Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

Cell - Tập 80 Số 5 - Trang 695-705 - 1995
Kai W. Wucherpfennig1, Jack L. Strominger2
1Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138
2Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138 USA

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Allegretta, 1990, T cells responsive to myelin basic protein in patients with multiple sclerosis, Science, 247, 718, 10.1126/science.1689076

Baig, 1989, Cells producing antibody to measles and herpes simplex virus in cerebrospinal fluid and blood of patients with multiple sclerosis and controls, clin. Exp. Immunol., 78, 390

Brocke, 1993, Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superahtigen, Nature, 365, 642, 10.1038/365642a0

Brown, 1991, Recognition of the influenza hemagglutinin by class II MHC-restricted T lymphocytes and antibodies. I. Site definition and implications for antigen presentation and T lymphocyte recognition, J. Immunol., 147, 2677, 10.4049/jimmunol.147.8.2677

Brown, 1993, Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1, Nature, 364, 33, 10.1038/364033a0

Burns, 1983, Isolation of myelin basic protein-reactive T-cell lines from normal human blood, Cell. Immunol., 81, 435, 10.1016/0008-8749(83)90250-2

Burrows, 1994, An alloresponse in humans is dominated by cytotoxic T lymphocytes (CTL) clones cross-reactive with a single Epstein-Barr virus CTL epitope: implications for graft-versus-host disease, J. Exp. Med., 179, 1155, 10.1084/jem.179.4.1155

Busch, 1991, Effect of a natural polymorphism at residue 86 of the HLA-DR β chain on peptide binding, J. Immunol., 147, 1292, 10.4049/jimmunol.147.4.1292

Chambers, 1989, Antigenic and molecular characterization of subtype H13 hemagglutinin of influenza virus, Virology, 172, 180, 10.1016/0042-6822(89)90119-0

Cole, 1993, Triggering and exacerbation of autoimmune arthritis by the mycoplasma arthritidis superantigen MAM, Arthritis Rheum., 36, 994, 10.1002/art.1780360717

Conrad, 1994, Evidence for superantigen involvement in insulin-dependent diabetes mellitus aetiology, Nature, 371, 351, 10.1038/371351a0

Datta, 1980, Induction of Epstein-Barr virus-associated DNA polymerase by 12-O-tetradecanoylphorbol-13-acetate, J. Biol. Chem., 255, 5120, 10.1016/S0021-9258(19)70758-3

Epstein, 1977, Pathogenesis of infectious mononucleosis, Lancet, ii, 1270, 10.1016/S0140-6736(77)92673-3

Friedman, 1991, Characterization of human T cells reactive with the mycoplasma arthritidis-derived superantigen (MAM): generation of a monoclonal antibody against Vβ17, the T cell receptor gene product expressed by a large fraction of MAMreactive human T cells, J. Exp. Med., 174, 891, 10.1084/jem.174.4.891

Fujinami, 1985, Amino acid homology between the encephalitogenic site of myelin basic protein and virus: a mechanism for autoimmunity, Science, 230, 1043, 10.1126/science.2414848

Hickey, 1991, T-lymphocyte entry into the central nervous system, J. Neurosci. Res., 28, 254, 10.1002/jnr.490280213

Johnson, 1984, Measles encephalomyelitis: clinical and immunological studies, N Engl. J. Med., 310, 137, 10.1056/NEJM198401193100301

Kappler, 1987, T cell tolerance by clonal elimination in the thymus, Cell, 49, 273, 10.1016/0092-8674(87)90568-X

Kaufman, 1993, Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes, Nature, 366, 69, 10.1038/366069a0

Kisielow, 1988, Positive selection of antigen-specific T cells in thymus by restricting MHC molecules, Nature, 335, 730, 10.1038/335730a0

Kurtzke, 1985, Epidemiology of multiple sclerosis, 259

Kurtzke, 1979, Multiple sclerosis in the Faroe Islands: clinical and epidemiological features, Ann. Neurol., 5, 6, 10.1002/ana.410050104

Lehmann, 1992, Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen, Nature, 358, 155, 10.1038/358155a0

Madden, 1993, The antigenic identity of peptide-MHC complexes: a comparison of the conformation of five viral peptides presented by HLA-A2, Cell, 75, 693, 10.1016/0092-8674(93)90490-H

Martin, 1990, Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals, J. Immunol., 145, 540, 10.4049/jimmunol.145.2.540

Oldstone, 1990, Molecular mimicry and autoimmune disease, Cell, 50, 819, 10.1016/0092-8674(87)90507-1

Olerup, 1989, Primary chronic progressive and relapsing/remitting multiple sclerosis: two immunogenetically distinct disease entities, 86, 7113

Ota, 1990, T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis, Nature, 346, 183, 10.1038/346183a0

Pette, 1990, Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple sclerosis patients and healthy donors, 87, 7968

Ray, 1980, Coxsackie B virus antibody responses in juvenile-onset diabetes mellitus, Clin. Endocrinol., 12, 375, 10.1111/j.1365-2265.1980.tb02723.x

Reay, 1994, Use of global amino acid replacements to define the requirements for MHC binding and T cell recognition of moth cytochrome c (93–103), J. Immunol., 150, 3946, 10.4049/jimmunol.152.8.3946

Rose, 1986, Postinfectious autoimmunity: two distinct phases of coxsackie B3induced myocarditis, Ann. NY Acad. Sci., 475, 146, 10.1111/j.1749-6632.1986.tb20864.x

Schluesener, 1985, Autoaggressive T lymphocyte lines recognizing the encephalitogenic region of myelin basic protein: in vitro selection from unprimed T lymphocyte populations, J. Immunol., 135, 3128, 10.4049/jimmunol.135.5.3128

Schwarz, 1985, Structure and transcription of human papillomavirus sequences in cervical carcinoma cells, Nature, 314, 111, 10.1038/314111a0

Sebzda, 1994, Positive and negative thymocyte selection induced by different concentrations of a single peptide, Science, 263, 1615, 10.1126/science.8128249

Spielman, 1982, The genetics of susceptibility to multiple sclerosis, Epidemiol. Rev., 4, 45, 10.1093/oxfordjournals.epirev.a036251

Spruance, 1985, Pathogenesis of herpes simplex labialis: experimental induction of lesions with UV light, J. Clin. Microbiol., 22, 366, 10.1128/JCM.22.3.366-368.1985

Stadt, 1990, Occurrence of MRI abnormalities in patients with isolated optic neuritis, Eur. Neurol., 30, 305, 10.1159/000117361

Tisch, 1993, Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice, Nature, 366, 72, 10.1038/366072a0

Tovey, 1978, Activation of latent Epstein-Barr virus by antibody to human IgM, Nature, 276, 270, 10.1038/276270a0

van Eden, 1985, Arthritis induced by a T-lymphocyte clone that responds to mycobacterium tuberculosis and to cartilage proteoglycans, 82, 5117

van Eden, 1988, Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis, Nature, 331, 171, 10.1038/331171a0

Vogt, 1994, Ligand motifs of HLADRB5∗0101 and DRB1∗1501 molecules delineated from self-peptides, J. Immunol., 151, 1665, 10.4049/jimmunol.153.4.1665

Wekerle, 1986, Cellular immune reactivity within the CNS, Trends Neurosci., 9, 271, 10.1016/0166-2236(86)90077-9

Wucherpfennig, 1991, T-cell recognition of myelin basic protein, Immunol. Today, 12, 277, 10.1016/0167-5699(91)90126-E

Wucherpfennig, 1994, Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones, J. Exp. Med., 179, 279, 10.1084/jem.179.1.279

Wucherpfennig, 1994, Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide, J. Immunol., 150, 5581, 10.4049/jimmunol.152.11.5581

Zamvil, 1990, The T lymphocyte in experimental allergic encephalomyelitis, Annu. Rev. Immunol., 8, 579, 10.1146/annurev.iy.08.040190.003051

Zhang, 1994, Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis, J. Exp. Med., 179, 973, 10.1084/jem.179.3.973