Morphine affects cytostatic activity of macrophages by the modulation of nitric oxide release

Bryant, 1988, Morphine pellet-induced immunomodulation in mice: temporal relationship, J. Pharmac. exp. Ther., 245, 913 Bryant, 1991, Role of adrenal cortical activation in the immunosuppressive effects of chronic morphine treatment, Endocrinology, 128, 3253, 10.1210/endo-128-6-3253 Calignano, 1993, Endogenous nitric oxide modulates morphine-induced changes in locomotion and food intake in mice, Eur. J. Pharmac., 231, 415, 10.1016/0014-2999(93)90118-2 Cappendijik, 1993, Inhibitory effect of nitric oxide (NO) synthase inhibitors on naloxone-precipitated withdrawal syndrome in morphine dependent mice, Neurosci. Lett., 162, 97, 10.1016/0304-3940(93)90569-7 Dahlstrom, 1978, Relation between morphine pharmacokinetics and analgesia, J. Pharmacokin. Biopharmac., 6, 41, 10.1007/BF01066062 Danahoe, 1987, Mechanistic implications of the finding that opiates and other drugs of abuse moderate T-cell surface receptors and antigenic markers, Ann. N.Y. Acad. Sci., 496, 711, 10.1111/j.1749-6632.1987.tb35834.x Ferreira, 1991, The molecular mechanism of action of peripheral morphine analgesia: stimulation of the cGMP system via nitric oxide release, Eur. J. Pharmac., 201, 121, 10.1016/0014-2999(91)90333-L Green, 1982, Analysis of nitrate, nitrite and [15N]nitrate in biological fluids, Analyt. Biochem., 126, 131, 10.1016/0003-2697(82)90118-X Henry, 1993, EPR characterization of molecular targets for NO in mammalian cells and organelles, FASEB J., 7, 1124, 10.1096/fasebj.7.12.8397130 Hibbs, 1988, Nitric oxide: a cytotoxic activated macrophage effector molecule, Biochem. biophys. Res. Commun., 157, 87, 10.1016/S0006-291X(88)80015-9 Ignarro, 1993, Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically tormed nitric oxide from L-arginine, 90, 8103 Kolesnikov, 1992, NG-Nitro-l-arginine prevents morphine tolerance, Eur. J. Pharmac., 221, 399, 10.1016/0014-2999(92)90732-J Millan, 1988, Antagonist-induced opioid receptor up-regulation. I. Characterization of supersensitivity to selective mu and kappa agonists, J. Pharmac. exp. Ther., 247, 721 Moncada, 1992, The l-arginine: nitric oxide pathway, Acta Physiol. scand., 145, 201, 10.1111/j.1748-1716.1992.tb09359.x Pacifici, 1993, Macrophage functions in drugs of abuse treated mice, Int. J. Immunopharmac., 15, 711, 10.1016/0192-0561(93)90143-M Pacifici, 1994, Effect of morphine and methadone acute treatment on immunological activity in mice: pharmacokinetic and pharmacodynamic correlates, J. Pharmac. exp. Ther., 269, 1112 Pacifici, 1995, Liquid chromatography-electrospray mass spectrometry determination of morphine and its 3- and 6-glucuronides: application to pharmacokinetic studies, J. Chromatogr., 664, 329, 10.1016/0378-4347(94)00496-R Roy, 1991, Chronic morphine treatment selectively suppresses macrophage colony formation in bone marrow, Eur. J. Pharmac., 195, 359, 10.1016/0014-2999(91)90476-7 Sei, 1991, Morphine-induced thymic hypoplasia is glucocorticoid-dependent, J. Immun., 146, 194, 10.4049/jimmunol.146.1.194 Stuehr, 1989, Nitric oxide, 169, 1543 Tempel, 1982, Supersensitivity of brain opiate receptor subtypes after chronic naltrexone treatment, Life Sci., 31, 1401, 10.1016/0024-3205(82)90391-5 Tubaro, 1985, Morphine and methadone impact on human phagocytic physiology, Int. J. Immunopharmac., 7, 865, 10.1016/0192-0561(85)90049-9 Tubaro, 1983, Effect of morphine on resistance to infection, J. infect. Dis., 148, 656, 10.1093/infdis/148.4.656