Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice
Tóm tắt
Từ khóa
Tài liệu tham khảo
Ng, 2014, Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013, Lancet, 384, 766, 10.1016/S0140-6736(14)60460-8
Dee, 2014, The direct and indirect costs of both overweight and obesity: a systematic review, BMC Research Notes, 7, 242, 10.1186/1756-0500-7-242
Tuomilehto, 2001, Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance, The New England Journal of Medicine, 344, 1343, 10.1056/NEJM200105033441801
Wadden, 2005, Randomized trial of lifestyle modification and pharmacotherapy for obesity, The New England Journal of Medicine, 353, 2111, 10.1056/NEJMoa050156
Krentz, 2016, Evolution of pharmacological obesity treatments: focus on adverse side-effect profiles, Diabetes, Obesity and Metabolism, 18, 558, 10.1111/dom.12657
Schauer, 2014, Bariatric surgery versus intensive medical therapy for diabetes–3-year outcomes, The New England Journal of Medicine, 370, 2002, 10.1056/NEJMoa1401329
Hoerger, 2010, Cost-effectiveness of bariatric surgery for severely obese adults with diabetes, Diabetes Care, 33, 1933, 10.2337/dc10-0554
Fuchs, 2015, Benefits of bariatric surgery do not reach obese men, Journal of Laparoendoscopic & Advanced Surgical Techniques Part A, 25, 196, 10.1089/lap.2014.0639
Nguyen, 2010, The epidemiology of obesity, Gastroenterology Clinics of North America, 39, 1, 10.1016/j.gtc.2009.12.014
Pettersson, 2012, Female mice are protected against high-fat diet induced metabolic syndrome and increase the regulatory T cell population in adipose tissue, PLoS One, 7, e46057, 10.1371/journal.pone.0046057
Hong, 2009, Differential susceptibility to obesity between male, female and ovariectomized female mice, Nutrition Journal, 8, 11, 10.1186/1475-2891-8-11
Wizemann, 2001
Shi, 2009, Sex differences in the regulation of body weight, Physiology& Behavior, 97, 199, 10.1016/j.physbeh.2009.02.017
Franconi, 2007, Gender differences in drug responses, Pharmacological Research, 55, 81, 10.1016/j.phrs.2006.11.001
Martin, 1998, Age and sex distribution of suspected adverse drug reactions to newly marketed drugs in general practice in England: analysis of 48 cohort studies, British Journal of Clinical Pharmacology, 46, 505, 10.1046/j.1365-2125.1998.00817.x
Clayton, 2014, Policy: NIH to balance sex in cell and animal studies, Nature, 509, 282, 10.1038/509282a
Tschöp, 2012, Outstanding Scientific Achievement Award Lecture 2011: defeating diabesity: the case for personalized combinatorial therapies, Diabetes, 61, 1309, 10.2337/db12-0272
Tschöp, 2016, Unimolecular polypharmacy for treatment of diabetes and obesity, Cell Metabolism, 24, 51, 10.1016/j.cmet.2016.06.021
Finan, 2015, A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents, Nature Medicine, 21, 27, 10.1038/nm.3761
Yang, 2014, Variations in body weight, food intake and body composition after long-term high-fat diet feeding in C57BL/6J mice, Obesity (Silver Spring), 22, 2147, 10.1002/oby.20811
National Institutes of Health, 2011
Clemmensen, 2014, GLP-1/glucagon coagonism restores leptin responsiveness in obese mice chronically maintained on an obesogenic diet, Diabetes, 63, 1422, 10.2337/db13-1609
Matthews, 1985, Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man, Diabetologia, 28, 412, 10.1007/BF00280883
Hofmann, 2008, Defective lipid delivery modulates glucose tolerance and metabolic response to diet in apolipoprotein E-deficient mice, Diabetes, 57, 5, 10.2337/db07-0403
Kleiner, 2005, Design and validation of a histological scoring system for nonalcoholic fatty liver disease, Hepatology, 41, 1313, 10.1002/hep.20701
Morselli, 2014, Hypothalamic PGC-1alpha protects against high-fat diet exposure by regulating ERalpha, Cell Reports, 9, 633, 10.1016/j.celrep.2014.09.025
Lundgren, 1990, Fasting serum insulin concentration and early insulin response as risk determinants for developing diabetes, Diabetic Medicine, 7, 407, 10.1111/j.1464-5491.1990.tb01415.x
Spruss, 2012, Female mice are more susceptible to nonalcoholic fatty liver disease: sex-specific regulation of the hepatic AMP-activated protein kinase-plasminogen activator inhibitor 1 cascade, but not the hepatic endotoxin response, Molecular Medicine, 18, 1346, 10.2119/molmed.2012.00223
Ganz, 2014, High fat diet feeding results in gender specific steatohepatitis and inflammasome activation, World Journal of Gastroenterology, 20, 8525, 10.3748/wjg.v20.i26.8525
Ni, 2015, Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: a comparison with vitamin E, Scientific Reports, 5, 17192, 10.1038/srep17192
Giannini, 2005, Liver enzyme alteration: a guide for clinicians, CMAJ, 172, 367, 10.1503/cmaj.1040752
Yin, 2011, Assessment of different bariatric surgeries in the treatment of obesity and insulin resistance in mice, Annals of Surgery, 254, 73, 10.1097/SLA.0b013e3182197035