Monocyte antibody-dependent cellular cytotoxicity in cancer patients
Tóm tắt
Antibody-dependent cellular cytotoxicity (ADCC) mediated by peripheral blood monocytes was determined in 120 patients who had gastrointestinal tract (GIT), lung and breast cancer, melanoma, or Hodgkin's and non-Hodgkin's lymphoma. Results were expressed in terms of maximum cytotoxicity and cytotoxicity at E : T=1 : 10 and were compared with the results obtained in 63 normal subjects. There was a significant decrease in maximal cytotoxicity for both the GIT cancer and the melanoma patient groups, but not for any of the other groups. These differences were not confirmed when results were expressed at low effector: target cell ratios, e.g., cytotoxicity at E : T=1 : 10. The relationship between monocyte ADCC and disease extent was examined in those groups with sufficient numbers. Monocyte ADCC was higher in patients with GIT cancer of limited extent than in patients with extensive GIT cancer and in the control group.
Tài liệu tham khảo
Baldwin RW, Robins RA (1976) Host immune responses to tumours. In: Symington T, Carter RL (eds) Scientific foundations of oncology. Heinemann, Chicago, p 514
Boetcher DA, Leonard EJ (1974) Abnormal monocyte chemotactic response in cancer patients. J Natl Cancer Inst 52:1091
Currie GA, Hedley DW (1977) Monocytes and macrophages in malignant melanoma. I. Peripheral blood macrophage precursors. Br J Cancer 36:1
De Young NJ, Gill PG (1982) Hemolytic capacity of human monocytes in normal subjects. Int Arch Allergy Appl Immunol 68:305
Eccles SA, Alexander P (1974) Macrophage content in tumours in relation to metastatic spread and host immune reaction. Nature 250:667
Estevez MA, Sen L, Bachmann AE, Pavlovsky A (1980) Defective function of peripheral blood monocytes in patients with Hodgkin's and non-Hodgkin's lymphomas. Cancer 46:299
Gerrard TL, Terz JJ, Kaplan AM (1980) Cytotoxicity to tumour cells of monocytes from normal individuals and cancer patients. Int J Cancer 26:585
Gill PG, Waller CA, MacLennan ICM (1977) Relationships between different functional properties of human monocytes. Immunology 33:873
Gill PG, De Young NJ, Kiroff GK, Leppard PI, McLennan G (1984) Monocyte antibody-dependent cellular cytotoxicity in splenectomized subjects. J Immunol 132:1244
Hersh EM, Murphy SG, Gutterman JV et al. (1982) Antibody-dependent cell-mediated cytotoxicity in human cancer: characterization of patient leukocyte activity and treatment effects. Cancer 49:251
Holm G, Hammarstrom S (1983) Haemolytic activity of human blood monocytes. Lysis of human erythrocytes treated with anti-A serum. Clin Exp Immunol 13:29
Kay AB, McVie JG (1977) Monocyte chemotaxis in bronchial carcinoma and cigarette smokers. Br J Cancer 36:461
Kjeldsberg CR, Pay GD (1978) A qualitative and quantitative study of monocytes in patients with malignant solid tumours. Cancer 41:2236
Kleinerman ES, Zwelling LA, Howser D et al. (1980) Defective monocyte killing in patients with malignancies and restoration of function during chemotherapy. Lancet 2:1102
Kohn S, Pickering LK, Sullivan MP, Walters DL (1980) Impaired monocyte — macrophage cytotoxicity in patients with Hodgkin's disease. Clin Immunol Immunopathol 15:577
Krishnan EC, Menon CD, Krishnan L, Jewell WR (1982) Quantitative studies of monocyte maturation in patients with malignant melanoma. J Surg Res 33:386
LoBuglio AF (1970) Effect of neoplasia on human macrophage membrane activity. J Lab Clin Med 76:888
McVie JG, Logan ECM, Kay AB (1977) Monocyte function in cancer patients. Eur J Cancer 13:351
Nathan CF, Murray HW, Cohn ZA (1980) The macrophage as an effector cell. N Engl J Med 303:622
Neilsen H, Bennedsen J, Larsen SO, Dombernowsky P, Viskum K (1982) A quantitative and qualitative study of blood monocytes in patients with bronchogenic carcinoma. Cancer Immunol Immunother 13:93
Nyholm RE, Currie GA (1978) Monocytes and macrophages in malignant melanoma. II. Lysis of antibody-coated human erythrocytes as an assay of monocyte function. Br J Cancer 37:337
Pehamberger H, Holubar K, Knapp W (1980) Effect of BCG on monocyte-mediated antibody-dependent cellular cytotoxicity in stage I melanoma. Cancer 46:1135
Pehamberger H, Ludwig H, Potzi P, Knapp W (1980) Increased monocyte-mediated antibody-dependent cellular cytotoxicity (ADCC) in Hodgkin's disease. Br J Cancer 41:778
Poplack DG, Bonnard GD, Holiman BJ, Blaese RM (1976) Monocyte-mediated antibody-dependent cellular cytotoxicity: a clinical test of monocyte function. Blood 48:809
Rhodes J (1977) Altered expression of human monocyte Fc receptors in malignant disease. Nature 265:253
Ruco LP, Procopio A, Uccini S, Baroni CD (1980) Increased monocyte phagocytosis in cancer patients. Eur J Cancer 16:1315
Samak R, Israel L, Edelstein R (1980) Influence of tumour burden, tumour removal, immune stimulation and plasmaphoresis on monocyte mobilization in cancer patients. In: Escobar MR, Friedan H (eds) Macrophages and lymphocytes. Plenum, New York, p 411
Snyderman R, Seigler HF, Meadows L (1977) Abnormalities of monocyte chemotaxis in patients with melanoma: Effects of Immunotherapy and tumour removal. J Natl Cancer Inst 58:37
Snyderman R, Meadows L, Holder W, Wells S (1978) Abnormal monocyte chemostasis in patients with breast cancer. Evidence for a tumour mediated effect. J Natl Cancer Inst 60:737
Uracz W, Pituch-Noworolska A, Zembala M, Popiela T, Czupryna A (1982) “Activated” monocytes in gastric cancer patients. I. Increased Fc receptor expression, antibody-dependent cellular cytotoxicity and NBT reduction. J Cancer Res Clin Oncol 104:181
Van Loveren H, Den Otter W (1974) Macrophages in Solid Tumors. I. Immunologically Specific Effector Cells. J. Natl Cancer Inst 53:1057
Waldmann TA, Strober W, Blaese RM (1972) Immunodeficiency disease and malignancy: Various immunologic deficiencies of man and the role of immune processes in the control of malignant disease. Ann Intern Med 77:605