol–Thymol Blend on Growth Performance and Intestinal Health of Weaned Pigs. J. Anim. Sci. Biotechnol., 13.
Cheng, C., Wei, H., Xu, C., Xie, X., Jiang, S., and Peng, J. (2018). Maternal Soluble Fiber Diet during Pregnancy Changes the Intestinal Microbiota, Improves Growth Performance, and Reduces Intestinal Permeability in Piglets. Appl. Environ. Microbiol., 84.
Xu, S., Shi, J., Dong, Y., Li, Z., Wu, X., Lin, Y., Che, L., Li, J., Feng, B., and Fang, Z. (2020). Fecal Bacteria and Metabolite Responses to Dietary Lysozyme in a Sow Model from Late Gestation until Lactation. Sci. Rep., 10.
Cheng, C., Wu, X., Zhang, X., Zhang, X., and Peng, J. (2020). Obesity of Sows at Late Pregnancy Aggravates Metabolic Disorder of Perinatal Sows and Affects Performance and Intestinal Health of Piglets. Animals, 10.
Cheng, C., Wei, H., Yu, H., Xu, C., Jiang, S., and Peng, J. (2018). Metabolic Syndrome during Perinatal Period in Sows and the Link with Gut Microbiota and Metabolites. Front. Microbiol., 9.
Legrand, 2010, A Critical Review of the Roles of Host Lactoferrin in Immunity, BioMetals, 23, 365, 10.1007/s10534-010-9297-1
Buderus, S., Boone, J.H., and Lentze, M.J. (2015). Fecal Lactoferrin: Reliable Biomarker for Intestinal Inflammation in Pediatric IBD. Gastroenterol. Res. Pract., 2015.
Sipponen, 2013, Diagnostics and Prognostics of Inflammatory Bowel Disease with Fecal Neutrophil-Derived Biomarkers Calprotectin and Lactoferrin, Dig. Dis., 31, 336, 10.1159/000354689
Gisbert, 2009, Questions and Answers on the Role of Fecal Lactoferrin as a Biological Marker in Inflammatory Bowel Disease, Inflamm. Bowel Dis., 15, 1746, 10.1002/ibd.20920
Hansberry, D.R., Shah, K., Agarwal, P., and Agarwal, N. (2017). Fecal Myeloperoxidase as a Biomarker for Inflammatory Bowel Disease. Cureus, 9.
Huang, 2016, Methods for Measuring Myeloperoxidase Activity toward Assessing Inhibitor Efficacy in Living Systems, J. Leukoc. Biol., 99, 541, 10.1189/jlb.3RU0615-256R
Klebanoff, 2013, Myeloperoxidase: A Front-Line Defender against Phagocytosed Microorganisms, J. Leukoc. Biol., 93, 185, 10.1189/jlb.0712349
Masoodi, 2009, Fecal Lactoferrin, Myeloperoxidase and Serum C-Reactive Are Effective Biomarkers in the Assessment of Disease Activity and Severity in Patients with Idiopathic Ulcerative Colitis, J. Gastroenterol. Hepatol., 24, 1768, 10.1111/j.1440-1746.2009.06048.x
Hanifeh, M., Sankari, S., Rajamäki, M.M., Syrjä, P., Kilpinen, S., Suchodolski, J.S., Heilmann, R.M., Guadiano, P., Lidbury, J., and Steiner, J.M. (2018). S100A12 Concentrations and Myeloperoxidase Activities Are Increased in the Intestinal Mucosa of Dogs with Chronic Enteropathies. BMC Vet. Res., 14.
Masoodi, 2012, Evaluation of Fecal Myeloperoxidase as a Biomarker of Disease Activity and Severity in Ulcerative Colitis, Dig. Dis. Sci., 57, 1336, 10.1007/s10620-012-2027-5
Yi, 2018, Establishment of a Porcine Model of Indomethacin-Induced Intestinal Injury, Front. Biosci. Landmark, 23, 2166, 10.2741/4697
Khan, A., Alsahli, M., and Rahmani, A. (2018). Myeloperoxidase as an Active Disease Biomarker: Recent Biochemical and Pathological Perspectives. Med. Sci., 6.
Olza, 2012, Myeloperoxidase Is an Early Biomarker of Inflammation and Cardiovascular Risk in Prepubertal Obese Children, Diabetes Care, 35, 2373, 10.2337/dc12-0614
Schindhelm, 2009, Myeloperoxidase: A Useful Biomarker for Cardiovascular Disease Risk Stratification?, Clin. Chem., 55, 1462, 10.1373/clinchem.2009.126029
Berdowska, 2001, Neopterin Measurement in Clinical Diagnosis, J. Clin. Pharm. Ther., 26, 319, 10.1046/j.1365-2710.2001.00358.x
Fuchs, D., Weiss, G., and Wachter, H. (1993). Neopterin, Biochemistry and Clinical Use as a Marker for Cellular Immune Reactions. Int. Arch. Allergy Immunol., 101.
Hoffmann, 2003, Potential Role of Immune System Activation-Associated Production of Neopterin Derivatives in Humans, Inflamm. Res., 52, 313, 10.1007/s00011-003-1181-9
Husain, 2013, Neopterin Concentration as an Index of Disease Activity in Crohn’s Disease and Ulcerative Colitis, J. Clin. Gastroenterol., 47, 246, 10.1097/MCG.0b013e3182582cdb
Nancey, 2013, Neopterin Is a Novel Reliable Fecal Marker as Accurate as Calprotectin for Predicting Endoscopic Disease Activity in Patients with Inflammatory Bowel Diseases, Inflamm. Bowel Dis., 19, 1043, 10.1097/MIB.0b013e3182807577
Svoboda, 2011, Neopterin and Biopterin as Biomarkers of Immune System Activation Associated with Castration in Piglets, J. Anim. Sci., 89, 1758, 10.2527/jas.2010-3157
Svoboda, 2015, Concentrations of Neopterin, Biopterin, and Cortisol Associated with Surgical Castration of Piglets with Lidocaine, Czech J. Anim. Sci., 60, 473, 10.17221/8555-CJAS
Murray, M., Coughlan, M.T., Gibbon, A., Kumar, V., Marques, F.Z., Selby-Pham, S., Snelson, M., Tsyganov, K., Williamson, G., and Woodruff, T.M. (2022). Reduced Growth, Altered Gut Microbiome and Metabolite Profile, and Increased Chronic Kidney Disease Risk in Young Pigs Consuming a Diet Containing Highly Resistant Protein. Front. Nutr., 9.
Altindag, 2003, Neopterin as a New Biomarker for the Evaluation of Occupational Exposure to Silica, Int. Arch. Occup. Environ. Health, 76, 318, 10.1007/s00420-003-0434-9
Firoz, 2015, Neopterin: An Immune Biomarker of Coronary Artery Disease and Its Association with Other CAD Markers, IUBMB Life, 67, 453, 10.1002/iub.1390
Baydar, 2009, Neopterin as a Prognostic Biomarker in Intensive Care Unit Patients, J. Crit. Care, 24, 318, 10.1016/j.jcrc.2008.06.013
Melichar, B., Spisarová, M., Bartoušková, M., Krcmová, L.K., Javorská, L., and Študentová, H. (2017). Neopterin as a Biomarker of Immune Response in Cancer Patients. Ann. Transl. Med., 5.
Cirillo, 2011, Neopterin: From Forgotten Biomarker to Leading Actor in Cardiovascular Pathophysiology, Curr. Vasc. Pharmacol., 9, 188, 10.2174/157016111794519372
Glatz, 1996, Cellular fatty acid-binding proteins: Their function and physiological significance, Prog. Lipid Res., 35, 243, 10.1016/S0163-7827(96)00006-9
Pott, 2012, Innate Immune Signalling at the Intestinal Epithelium in Homeostasis and Disease, EMBO Rep., 13, 684, 10.1038/embor.2012.96
Lau, E., Marques, C., Pestana, D., Santoalha, M., Carvalho, D., Freitas, P., and Calhau, C. (2016). The Role of I-FABP as a Biomarker of Intestinal Barrier Dysfunction Driven by Gut Microbiota Changes in Obesity. Nutr. Metab., 13.
Pelsers, 2003, Intestinal-Type and Liver-Type Fatty Acid-Binding Protein in the Intestine. Tissue Distribution and Clinical Utility, Clin. Biochem., 36, 529, 10.1016/S0009-9120(03)00096-1
Ockner, 1974, Fatty Acid Binding Protein in Small Intestine. Identification, Isolation, and Evidence for Its Role in Cellular Fatty Acid Transport, J. Clin. Investig., 54, 326, 10.1172/JCI107768
Kano, 2015, Prediction of Reversibility of Intestinal Mucosal Damage after Ischemia-Reperfusion Injury by Plasma Intestinal Fatty Acid-Binding Protein Levels in Pigs, Perfusion, 30, 617, 10.1177/0267659114566063
Yu, 2019, I-FABP, Pig-MAP and TNF-α as Biomarkers for Monitoring Gut-Wall Integrity in Front of Salmonella Typhimurium and ETEC K88 Infection in a Weaned Piglet Model, Res. Vet. Sci., 124, 426, 10.1016/j.rvsc.2019.05.004
Niewold, 2004, Plasma Intestinal Fatty Acid Binding Protein (I-FABP) Concentrations Increase Following Intestinal Ischemia in Pigs, Res. Vet. Sci., 77, 89, 10.1016/j.rvsc.2004.02.006
Zhang, Q., Wu, T., Li, S., Meng, Y., Tan, Z., Wu, M., Yi, D., Wang, L., Zhao, D., and Hou, Y. (2021). Protective Effect of Zinc Oxide and Its Association with Neutrophil Degranulation in Piglets Infected with Porcine Epidemic Diarrhea Virus. Oxid. Med. Cell Longev., 2021.
Liu, 2021, Necroptosis Is Active and Contributes to Intestinal Injury in a Piglet Model with Lipopolysaccharide Challenge, Cell Death Dis., 12, 62, 10.1038/s41419-020-03365-1
Salt, 2014, The Value of the Serum I-FABP Level for Diagnosing Acute Mesenteric Ischemia, Surg. Today, 44, 2072, 10.1007/s00595-013-0810-3
Cahyaningsih, U., Satyaningtijas, A.S., Tarigan, R., and Nugraha, A.B. (2018). Chicken I-FABP as Biomarker of Chicken Intestinal Lesion Caused by Coccidiosis. IOP Conf. Ser. Earth Environ. Sci., 196.
Li, L., Wang, M., Chen, J., Xu, Z., Wang, S., Xia, X., Liu, D., Wang, S., Xie, C., and Wu, J. (2021). Preventive Effects of Bacillus Licheniformis on Heat Stroke in Rats by Sustaining Intestinal Barrier Function and Modulating Gut Microbiota. Front. Microbiol., 12.
McGrath, 2009, Structure and Inhibition of Human Diamine Oxidase, Biochemistry, 48, 9810, 10.1021/bi9014192
Luk, 1983, Plasma Postheparin Diamine Oxidase Sensitive Provocative Test for Quantitating Length of Acute Intestinal Mucosal Injury in the Rat, J. Clin. Investig., 71, 1308, 10.1172/JCI110881
Wolvekamp, 1994, Diamine Oxidase: An Overview of Historical, Biochemical and Functional Aspects, Dig. Dis., 12, 2, 10.1159/000171432
Dieryck, I., de Backere, J., and Paeshuyse, J. (2022). Effect of Hatching System and Prophylactic Antibiotic Use on Serum Levels of Intestinal Health Biomarker Diamine Oxidase in Broilers at an Early Age. Animal, 16.
Tsunooka, 2006, Localization and Changes of Diamine Oxidase during Cardiopulmonary Bypass in Rabbits, J. Surg. Res., 131, 58, 10.1016/j.jss.2005.10.004
Song, 2017, Dietary Supplementation of Enzymatically Treated Artemisia Annua Could Alleviate the Intestinal Inflammatory Response in Heat-Stressed Broilers, J. Therm. Biol., 69, 184, 10.1016/j.jtherbio.2017.07.015
Zhang, L., Zhang, L., Zhan, X., Zeng, X., Zhou, L., Cao, G., Chen, A., and Yang, C. (2016). Effects of Dietary Supplementation of Probiotic, Clostridium Butyricum, on Growth Performance, Immune Response, Intestinal Barrier Function, and Digestive Enzyme Activity in Broiler Chickens Challenged with Escherichia coli K88. J. Anim. Sci. Biotechnol., 7.
Liu, 2018, Effect of Yeast Cell Wall on the Growth Performance and Gut Health of Broilers Challenged with Aflatoxin B 1 and Necrotic Enteritis, Poult. Sci., 97, 477, 10.3382/ps/pex342
Liu, 2012, Fish Oil Enhances Intestinal Integrity and Inhibits TLR4 and NOD2 Signaling Pathways in Weaned Pigs after LPS Challenge, J. Nutr., 142, 2017, 10.3945/jn.112.164947
Hou, 2012, Protective Effects of N-Acetylcysteine on Intestinal Functions of Piglets Challenged with Lipopolysaccharide, Amino Acids, 43, 1233, 10.1007/s00726-011-1191-9
Wang, 2017, N-Acetylcysteine Supplementation Alleviates Intestinal Injury in Piglets Infected by Porcine Epidemic Diarrhea Virus, Amino Acids, 49, 1931, 10.1007/s00726-017-2397-2
Zhang, J., Zhao, D., Yi, D., Wu, M., Chen, H., Wu, T., Zhou, J., Li, P., Hou, Y., and Wu, G. (2019). Microarray Analysis Reveals the Inhibition of Intestinal Expression of Nutrient Transporters in Piglets Infected with Porcine Epidemic Diarrhea Virus. Sci. Rep., 9.
Çakmaz, R., Büyükaşik, O., Kahramansoy, N., Erkol, H., Çöl, C., Boran, Ç., and Buǧdayci, G. (2013). A Combination of Plasma DAO and Citrulline Levels as a Potential Marker for Acute Mesenteric Ischemia. Libyan J. Med., 8.
Wang, S., Yang, J., Zhang, B., Wu, K., Yang, A., Li, C., Zhang, J., Zhang, C., Rajput, S.A., and Zhang, N. (2018). Deoxynivalenol Impairs Porcine Intestinal Host Defense Peptide Expression in Weaned Piglets and IPEC-J2 Cells. Toxins, 10.
Crenn, 2008, Citrulline as a Biomarker of Intestinal Failure Due to Enterocyte Mass Reduction, Clin. Nutr., 27, 328, 10.1016/j.clnu.2008.02.005
Wu, 1994, Synthesis of Citrulline from Glutamine in Pig Enterocytes, Biochem. J., 299, 115, 10.1042/bj2990115
Szczylik, 2014, Plasma Citrulline Level as a Biomarker for Cancer Therapy-Induced Small Bowel Mucosal Damage, Acta Biochim. Pol., 61, 615
Ye, F., Ning, J., Fardous, Z., Katsube, T., Li, Q., and Wang, B. (2020). Citrulline, A Potential Biomarker of Radiation-Induced Small Intestine Damage. Dose-Response, 18.
Herbers, 2013, Citrulline and Albumin as Biomarkers for Gastrointestinal Mucositis in Recipients of Hematopoietic SCT, Bone Marrow Transpl., 48, 977, 10.1038/bmt.2012.278
Lutgens, 2007, Biomarkers for Radiation-Induced Small Bowel Epithelial Damage: An Emerging Role for Plasma Citrulline, World J. Gastroenterol., 13, 3033, 10.3748/wjg.v13.i22.3033
Jäckel, S., Pipp, F.C., Emde, B., Weigt, S., Vigna, E., Hanschke, B., Kasper, L., Siddharta, A., Hellmann, J., and Czasch, S. (2021). L-Citrulline: A Preclinical Safety Biomarker for the Small Intestine in Rats and Dogs in Repeat Dose Toxicity Studies. J. Pharmacol. Toxicol. Methods, 111.
Shin, 2019, Simultaneous Analysis of Acetylcarnitine, Proline, Hydroxyproline, Citrulline, and Arginine as Potential Plasma Biomarkers to Evaluate NSAIDs-Induced Gastric Injury by Liquid Chromatography–Tandem Mass Spectrometry, J. Pharm. Biomed. Anal., 165, 101, 10.1016/j.jpba.2018.11.051
Sacoor, 2020, What Are the Potential Biomarkers That Should Be Considered in Diagnosing and Managing Canine Chronic Inflammatory Enteropathies?, Open Vet. J., 10, 412, 10.4314/ovj.v10i4.9
Allen, 2018, Determining Optimal Therapy of Dogs with Chronic Enteropathy by Measurement of Serum Citrulline, J. Vet. Intern. Med., 32, 993, 10.1111/jvim.15124
Fasano, 2012, Zonulin, Regulation of Tight Junctions, and Autoimmune Diseases, Ann. N. Y. Acad. Sci., 1258, 25, 10.1111/j.1749-6632.2012.06538.x
Vanuytsel, T., Vermeire, S., and Cleynen, I. (2013). The Role of Haptoglobin and Its Related Protein, Zonulin, in Inflammatory Bowel Disease. Tissue Barriers, 1.
Panigrahi, 2002, Host-Dependent Zonulin Secretion Causes the Impairment of the Small Intestine Barrier Function after Bacterial Exposure, Gastroenterology, 123, 1607, 10.1053/gast.2002.36578
Clemente, 2003, Early Effects of Gliadin on Enterocyte Intracellular Signalling Involved in Intestinal Barrier Function, Gut, 52, 218, 10.1136/gut.52.2.218
Fasano, 2012, Intestinal Permeability and Its Regulation by Zonulin: Diagnostic and Therapeutic Implications, Clin. Gastroenterol. Hepatol., 10, 1096, 10.1016/j.cgh.2012.08.012
2017, Fecal Zonulin Is Elevated in Crohn’s Disease and in Cigarette Smokers, Pract. Lab. Med., 9, 39, 10.1016/j.plabm.2017.09.001
Szymanska, E., Wierzbicka, A., Dadalski, M., and Kierkus, J. (2021). Fecal Zonulin as a Noninvasive Biomarker of Intestinal Permeability in Pediatric Patients with Inflammatory Bowel Diseases—Correlation with Disease Activity and Fecal Calprotectin. J. Clin. Med., 10.
Rossi, G., Gavazza, A., Vincenzetti, S., Mangiaterra, S., Galosi, L., Marchegiani, A., Pengo, G., Sagratini, G., Ricciutelli, M., and Cerquetella, M. (2021). Clinicopathological and Fecal Proteome Evaluations in 16 Dogs Presenting Chronic Diarrhea Associated with Lymphangiectasia. Vet. Sci., 8.
Meineri, G., Martello, E., Atuahene, D., Miretti, S., Stefanon, B., Sandri, M., Biasato, I., Corvaglia, M.R., Ferrocino, I., and Cocolin, L.S. (2022). Effects of Saccharomyces Boulardii Supplementation on Nutritional Status, Fecal Parameters, Microbiota, and Mycobiota in Breeding Adult Dogs. Vet. Sci., 9.
Ohlsson, 2017, Calprotectin in Serum and Zonulin in Serum and Feces Are Elevated after Introduction of a Diet with Lower Carbohydrate Content and Higher Fiber, Fat and Protein Contents, Biomed. Rep., 6, 411, 10.3892/br.2017.865
Louis, 2017, Gut Permeability Is Related to Body Weight, Fatty Liver Disease, and Insulin Resistance in Obese Individuals Undergoing Weight Reduction, Am. J. Clin. Nutr., 105, 127, 10.3945/ajcn.116.131110
Xiong, 2019, Icariin Enhances Intestinal Barrier Function by Inhibiting NF-ΚB Signaling Pathways and Modulating Gut Microbiota in a Piglet Model, RSC Adv., 9, 37947, 10.1039/C9RA07176H
Xu, Y., Li, Y., Scott, K., Lindh, C.H., Jakobsson, K., Fletcher, T., Ohlsson, B., and Andersson, E.M. (2020). Inflammatory Bowel Disease and Biomarkers of Gut Inflammation and Permeability in a Community with High Exposure to Perfluoroalkyl Substances through Drinking Water. Environ. Res., 181.
Raetz, 2002, Lipopolysaccharide Endotoxins, Annu. Rev. Biochem., 71, 635, 10.1146/annurev.biochem.71.110601.135414
Sulc, R., Szekely, G., Shinde, S., Wierzbicka, C., Vilela, F., Bauer, D., and Sellergren, B. (2017). Phospholipid Imprinted Polymers as Selective Endotoxin Scavengers. Sci. Rep., 7.
Cheng, 2019, Early Intervention with Faecal Microbiota Transplantation: An Effective Means to Improve Growth Performance and the Intestinal Development of Suckling Piglets, Animal, 13, 533, 10.1017/S1751731118001611
Xiong, 2020, Icariin and Its Phosphorylated Derivatives Alleviate Intestinal Epithelial Barrier Disruption Caused by Enterotoxigenic Escherichia coli through Modulate P38 MAPK in Vivo and in Vitro, FASEB J., 34, 1783, 10.1096/fj.201902265R
Hall, 2001, Mechanisms of Circulatory and Intestinal Barrier Dysfunction during Whole Body Hyperthermia, Am. J. Physiol. Heart Circ. Physiol., 280, 509, 10.1152/ajpheart.2001.280.2.H509
Liu, B., Zhu, X., Cui, Y., Wang, W., Liu, H., Li, Z., Guo, Z., Ma, S., Li, D., and Wang, C. (2022). Consumption of Dietary Fiber from Different Sources during Pregnancy Alters Sow Gut Microbiota and Improves Performance and Reduces Inflammation in Sows and Piglets. mSystems, 6.
Mokkala, 2017, Increased Intestinal Permeability, Measured by Serum Zonulin, Is Associated with Metabolic Risk Markers in Overweight Pregnant Women, Metabolism, 69, 43, 10.1016/j.metabol.2016.12.015
Ewaschuk, 2005, D-Lactate in Human and Ruminant Metabolism, J. Nutr., 135, 1619, 10.1093/jn/135.7.1619
Montagnana, M., Danese, E., and Lippi, G. (2018). Biochemical Markers of Acute Intestinal Ischemia: Possibilities and Limitations. Ann. Transl. Med., 6.
Shi, 2015, The Role of Serum Intestinal Fatty Acid Binding Protein Levels and D-Lactate Levels in the Diagnosis of Acute Intestinal Ischemia, Clin. Res. Hepatol. Gastroenterol., 39, 373, 10.1016/j.clinre.2014.12.005
Nielsen, 2015, D-Lactate Is a Valid Biomarker of Intestinal Ischemia Induced by Abdominal Compartment Syndrome, J. Surg. Res., 194, 400, 10.1016/j.jss.2014.10.057
Nielsen, 2011, D-Lactate as a Marker of Venous-Induced Intestinal Ischemia: An Experimental Study in Pigs, Int. J. Surg., 9, 428, 10.1016/j.ijsu.2011.04.004
Zhao, 2019, Short-Chain Fructo-Oligosaccharides Enhances Intestinal Barrier Function by Attenuating Mucosa Inflammation and Altering Colonic Microbiota Composition of Weaning Piglets, Ital. J. Anim. Sci., 18, 976, 10.1080/1828051X.2019.1612286
Wang, Y., Wang, W., Wang, R., Hao, X., Duan, Y., Meng, Z., An, X., and Qi, J. (2020). Dietary Fermented Soybean Meal Inclusion Improves Growth Performance and Ileal Barrier Function of the Weaned Piglets Challenged by Enterotoxigenic Escherichia coli K88. Anim. Feed Sci. Technol., 268.
Wu, M., Xiao, H., Ren, W., Yin, J., Tan, B., Liu, G., Li, L., Nyachoti, C.M., Xiong, X., and Wu, G. (2014). Therapeutic Effects of Glutamic Acid in Piglets Challenged with Deoxynivalenol. PLoS ONE, 9.
Zhang, H., Chen, Y., Chen, Y., Ji, S., Jia, P., Li, Y., and Wang, T. (2020). Comparison of the Protective Effects of Resveratrol and Pterostilbene against Intestinal Damage and Redox Imbalance in Weanling Piglets. J. Anim. Sci. Biotechnol., 11.
Prakash, 2019, Concentrations of Interleukin-6, -8, -10 and Tumour Necrosis Factor-α in the Faeces of Dogs with Acute Diarrhoea, N. Z. Vet. J., 67, 138, 10.1080/00480169.2019.1582368
El, 2020, Study of the Diagnostic Value of Interleukin-6 and Interleukin-8 in Children with Acute Gastroenteritis, Germs, 10, 27, 10.18683/germs.2020.1182
Stauber, 2013, Intestinal Inflammatory Biomarkers and Outcome in Pediatric Clostridium Difficile Infections, J. Pediatr., 163, 1697, 10.1016/j.jpeds.2013.07.029
Kishton, 2016, A Guide to Immunometabolism for Immunologists, Nat. Rev. Immunol., 16, 553, 10.1038/nri.2016.70
Donohoe, 2012, Metaboloepigenetics: Interrelationships between Energy Metabolism and Epigenetic Control of Gene Expression, J. Cell Physiol., 227, 3169, 10.1002/jcp.24054
Shen, W., Gao, C., Cueto, R., Liu, L., Fu, H., Shao, Y., Yang, W.Y., Fang, P., Choi, E.T., and Wu, Q. (2020). Homocysteine-Methionine Cycle Is a Metabolic Sensor System Controlling Methylation-Regulated Pathological Signaling. Redox Biol., 28.
Jung, 2019, Metabolism as a Guiding Force for Immunity, Nat. Cell Biol., 21, 85, 10.1038/s41556-018-0217-x
Oller, 2020, Glycolysis–a Key Player in the Inflammatory Response, FEBS J., 287, 3350, 10.1111/febs.15327
2020, Cytokine-like Roles for Metabolites in Immunity, Mol. Cell, 78, 814, 10.1016/j.molcel.2020.04.002
Chauhan, 2018, Metabolic Regulation of Infection and Inflammation, Cytokine, 112, 1, 10.1016/j.cyto.2018.11.016
McGettrick, 2020, The Role of HIF in Immunity and Inflammation, Cell Metab., 32, 524, 10.1016/j.cmet.2020.08.002
2020, Targeting Immunometabolism as an Anti-Inflammatory Strategy, Cell Res., 30, 300, 10.1038/s41422-020-0291-z
Ryan, 2020, Krebs Cycle Reborn in Macrophage Immunometabolism, Annu. Rev. Immunol., 38, 289, 10.1146/annurev-immunol-081619-104850
Harber, K.J., de Goede, K.E., Verberk, S.G.S., Meinster, E., de Vries, H.E., van Weeghel, M., de Winther, M.P.J., and van den Bossche, J. (2020). Succinate Is an Inflammation-Induced Immunoregulatory Metabolite in Macrophages. Metabolites, 10.
Fortuny, L., and Sebastián, C. (2021). Sirtuins as Metabolic Regulators of Immune Cells Phenotype and Function. Genes, 12.
Peace, C.G., and O’Neill, L.A.J. (2022). The Role of Itaconate in Host Defense and Inflammation. J. Clin. Investig., 132.
Masson, N., and Ratcliffe, P.J. (2014). Hypoxia Signaling Pathways in Cancer Metabolism: The Importance of Co-Selecting Interconnected Physiological Pathways. Cancer Metab., 2.
Corcoran, 2016, HIF1α and Metabolic Reprogramming in Inflammation, J. Clin. Investig., 126, 3699, 10.1172/JCI84431
Katayama, 2003, Basic-Alimentary Tract A Novel PPAR Gene Therapy to Control Inflammation Associated with Inflammatory Bowel Disease in a Murine Model, Gastroenterology, 124, 1315, 10.1016/S0016-5085(03)00262-2
Croasdell, A., Duffney, P.F., Kim, N., Lacy, S.H., Sime, P.J., and Phipps, R.P. (2015). PPAR γ and the Innate Immune System Mediate the Resolution of Inflammation. PPAR Res., 2015.
Mauro, 2011, NF-ΚB Controls Energy Homeostasis and Metabolic Adaptation by Upregulating Mitochondrial Respiration, Nat. Cell Biol., 13, 1272, 10.1038/ncb2324
Johnson, 2012, Nuclear Factor-ΚB, P53, and Mitochondria: Regulation of Cellular Metabolism and the Warburg Effect, Trends Biochem. Sci., 37, 317, 10.1016/j.tibs.2012.04.002
Mills, 2014, Succinate: A Metabolic Signal in Inflammation, Trends Cell Biol., 24, 313, 10.1016/j.tcb.2013.11.008
Salvador, 2019, Succinate Receptor Mediates Intestinal Inflammation and Fibrosis, Mucosal. Immunol., 12, 178, 10.1038/s41385-018-0087-3
Zotta, 2020, Is Citrate A Critical Signal in Immunity and Inflammation?, J. Cell. Signal. Rev. Artic., 1, 87
Navarro, 2022, Nicotinamide Adenine Dinucleotide Metabolism in the Immune Response, Autoimmunity and Inflammageing, Br. J. Pharmacol., 179, 1839, 10.1111/bph.15477
Rongvaux, 2002, Pre-B-Cell Colony-Enhancing Factor, Whose Expression Is up-Regulated in Activated Lymphocytes, Is a Nicotinamide Phosphoribosyltransferase, a Cytosolic Enzyme Involved in NAD Biosynthesis, Eur. J. Immunol., 32, 3225, 10.1002/1521-4141(200211)32:11<3225::AID-IMMU3225>3.0.CO;2-L
Gerner, 2018, NAD Metabolism Fuels Human and Mouse Intestinal Inflammation, Gut, 67, 1813, 10.1136/gutjnl-2017-314241
Vachharajani, V.T., Liu, T., Wang, X., Hoth, J.J., Yoza, B.K., and McCall, C.E. (2016). Sirtuins Link Inflammation and Metabolism. J. Immunol. Res., 2016.
Kogut, 2016, AMPK and MTOR: Sensors and Regulators of Immunometabolic Changes during Salmonella Infection in the Chicken, Poult. Sci., 95, 345, 10.3382/ps/pev349
Richards, 2007, 5′-AMP-Activated Protein Kinase in Avian Biology, Avian Poult. Biol. Rev., 18, 123, 10.3184/147020607X314294
2013, Metabolism of Inflammation Limited by AMPK and Pseudo-Starvation, Nature, 493, 346, 10.1038/nature11862
Yang, 2014, The AMPK-PPARGC1A Pathway Is Required for Antimicrobial Host Defense through Activation of Autophagy, Autophagy, 10, 785, 10.4161/auto.28072
Blagih, 2015, The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo, Immunity, 42, 41, 10.1016/j.immuni.2014.12.030
Laplante, 2012, MTOR Signaling in Growth Control and Disease, Cell, 149, 274, 10.1016/j.cell.2012.03.017
Cobbold, 2013, The MTOR Pathway and Integrating Immune Regulation, Immunology, 140, 391, 10.1111/imm.12162
Powell, 2012, Regulation of Immune Responses by MTOR, Annu. Rev. Immunol., 30, 39, 10.1146/annurev-immunol-020711-075024