Monoamine Oxidases: From Tissue Homogenates to Transgenic Mice

Shih JC, Chen K, Ridd MJ (1999) Monoamine oxidases: from genes to behavior. Annu Rev Neurosci 22:197–217 Shih JC, Thompson RF (1999) Monoamine oxidase in neuropsychiatry and behavior. Am J Hum Genet 65:593–598 Youdim MBH, Collins GGS, Sandler M (1969) Multiple forms of rat brain monoamine oxidase. Nature 223:626–628 Shih JC, Eiduson S (1969) Multiple forms of monoamine oxidase in developing brain. Nature 224:1309–1311 Johnston JP (1968) Some observations upon a new inhibitor of monoamine oxidase in brain tissue. Biochem Pharmacol 17:1285–1297 Knoll J, Magyar K (1972) Some puzzling pharmacological effects of monoamine oxidase inhibitors. Adv Biochem Psychopharmacol 5:393–408 Bach AW, Lan NC, Johnson DL, Abell CW, Bembenek ME, Kwan SW, Seeburg PH, Shih JC (1988) cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties. Proc Natl Acad Sci U S A 85:4934–4938 Grimsby J, Chen K, Wang L-J, Lan NC, Shih JC (1991) Human monoamine oxidase A and B gene exhibit identical exon-intron organization. Digest Parkinson/Alzheimer 1:12–13 Lan NC, Heinzmann C, Gal A, Klisak I, Orth U, Lai E, Grimsby J, Sparkes RS, Mohandas T, Shih JC (1989) Human monoamine oxidase A and B genes map to Xp 11.23 and are deleted in a patient with Norrie disease. Genomics 4:552–559 Chen K, Wu HF, Grimsby J, Shih JC (1994) Cloning of a novel monoamine oxidase cDNA from trout liver. Mol Pharmacol 46:1226–1233 Geha RM, Rebrin I, Chen K, Shih JC (2001) Substrate and inhibitor specificities of human monoamine oxidase A and B are influenced by a single amino acid. J Biol Chem 276:9877–9882 Lan NC, Chen CH, Shih JC (1989) Expression of functional human monoamine oxidase A and B cDNAs in mammalian cells. J Neurochem 52:1652–1654 Wu HF, Chen K, Shih JC (1993) Site-directed mutagenesis of monoamine oxidase A and B role of cysteines. Mol Pharmacol 43:888–893 Geha RM, Chen K, Shih JC (2000) Phe208 and Ile199 in human monoamine oxidase A and B do not determine substrate and inhibitor specificities as in rat. J Neurochem 75:1304–1309 Rebrin I, Geha RM, Chen K, Shih JC (2001) Effects of carboxy-terminal truncations on the activity and solubility on human monoamine oxidase B. J Biol Chem 276:29499–29506 Geha RM, Chen K, Wouters J, Ooms F, Shih JC (2002) Analysis of conserved active site residues in monoamine oxidase A and B and their 3-dimensional molecular modeling. J Biol Chem 277:17209–17216 Binda C, Li M, Hubalek F, Restelli N, Edmondson DE, Mattevi A (2003) Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures. Proc Natl Acad Sci U S A 100:9750–9755 Ma J, Yoshimura M, Yamashita E, Nakagawa A, Ito A, Tsukihara T (2004) Structure of rat monoamine oxidase A and its specific recognitions forsubstrates and inhibitors. J Mol Biol 338:103–114 Zhu QS, Grimsby J, Chen K, Shih JC (1992) Promoter organization and activity of human monoamine oxidase (MAO) A and B genes. J Neurosci 12:4437–4446 Zhu QS, Chen K, Shih JC (1994) Bidirectional promoter of human monoamine oxidase A (MAO A) controlled by transcription factor Spl. J Neurosci 14:7393–7403 Zhu QS, Shih JC (1997) An extensive repeat structure down regulates human monoamine oxidase A promoter activity independent of an initiator like sequence. J Neurochem 69:1368–1373 Ou X-M, Chen K, Shih JC (2004) Dual functions of transcription factors, transforming growth factor-B-inducible early gene (TIEG)2 and Sp3, are mediated by CACCC element and Sp1 sites of human monoamine oxidase (MAO) B Gene. J Biol Chem 279:21021–21028 Ou X-M, Chen K, Shih JC (2006) Glucocorticoid and androgen activation of monoamine oxidase A are regulated by R1 and SP1. J Biol Chem 281:21512–21525 Zhang Z, Chen K, Shih JC, Cheng TC (2006) Estrogen receptors down-regulated the transactivation activity of estrogen-related receptors on the MAO B promoter. Mol Endocr 20:1547–1561 Wong WK, Ou X-M, Chen K, Shih JC (2002) Activation of human monoamine oxidase B gene expression by a protein kinase C, MAPK signal transduction pathway involves c-Jun and Egr-1. J Biol Chem 277:22222–22230 Sabol SZ, Hu S, Hamer D (1998) A functional polymorphism in the monoamine oxidase A gene promoter. Hum Genet 103:273–279 Chen K, Ou X-M, Chen G, Choi S, Shih JC (2005) R1, a novel repressor of the human monoamine oxidase A. J Biol Chem 280:11552–11559 Ou X-M, Chen K, Shih JC (2006) Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway. Proc Natl Acad Sci U S A 103:10923–10928 Brunner HG, Nelen MR, van Zandvoort P, Abeling NG, van Gennip AH, Wolters EC, Kuiper MA, Ropers HH, van Oost BA (1993) X-linked borderline mental retardation with prominent behavioral disturbance: phenotype, genetic localization, and evidence for disturbed monoamine metabolism. Am J Hum Genet 52:1032–1039 Brunner HG, Nelen M, Breakefield XO, Ropers HH, van Oost BA (1993) Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science 262:578–580 Cases O, Seif I, Grimsby J, Gaspar P, Chen K, Pournin S, Müller U, Aguet M, Babinet C, Shih JC, De Maeyer E (1995) Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAO A. Science 268:1763–1766 Kim JJ, Shih JC, Chen K, Chen L, Bao S, Maren S, Anagnostaras SG, Fanselow MS, De Maeyer E, Seif I, Thompson RF (1997) Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient mice. Proc Natl Acad Sci U S A 94:5929–5933 Grimsby J, Toth M, Chen K, Kumazawa T, Klaidman L, Adams JD, Karoum F, Gal J, Shih JC (1997) Increased stress response and beta-phenylethylamine in MAOB-deficient mice. Nat Genet 17:206–210 Holschneider DP, Scremin OU, Roos KP, Chialvo DR, Chen KP, Shih JC (2002) Increased baroreceptor response in mice deficient in monoamine oxidase A and B. Am J Physiol Heart Circ Physiol 282:H964–H972 Holschneider DP, Scremin OU, Chialvo DR, Chen K, Shih JC (2002) Heart rate dynamics in monoamine oxidase-A- and -B-deficient mice. Am J Physiol Heart Circ Physiol 282:H1751–H1759 Chen K, Holschneider DP, Wu W, Rebrin I, Shih JC (2004) A spontaneous point mutation produces MAO A/B knockout mice with greatly elevated levels of monoamines and anxiety-like behavior. J Biol Chem 279:39645–39652 Chen K, Cases O, Rebrin I, Wu W, Gallaher TK, Seif I, Shih JC (2007) Forebrain-specific expression of monoamine oxidase A reduces neurotransmitter levels, restores the brain structure, and rescues aggressive behavior in monoamine oxidase A-deficient mice. J Biol Chem 282:115–123