Monte Carlo Simulation of Degradation of Porous Poly(lactide) Scaffolds, 1

Macromolecular Theory and Simulations - Tập 15 Số 9 - Trang 643-653 - 2006
Yousef Mohammadi1, Esmaiel Jabbari2
1Department of Chemical Engineering, Biomaterials and Tissue Engineering Laboratories, University of South Carolina, Columbia 29208, USA
2Department of Chemical Engineering, Biomaterials and Tissue Engineering Laboratories, University of South Carolina, Columbia 29208, USA Fax: (+1) 803 777 0973

Tóm tắt

AbstractSummary: Monte Carlo method was used to simulate the degradation of porous PLA scaffolds. The simulated volume was assumed to be divided homogeneously between the pore and solid PLA with the ratio equal to the bulk porosity of the scaffold. The volume was divided into surface and bulk elements where the surface elements were in direct contact with the aqueous degradation medium, while the bulk elements were surrounded by the pore and solid PLA. The effect of degradation time on PLA ester groups and carboxylic acid end‐groups for surface and bulk elements, pH, PLA degradation rate and mass loss, and PLA molecular weight distribution was simulated. For surface elements, pH remained constant at 7.4 over the entire time of degradation, while for bulk elements its value decreased significantly to as low as 5.8. The highest drop in pH within the scaffold was observed for the highest porosity of 90%. There was a lag time of at least 7 weeks in the mass loss for surface as well as bulk elements for porosities ranging from 70 to 90%. The mass loss for bulk elements was considerably faster than the surface elements. This difference in the rate of mass loss between the surface and bulk elements could affect the 3D morphology and dimensional stability of the scaffold in vivo as degradation proceeds. The simulation predicts that, due to differences in the rate of bulk and surface degradation, hollow structures could form inside the scaffold after 19, 17, and 15 weeks for initial porosities of 70, 80, and 90%, respectively.A schematic diagram illustrating the degradation of an element on the outer surface of the scaffold (surface element) versus an element within the volume of the scaffold (bulk element).imageA schematic diagram illustrating the degradation of an element on the outer surface of the scaffold (surface element) versus an element within the volume of the scaffold (bulk element).

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Tài liệu tham khảo

10.1016/S0142-9612(02)00466-0

Charbit Y., 1999, Biomed. Instrum. Technol., 33, 71

10.1615/CritRevTherDrugCarrierSyst.v19.i1.20

10.1016/j.ijom.2005.02.013

10.1002/jbm.a.30487

10.1016/j.biomaterials.2005.05.069

10.1016/j.biomaterials.2004.06.030

10.1111/j.1749-6632.1965.tb47455.x

10.1002/mabi.200500062

10.1089/ten.2005.11.438

10.1163/1568562042459733

10.1016/j.biomaterials.2004.10.037

Jabbari E., 2004, Tissue Engineering in Musculoskeletal Clinical Practice

10.1002/mabi.200400026

10.1016/S0142-9612(03)00340-5

10.22203/eCM.v005a01

10.1016/0032-3861(81)90045-8

10.1002/jbm.10050

Yoo J. Y., 2005, Biomed. Mater. Eng., 15, 279

10.1163/15685620360511155

10.1163/156856206774879126

10.1007/s10856-006-6816-2

10.1016/0141-3910(95)00067-V

10.1021/ma00209a035

10.1016/S0168-3659(96)01533-7

10.1016/S0032-3861(96)00921-4

Fluendly M., 1970, Markov Chains and Monte Carlo Calculations in Polymer Science, 45

10.1145/272991.272995

10.1021/j100540a008

10.1016/0141-3910(96)00009-2

10.1002/(SICI)1097-4628(19990222)71:8<1223::AID-APP2>3.0.CO;2-I

Yoo Y. J., 2005, Biomed. Mater. Eng., 15, 279

10.1016/j.eurpolymj.2005.01.026

10.1016/j.polymer.2006.01.021

10.1016/S0939-6411(01)00130-8

10.1021/ma011163q

10.1021/ma049077o

10.1016/0142-9612(90)90124-9

10.1002/app.10813

10.1016/0142-9612(81)90060-0

10.1016/S0142-9612(00)00048-X

10.1002/(SICI)1097-4628(19990222)71:8<1223::AID-APP2>3.0.CO;2-I

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Macromolecular Theory and Simulations

Tập 15 Số 9

643-653

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