Protein hóa học hấp dẫn bạch cầu đơn nhân-1 và hàng rào máu-não

Cellular and Molecular Life Sciences - Tập 71 - Trang 683-697 - 2013
Yao Yao1,2, Stella E. Tsirka1
1Program in Molecular and Cellular Pharmacology, Department of Pharmacological Sciences, BST8-192, Stony Brook University, Stony Brook, USA
2Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, USA

Tóm tắt

Hàng rào máu-não (BBB) là một cấu trúc động có vai trò duy trì trạng thái ổn định của não và do đó là chức năng thần kinh đúng đắn. Việc suy giảm BBB đã được phát hiện trong nhiều tình trạng bệnh lý, bao gồm cả viêm thần kinh. Protein hóa học hấp dẫn bạch cầu đơn nhân-1 (MCP1), một cytokine được điều chỉnh tạm thời và đáng kể trong quá trình viêm, có khả năng phá hủy tính toàn vẹn của BBB và điều chỉnh sự tiến triển của nhiều bệnh lí khác nhau, bao gồm tổn thương do kích thích quá mức và xuất huyết. Trong bài đánh giá này, chúng tôi trước tiên giới thiệu hóa sinh và sinh học của MCP1, và sau đó tóm tắt tác động của MCP1 đối với tính toàn vẹn của BBB cũng như các thành phần riêng lẻ của BBB.

Từ khóa

#Hàng rào máu-não #Protein hóa học hấp dẫn bạch cầu đơn nhân-1 #Viêm thần kinh #Tổn thương kích thích quá mức #Xuất huyết

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