Monokine production by microglial cell clones

European Journal of Immunology - Tập 19 Số 8 - Trang 1443-1448 - 1989
Marco Righi1, Lucia Mori1, Gennaro De Libero1,2, Marina Sironi3, Andrea Biondi3, Alberto Mantovani3, Suzanne Denis Donini4, Paola Ricciardi‐Castagnoli5
1Department of Biology,Milano
2L. Mori was supported by the Italian Association for Cancer Research and G. De Libero by a CNR fellowship.
3CNR Center of Cytopharmacology, Institute "Mario Negri", Milano
4University of Milano, Milano
5CNR Center of Cytopharmacology, Via Vanvitelli, 32, I-20129 Milano, Italy

Tóm tắt

AbstractCytokines have been suggested to act as intermediates between the immune and the central nervous system, but little is known about the type of cells synthesizing them in the brain. We have immortalized with oncogenic retroviruses primary brain cell cultures from mouse embryos and have generated clones of microglial cells that have been characterized. Three of the clones studied produce interleukin 1 (IL 1), IL 6 and tumor necrosis factor‐α as assessed by biological assays and by Northern blot analysis. Our data raise the question on the role of these cytokines in the brain and suggest that early resident microglial cells might play an important role in developmental processes and in the adult brain.

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Tài liệu tham khảo

10.1126/science.2821620

10.1126/science.2443979

10.1084/jem.164.2.594

10.1083/jcb.102.3.803

10.1083/jcb.102.3.812

Rio Hortega S., 1932, Cytology and Cellular Pathology of the nervous system, 481

10.1002/cne.901800109

10.1002/cne.901930304

10.1016/0306-4522(85)90215-5

10.1016/0012-1606(81)90476-0

Righi M., 1989, Oncogene, 4, 223

10.1016/0006-8993(76)90257-2

10.1002/eji.1830111013

10.1002/eji.1830090410

10.1038/303390a0

10.1073/pnas.79.8.2709

10.1093/ajcp/55.3.283

10.1098/rspb.1974.0060

10.4049/jimmunol.137.4.1226

10.1073/pnas.83.24.9679

10.1084/jem.165.3.641

10.1016/0022-1759(83)90303-4

Colotta F., 1984, J. Immunol., 132, 936, 10.4049/jimmunol.132.2.936

10.1016/0022-1759(86)90322-4

10.1038/312458a0

10.1093/nar/14.19.7713

10.1002/eji.1830180202

10.1083/jcb.101.6.2411

Morrison D. C., 1978, Am. J. Pathol., 93, 527

Ogmundsdottir Y., 1986, Immunology, 37, 689

10.1007/BF00218004

Weiel J. E., 1986, J. Immunol., 136, 2812, 10.4049/jimmunol.136.8.3012

10.1073/pnas.83.16.5817

10.1126/science.2821621

10.1126/science.3258444

10.4049/jimmunol.139.2.459

10.1016/S0006-291X(88)80805-2

10.1002/eji.1830180427

10.1016/S0006-291X(88)81305-6

10.1021/bi00420a001

10.1016/0165-5728(87)90375-4

10.1126/science.3306918

10.1073/pnas.84.20.7242

10.1016/0165-5728(87)90286-4

10.1038/329630a0

Zhang Y., 1988, Proc. Natl. Acad. Sci. USA, 85, 6892

10.1002/eji.1830170214

Thông tin
Thông tin xuất bản

European Journal of Immunology

Tập 19 Số 8

1443-1448

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