Molecular pathophysiology of hepatic glucose production

Accili, 2004, FoxOs at the crossroads of cellular metabolism, differentiation, and transformation, Cell, 117, 421, 10.1016/S0092-8674(04)00452-0 Ahlborg, 1976, Influence of lactate infusion on glucose and FFA metabolism in man, Scand. J. Clin. Lab. Invest, 36, 193, 10.3109/00365517609055248 Altarejos, 2011, CREB and the CRTC co-activators: sensors for hormonal and metabolic signals, Nat. Rev. Mol. Cell Biol, 12, 141, 10.1038/nrm3072 Ashcroft, 1989, Electrophysiology of the pancreatic beta-cell, Prog. Biophys. Mol. Biol, 54, 87, 10.1016/0079-6107(89)90013-8 Baron, 1988, Rates and tissue sites of non-insulin- and insulin-mediated glucose uptake in humans, Am. J. Physiol, 255, E769 Bays, 2004, Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach, J. Clin. Endocrinol. Metab, 89, 463, 10.1210/jc.2003-030723 Borg, 1997, Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats, J. Clin. Invest, 99, 361, 10.1172/JCI119165 Borg, 1994, Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia, J. Clin. Invest, 93, 1677, 10.1172/JCI117150 Borg, 1995, Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release, Diabetes, 44, 180, 10.2337/diab.44.2.180 Boyle, 2010, Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalence, Popul. Health Metr, 8, 29, 10.1186/1478-7954-8-29 Burant, 1992, Mammalian facilitative glucose transporters: evidence for similar substrate recognition sites in functionally monomeric proteins, Biochemistry, 31, 10414, 10.1021/bi00157a032 Campbell, 1988, Quantification of the relative impairment in actions of insulin on hepatic glucose production and peripheral glucose uptake in non-insulin-dependent diabetes mellitus, Metabolism, 37, 15, 10.1016/0026-0495(88)90023-6 Chen, 2012, The worldwide epidemiology of type 2 diabetes mellitus–present and future perspectives, Nat. Rev. Endocrinol, 8, 228, 10.1038/nrendo.2011.183 Cherrington, 1999, Banting Lecture 1997. Control of glucose uptake and release by the liver in vivo, Diabetes, 48, 1198, 10.2337/diabetes.48.5.1198 Clark, 1974, The fructose 1,6-diphosphatase-phosphofructokinase substrate cycle. A site of regulation of hepatic gluconeogenesis by glucagon, J. Biol. Chem, 249, 5695, 10.1016/S0021-9258(20)79874-1 Claus, 1980, Mechanism of action of glucagon on hepatocyte phosphofructokinase activity, Proc. Natl. Acad. Sci. U.S.A., 77, 6501, 10.1073/pnas.77.11.6501 Consoli, 1989, Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM, Diabetes, 38, 550, 10.2337/diab.38.5.550 Daitoku, 2004, Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity, Proc. Natl. Acad. Sci. U.S.A., 101, 10042, 10.1073/pnas.0400593101 Deacon, 2011, Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: a comparative review, Diabetes Obes. Metab, 13, 7, 10.1111/j.1463-1326.2010.01306.x DeFronzo, 2004, Pathogenesis of type 2 diabetes mellitus, Med. Clin. North Am, 88, 787, 10.1016/j.mcna.2004.04.013 DeFronzo, 1982, Hepatic and peripheral insulin resistance: a common feature of type 2 (non-insulin-dependent) and type 1 (insulin-dependent) diabetes mellitus, Diabetologia, 23, 313, 10.1007/BF00253736 DeFronzo, 1985, Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus, J. Clin. Invest, 76, 149, 10.1172/JCI111938 Diamond, 1988, Effect of alanine concentration independent of changes in insulin and glucagon on alanine and glucose homeostasis in the conscious dog, Metabolism, 37, 28, 10.1016/0026-0495(88)90025-X Dominy, 2012, The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis, Mol. Cell, 48, 900, 10.1016/j.molcel.2012.09.030 Drucker, 1998, Glucagon-like peptides, Diabetes, 47, 159, 10.2337/diab.47.2.159 El-Mir, 2000, Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I, J. Biol. Chem, 275, 223, 10.1074/jbc.275.1.223 Engstrom, 1978, The regulation of liver pyruvate kinase by phosphorylation–dephosphorylation, Curr. Top. Cell. Regul, 13, 28 Exton, 1967, Control of gluconeogenesis in liver. I. General features of gluconeogenesis in the perfused livers of rats, J. Biol. Chem, 242, 2622, 10.1016/S0021-9258(18)99617-1 Feliu, 1976, Hormonal control of pyruvate kinase activity and of gluconeogenesis in isolated hepatocytes, Proc. Natl. Acad. Sci. U.S.A., 73, 2762, 10.1073/pnas.73.8.2762 Firth, 1986, Postprandial hyperglycemia in patients with noninsulin-dependent diabetes mellitus. Role of hepatic and extrahepatic tissues, J. Clin. Invest, 77, 1525, 10.1172/JCI112467 Flory, 1974, Kinetic properties of rat liver pyruvate kinase at cellular concentrations of enzyme, substrates and modifiers, Biochem. J., 141, 127, 10.1042/bj1410127 Foretz, 2010, Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state, J. Clin. Invest, 120, 2355, 10.1172/JCI40671 Garrison, 1982, Glucagon and the Ca2+-linked hormones angiotensin II, norepinephrine, and vasopressin stimulate the phosphorylation of distinct substrates in intact hepatocytes, J. Biol. Chem, 257, 13135, 10.1016/S0021-9258(18)33633-0 Gastaldelli, 2001, Effect of physiological hyperinsulinemia on gluconeogenesis in nondiabetic subjects and in type 2 diabetic patients, Diabetes, 50, 1807, 10.2337/diabetes.50.8.1807 Gelling, 2006, Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes, Cell Metab, 3, 67, 10.1016/j.cmet.2005.11.013 Gerich, 2010, Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: therapeutic implications, Diabet. Med, 27, 136, 10.1111/j.1464-5491.2009.02894.x Gerich, 1990, Contribution of impaired muscle glucose clearance to reduced postabsorptive systemic glucose clearance in NIDDM, Diabetes, 39, 211, 10.2337/diab.39.2.211 Gribble, 1998, Tissue specificity of sulfonylureas: studies on cloned cardiac and beta-cell K(ATP) channels, Diabetes, 47, 1412, 10.2337/diabetes.47.9.1412 Groop, 1989, Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance, J. Clin. Invest, 84, 205, 10.1172/JCI114142 Haeusler, 2010, FoxOs function synergistically to promote glucose production, J. Biol. Chem, 285, 35245, 10.1074/jbc.C110.175851 Hasselgren, 1999, Glucocorticoids and muscle catabolism, Curr. Opin. Clin. Nutr. Metab. Care, 2, 201, 10.1097/00075197-199905000-00002 He, 2015, Metformin action: concentrations matter, Cell Metab, 21, 159, 10.1016/j.cmet.2015.01.003 Herzig, 2001, CREB regulates hepatic gluconeogenesis through the coactivator PGC-1, Nature, 413, 179, 10.1038/35093131 Holst, 2007, The physiology of glucagon-like peptide 1, Physiol. Rev, 87, 1409, 10.1152/physrev.00034.2006 Huang, 1980, Noninvasive determination of local cerebral metabolic rate of glucose in man, Am. J. Physiol, 238, E69 Inzucchi, 2012, Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD), Diabetologia, 55, 1577, 10.1007/s00125-012-2534-0 Iynedjian, 2009, Molecular physiology of mammalian glucokinase, Cell. Mol. Life Sci, 66, 27, 10.1007/s00018-008-8322-9 Jahoor, 1990, The relationship between gluconeogenic substrate supply and glucose production in humans, Am. J. Physiol, 258, E288 Jenssen, 1990, Failure of substrate-induced gluconeogenesis to increase overall glucose appearance in normal humans. Demonstration of hepatic autoregulation without a change in plasma glucose concentration, J. Clin. Invest, 86, 489, 10.1172/JCI114735 Johnson, 2013, The origins and drivers of insulin resistance, Cell, 152, 673, 10.1016/j.cell.2013.01.041 Knutti, 2000, A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen, Mol. Cell. Biol, 20, 2411, 10.1128/MCB.20.7.2411-2422.2000 Koo, 2005, The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism, Nature, 437, 1109, 10.1038/nature03967 Koranyi, 1990, Glucose transporter levels in spontaneously obese (db/db) insulin-resistant mice, J. Clin. Invest, 85, 962, 10.1172/JCI114526 Lam, 2005, Regulation of blood glucose by hypothalamic pyruvate metabolism, Science, 309, 943, 10.1126/science.1112085 Lambillotte, 1997, Direct glucocorticoid inhibition of insulin secretion. An in vitro study of dexamethasone effects in mouse islets, J. Clin. Invest, 99, 414, 10.1172/JCI119175 Lanthier, 2010, Kupffer cell activation is a causal factor for hepatic insulin resistance, Am. J. Physiol. Gastrointest. Liver Physiol, 298, G107, 10.1152/ajpgi.00391.2009 Lee, 2014, Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression, Nature, 510, 547, 10.1038/nature13267 Lerin, 2006, GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha, Cell Metab, 3, 429, 10.1016/j.cmet.2006.04.013 Lewis, 1997, Fatty acids mediate the acute extrahepatic effects of insulin on hepatic glucose production in humans, Diabetes, 46, 1111, 10.2337/diab.46.7.1111 Liang, 2004, Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db/db mice, Diabetes, 53, 410, 10.2337/diabetes.53.2.410 Lin, 2011, Hormonal regulation of hepatic glucose production in health and disease, Cell Metab, 14, 9, 10.1016/j.cmet.2011.06.003 Lu, 2012, Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1, Nat. Med, 18, 388, 10.1038/nm.2686 Lumeng, 2011, Inflammatory links between obesity and metabolic disease, J. Clin. Invest, 121, 2111, 10.1172/JCI57132 Lustig, 2011, Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase, Genes Dev, 25, 1232, 10.1101/gad.2054711 Madiraju, 2014, Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase, Nature, 510, 542, 10.1038/nature13270 Magnusson, 1992, Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study, J. Clin. Invest, 90, 1323, 10.1172/JCI115997 Martin, 2012, Metformin: a diabetes drug for cancer, or a cancer drug for diabetics?, J. Clin. Oncol, 30, 2698, 10.1200/JCO.2012.42.1677 Matschinsky, 1996, Banting Lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm, Diabetes, 45, 223, 10.2337/diab.45.2.223 Matsumoto, 2007, Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver, Cell Metab, 6, 208, 10.1016/j.cmet.2007.08.006 Matsuzaki, 2005, Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation, Proc. Natl. Acad. Sci. U.S.A., 102, 11278, 10.1073/pnas.0502738102 Meek, 1984, Effects of phosphorylation on the kinetic properties of rat liver fructose-1,6-bisphosphatase, Biochem. J., 222, 125, 10.1042/bj2220125 Michael, 2000, Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction, Mol. Cell, 6, 87, 10.1016/S1097-2765(05)00015-8 Miller, 2013, Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP, Nature, 494, 256, 10.1038/nature11808 Mitrakou, 1991, Hierarchy of glycemic thresholds for counterregulatory hormone secretion, symptoms, and cerebral dysfunction, Am. J. Physiol, 260, E67 Moore, 2012, Regulation of hepatic glucose uptake and storage in vivo, Adv. Nutr, 3, 286, 10.3945/an.112.002089 Mutel, 2011, Control of blood glucose in the absence of hepatic glucose production during prolonged fasting in mice: induction of renal and intestinal gluconeogenesis by glucagon, Diabetes, 60, 3121, 10.2337/db11-0571 Neyrinck, 2009, Critical role of Kupffer cells in the management of diet-induced diabetes and obesity, Biochem. Biophys. Res. Commun, 385, 351, 10.1016/j.bbrc.2009.05.070 Obici, 2002, Hypothalamic insulin signaling is required for inhibition of glucose production, Nat. Med, 8, 1376, 10.1038/nm1202-798 Obstfeld, 2010, C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis, Diabetes, 59, 916, 10.2337/db09-1403 Opherk, 2004, Inactivation of the glucocorticoid receptor in hepatocytes leads to fasting hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitus, Mol. Endocrinol, 18, 1346, 10.1210/me.2003-0283 Owen, 2000, Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain, Biochem. J., 348, 607, 10.1042/bj3480607 Peckett, 2011, The effects of glucocorticoids on adipose tissue lipid metabolism, Metabolism, 60, 1500, 10.1016/j.metabol.2011.06.012 Pilkis, 1992, Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis, Annu. Rev. Physiol, 54, 885, 10.1146/annurev.ph.54.030192.004321 Pilkis, 1983, The action of insulin on hepatic fructose 2,6-bisphosphate metabolism, J. Biol. Chem, 258, 1495, 10.1016/S0021-9258(18)33012-6 Pilkis, 1995, 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase: a metabolic signaling enzyme, Annu. Rev. Biochem, 64, 799, 10.1146/annurev.bi.64.070195.004055 Proks, 2002, Sulfonylurea Stimulation of Insulin Secretion, Diabetes, 51, S368, 10.2337/diabetes.51.2007.S368 Puigserver, 1998, A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis, Cell, 92, 829, 10.1016/S0092-8674(00)81410-5 Puigserver, 2003, Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction, Nature, 423, 550, 10.1038/nature01667 Quesada, 2008, Physiology of the pancreatic α-cell and glucagon secretion: role in glucose homeostasis and diabetes, J. Endocrinol, 199, 5, 10.1677/JOE-08-0290 Quinn, 1990, Cyclic AMP-dependent protein kinase regulates transcription of the phosphoenolpyruvate carboxykinase gene but not binding of nuclear factors to the cyclic AMP regulatory element, Mol. Cell. Biol, 10, 3357, 10.1128/MCB.10.7.3357 Raju, 2005, Maintenance of the postabsorptive plasma glucose concentration: insulin or insulin plus glucagon?, Am. J. Physiol. Endocrinol. Metab, 289, E181, 10.1152/ajpendo.00460.2004 Rebrin, 1995, Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin, Diabetes, 44, 1038, 10.2337/diab.44.9.1038 Rhee, 2003, Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis, Proc. Natl. Acad. Sci. U.S.A., 100, 4012, 10.1073/pnas.0730870100 Rizza, 2010, Pathogenesis of fasting and postprandial hyperglycemia in type 2 diabetes: implications for therapy, Diabetes, 59, 2697, 10.2337/db10-1032 Rizza, 1980, Adrenergic mechanisms of catecholamine action on glucose homeostasis in man, Metabolism, 29, 1155, 10.1016/0026-0495(80)90025-6 Rodgers, 2005, Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1, Nature, 434, 113, 10.1038/nature03354 Rodgers, 2010, Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis, Cell Metab, 11, 23, 10.1016/j.cmet.2009.11.006 Routh, 2004, Neuronal glucosensing what do we know after 50 years?, Diabetes, 53, 2521, 10.2337/diabetes.53.10.2521 Saltiel, 2001, Insulin signalling and the regulation of glucose and lipid metabolism, Nature, 414, 799, 10.1038/414799a Samuel, 2012, Mechanisms for insulin resistance: common threads and missing links, Cell, 148, 852, 10.1016/j.cell.2012.02.017 Screaton, 2004, The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector, Cell, 119, 61, 10.1016/j.cell.2004.09.015 Shaw, 2005, The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin, Science, 310, 1642, 10.1126/science.1120781 She, 2000, Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism, Mol. Cell. Biol, 20, 6508, 10.1128/MCB.20.17.6508-6517.2000 She, 2003, Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation, Diabetes, 52, 1649, 10.2337/diabetes.52.7.1649 Sindelar, 1997, The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog, Diabetes, 46, 187, 10.2337/diab.46.2.187 Unger, 1970, Studies of pancreatic alpha cell function in normal and diabetic subjects, J. Clin. Invest, 49, 837, 10.1172/JCI106297 van Poelje, 2011, Fructose-1, 6-bisphosphatase inhibitors for reducing excessive endogenous glucose production in type 2 diabetes, Handb. Exp. Pharmacol, 203, 279, 10.1007/978-3-642-17214-4_12 Van Schaftingen, 1987, Fructose 2,6-bisphosphate, Adv. Enzymol. Relat. Areas Mol. Biol, 59, 315 Van Schaftingen, 1980, Control of the fructose-6-phosphate/fructose 1,6-bisphosphate cycle in isolated hepatocytes by glucose and glucagon. Role of a low-molecular-weight stimulator of phosphofructokinase, Biochem. J., 192, 887, 10.1042/bj1920887 Van Schaftingen, 1980, Fructose 2,6-bisphosphate, the probably structure of the glucose- and glucagon-sensitive stimulator of phosphofructokinase, Biochem. J., 192, 897, 10.1042/bj1920897 Watts, 2005, Reduction of hepatic and adipose tissue glucocorticoid receptor expression with antisense oligonucleotides improves hyperglycemia and hyperlipidemia in diabetic rodents without causing systemic glucocorticoid antagonism, Diabetes, 54, 1846, 10.2337/diabetes.54.6.1846 Wynshaw-Boris, 1986, Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. I. Multiple hormone regulatory elements and the effects of enhancers, J. Biol. Chem, 261, 9714, 10.1016/S0021-9258(18)67573-8 Yoon, 2001, Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1, Nature, 413, 131, 10.1038/35093050 Zhou, 2001, Role of AMP-activated protein kinase in mechanism of metformin action, J. Clin. Invest, 108, 1167, 10.1172/JCI13505