Morphobase, an Encyclopedic Cell Morphology Database, and Its Use for Drug Target Identification

Abassi, 2009, Kinetic cell-based morphological screening: prediction of mechanism of compound action and off-target effects, Chem. Biol., 16, 712, 10.1016/j.chembiol.2009.05.011 Brinkley, 1974, Rotenone inhibition of spindle microtubule assembly in mammalian cells, Exp. Cell Res., 85, 41, 10.1016/0014-4827(74)90210-9 Chen, 1977, Properties of mammalian cells transformed by temperature-sensitive mutants of avian sarcoma virus, Cell, 11, 513, 10.1016/0092-8674(77)90069-1 Diccianni, 2004, 3-amino thioacridone inhibits DNA synthesis and induce DNA damage in T-cell acute lymphoblastic leukemia (T-ALL) in a p16-dependent manner, J. Exp. Ther. Oncol., 4, 223 Feng, 2009, Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds, Nat. Rev. Drug Discov., 8, 567, 10.1038/nrd2876 Fenteany, 1995, Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin, Science, 268, 726, 10.1126/science.7732382 Frémont, 2000, Biological effects of resveratrol, Life Sci., 66, 663, 10.1016/S0024-3205(99)00410-5 Frost, 1995, A whole-cell Candida albicans assay for the detection of inhibitors towards fungal cell wall synthesis and assembly, J. Antibiot. (Tokyo), 48, 306, 10.7164/antibiotics.48.306 Gunji, 1983, Screening of antifungal antibiotics according to activities inducing morphological abnormalities, Agric. Biol. Chem., 47, 2061, 10.1271/bbb1961.47.2061 Houle, 2010, Phenomics: the next challenge, Nat. Rev. Genet., 11, 855, 10.1038/nrg2897 Huberman, 1979, Induction of terminal differentiation in human promyelocytic leukemia cells by tumor-promoting agents, Proc. Natl. Acad. Sci. USA, 76, 1293, 10.1073/pnas.76.3.1293 Jain, 2012, Eribulin mesylate in the treatment of metastatic breast cancer, Biologics, 6, 21 Kakeya, 1995, Epolactaene, a novel neuritogenic compound in human neuroblastoma cells, produced by a marine fungus, J. Antibiot. (Tokyo), 48, 733, 10.7164/antibiotics.48.733 Kawatani, 2011, Identification of a small-molecule inhibitor of DNA topoisomerase II by proteomic profiling, Chem. Biol., 18, 743, 10.1016/j.chembiol.2011.03.012 Kong, 2010, Discovery of phosphatidylinositol 3-kinase inhibitory compounds from the Screening Committee of Anticancer Drugs (SCADS) library, Biol. Pharm. Bull., 33, 1600, 10.1248/bpb.33.1600 Kubo, 1999, The p16 status of tumor cell lines identifies small molecule inhibitors specific for cyclin-dependent kinase 4, Clin. Cancer Res., 5, 4279 Leone, 2010, Resveratrol induces DNA double-strand breaks through human topoisomerase II interaction, Cancer Lett., 295, 167, 10.1016/j.canlet.2010.02.022 Luo, 2008, Global impact of oncogenic Src on a phosphotyrosine proteome, J. Proteome Res., 7, 3447, 10.1021/pr800187n MacDonald, 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells, Nat. Chem. Biol., 2, 329, 10.1038/nchembio790 Motoyama, 2012, Terpendole E, a kinesin Eg5 inhibitor, is a key biosynthetic intermediate of indole-diterpenes in the producing fungus Chaunopycnis alba, Chem. Biol., 19, 1611, 10.1016/j.chembiol.2012.10.010 Muroi, 2010, Application of proteomic profiling based on 2D-DIGE for classification of compounds according to the mechanism of action, Chem. Biol., 17, 460, 10.1016/j.chembiol.2010.03.016 Ohnuki, 2010, High-content, image-based screening for drug targets in yeast, PLoS One, 5, e10177, 10.1371/journal.pone.0010177 Omura, 1991, Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells, J. Antibiot. (Tokyo), 44, 113, 10.7164/antibiotics.44.113 Osada, 2010, Introduction of new tools for chemical biology research on microbial metabolites, Biosci. Biotechnol. Biochem., 74, 1135, 10.1271/bbb.100061 Osada, 1988, Rapid screening method for inhibitors of protein kinase C, J. Antibiot. (Tokyo), 41, 925, 10.7164/antibiotics.41.925 Osada, 1991, Reveromycin A, a new antibiotic which inhibits the mitogenic activity of epidermal growth factor, J. Antibiot. (Tokyo), 44, 259, 10.7164/antibiotics.44.259 Osada, 1997, Screening of cell cycle inhibitors from microbial metabolites by a bioassay using a mouse cdc2 mutant cell line, tsFT210, Bioorg. Med. Chem., 5, 193, 10.1016/S0968-0896(96)00207-6 Pepperkok, 2006, High-throughput fluorescence microscopy for systems biology, Nat. Rev. Mol. Cell Biol., 7, 690, 10.1038/nrm1979 Perlman, 2004, Multidimensional drug profiling by automated microscopy, Science, 306, 1194, 10.1126/science.1100709 Roti, 2012, Genetic and proteomic approaches to identify cancer drug targets, Br. J. Cancer, 106, 254, 10.1038/bjc.2011.543 Screpanti, 2010, A screen for kinetochore-microtubule interaction inhibitors identifies novel antitubulin compounds, PLoS One, 5, e11603, 10.1371/journal.pone.0011603 Sumiya, 2011, Cell-morphology profiling of a natural product library identifies bisebromoamide and miuraenamide A as actin filament stabilizers, ACS Chem. Biol., 6, 425, 10.1021/cb1003459 Takahashi, 1992, Reveromycins, new inhibitors of eukaryotic cell growth. II. Biological activities, J. Antibiot. (Tokyo), 45, 1414, 10.7164/antibiotics.45.1414 Thomas, 1997, Cellular functions regulated by Src family kinases, Annu. Rev. Cell Dev. Biol., 13, 513, 10.1146/annurev.cellbio.13.1.513 Uehara, 1986, Phenotypic change from transformed to normal induced by benzoquinonoid ansamycins accompanies inactivation of p60src in rat kidney cells infected with Rous sarcoma virus, Mol. Cell. Biol., 6, 2198, 10.1128/MCB.6.6.2198 Whitesell, 1994, Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation, Proc. Natl. Acad. Sci. USA, 91, 8324, 10.1073/pnas.91.18.8324 Yoshida, 2007, Antiproliferating activity of the mitotic inhibitor pironetin against vindesine- and paclitaxel-resistant human small cell lung cancer H69 cells, Anticancer Res., 27, 729