Molecular mechanisms of estrogen action: selective ligands and receptor pharmacology
Tóm tắt
Từ khóa
Tài liệu tham khảo
Katzenellenbogen, 1996, Estrogen receptors: bioactivities and interactions with cell signaling pathways, Biol. Reprod., 54, 287, 10.1095/biolreprod54.2.287
Katzenellenbogen, 1997, Antiestrogens: mechanisms of action and resistance in breast cancer, Breast Cancer Res. Treat., 44, 23, 10.1023/A:1005835428423
Sarrel, 1994, Estrogen actions in arteries, bone and brain, Sci. Am. Sci. Med., 1, 44
Katzenellenbogen, 1996, Nuclear hormone receptors: ligand-activated regulators of transcription and diverse cell responses, Chem. Biol., 3, 529, 10.1016/S1074-5521(96)90143-X
Kuiper, 1998, Estrogen is a male and female hormone, Sci. Med., 5, 36
Katzenellenbogen, 1996, Tripartite steroid hormone receptor pharmacology: interaction with multiple effector sites as a basis for the cell- and promoter-specific action of these hormones, Mol. Endocrinol., 10, 119, 10.1210/me.10.2.119
Shibata, 1997, Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action, Recent Prog. Horm. Res., 52, 141
Mangelsdorf, 1995, The nuclear receptor superfamily: the second decade, Cell, 83, 835, 10.1016/0092-8674(95)90199-X
Horwitz, 1996, Nuclear receptor coactivators and corepressors, Mol. Endocrinol., 10, 1167, 10.1210/me.10.10.1167
Lieberherr, 1993, Cell signaling and estrogens in female rat osteoblasts: a possible involvement of unconventional nonnuclear receptors, J. Bone Miner. Res., 8, 1365, 10.1002/jbmr.5650081111
Migliaccio, 1996, Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiol-receptor complex in MCF-7 cells, EMBO J., 15, 1292, 10.1002/j.1460-2075.1996.tb00471.x
Improta-Brears, 1999, Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium [In Process Citation], Proc. Natl. Acad. Sci. USA, 96, 4686, 10.1073/pnas.96.8.4686
Razandi, 1999, Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: studies of ERα and ERβ expressed in chinese ovary cells, Mol. Endocrinol., 13, 307, 10.1210/me.13.2.307
Zheng, 1997, Demonstration of membrane estrogen binding proteins in rat brain by ligand blotting using a 17β-estradiol-[125I] bovine serum albumin conjugate, J. Steroid Biochem. Mol. Biol., 62, 327, 10.1016/S0960-0760(97)00037-X
Wrenn, 1993, Structure–function analysis of the hormone binding domain of the human estrogen receptor by region-specific mutagenesis and phenotypic screening in yeast, J. Biol. Chem., 268, 24089, 10.1016/S0021-9258(20)80497-9
Katzenellenbogen, 1993, Hormone binding and transcription activation by estrogen receptors: analyses using mammalian and yeast systems, J. Steroid Biochem. Mol. Biol., 47, 39, 10.1016/0960-0760(93)90055-2
Pakdel, 1992, Human estrogen receptor mutants with altered estrogen and antiestrogen ligand discrimination, J. Biol. Chem., 267, 3429, 10.1016/S0021-9258(19)50749-9
Harlow, 1989, Identification of cysteine-530 as the covalent attachment site of an affinity labeling estrogen (ketononestrol aziridine) and antiestrogen (tamoxifen aziridine) in the human estrogen receptor, J. Biol. Chem., 264, 17476, 10.1016/S0021-9258(18)71519-6
Reese, 1991, Mutagenesis of cysteines in the hormone binding domain of the human estrogen receptor: alterations in binding and transcriptional activation by covalently and reversibly attaching ligands, J. Biol. Chem., 266, 10880, 10.1016/S0021-9258(18)99101-5
Reese, 1992, Identification of two cysteines closely positioned in the ligand binding pocket of the human estrogen receptor: roles in ligand binding and transcriptional activation, Mol. Endocrinol., 6, 2160, 10.1210/me.6.12.2160
Pakdel, 1993, Identification of charged residues in an N-terminal portion of the hormone binding domain of the human estrogen receptor important in transcriptional activity of the receptor, Mol. Endocrinol, 7, 1408, 10.1210/me.7.11.1408
Ekena, 1996, Identification of amino acids in the hormone binding domain of the human estrogen receptor important in estrogen binding, J. Biol. Chem., 271, 20053, 10.1074/jbc.271.33.20053
Ekena, 1997, Different residues of the human estrogen receptor are involved in the recognition of structurally diverse estrogens and antiestrogens, J. Biol. Chem., 272, 5069, 10.1074/jbc.272.8.5069
Ekena, 1998, Determinants of ligand specificity of estrogen receptor-α estrogen versus androgen discrimination, J. Biol. Chem., 273, 693, 10.1074/jbc.273.2.693
Ince, 1993, Powerful dominant negative mutants of the human estrogen receptor, J. Biol. Chem., 268, 14026, 10.1016/S0021-9258(19)85204-3
Ince, 1995, Repression of endogenous estrogen receptor activity in MCF-7 human breast cancer cells by dominant negative estrogen receptors, Endocrinology, 136, 3194, 10.1210/en.136.8.3194
Lazennec, 1999, Adenovirus-mediated delivery of a dominant negative estrogen receptor gene abrogates estrogen-stimulated gene expression and breast cancer cell proliferation, Mol. Endocrinol., 13, 969, 10.1210/me.13.6.969
Weis, 1996, Constitutively active human estrogen receptors containing amino acid substitutions for tyrosine 537 in the receptor protein, Mol. Endocrinol., 10, 1388, 10.1210/me.10.11.1388
Lazennec, 1997, Mechanistic aspects of estrogen receptor activation probed with constitutively active estrogen receptors: correlations with DNA and coregulator interactions and receptor conformational changes, Mol. Endocrinol., 11, 1375, 10.1210/me.11.9.1375
White, 1997, Ligand-independent activation of the oestrogen receptor by mutation of a conserved tyrosine, EMBO J., 16, 1427, 10.1093/emboj/16.6.1427
Zhang, 1997, An estrogen receptor mutant with strong hormone-independent activity from a metastatic breast cancer, Cancer Res., 57, 1244
Tremblay, 1998, Ligand-independent activation of the estrogen receptors α and β by mutations of a conserved tyrosine can be abolished by antiestrogens, Cancer Res., 58, 877
Kuiper, 1996, Cloning of a novel estrogen receptor expressed in rat prostate and ovary, Proc. Natl. Acad. Sci. USA, 93, 5925, 10.1073/pnas.93.12.5925
Mosselman, 1996, ERβ: identification and characterization of a novel human estrogen receptor, FEBS Lett., 392, 49, 10.1016/0014-5793(96)00782-X
Katzenellenbogen, 1997, Editorial: a new actor in the estrogen receptor drama — enter ER-β, Endocrinology, 138, 861, 10.1210/en.138.3.861
Tzukerman, 1994, Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions, Mol. Endocrinol., 8, 21, 10.1210/me.8.1.21
Berry, 1990, Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen, EMBO J., 9, 2811, 10.1002/j.1460-2075.1990.tb07469.x
Montano, 1995, The carboxyl-terminal F domain of the human estrogen receptor: role in the transcriptional activity of the receptor and the effectiveness of antiestrogens as estrogen antagonists, Mol. Endocrinol., 9, 814, 10.1210/me.9.7.814
Kraus, 1995, Ligand-dependent; transcriptionally productive association of the amino- and carboxyl-terminal regions of a steroid hormone nuclear receptor, Proc. Natl. Acad. Sci. USA, 92, 12314, 10.1073/pnas.92.26.12314
McInerney, 1998, Transcription activation by the human estrogen receptor subtype β (ERβ) studied with ERβ and ERα receptor chimeras, Endocrinology, 139, 4513, 10.1210/en.139.11.4513
Kuiper, 1997, Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors α and β, Endocrinology, 138, 863, 10.1210/en.138.3.863
Sun, 1999, Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-α or estrogen receptor-β, Endocrinology, 140, 800, 10.1210/en.140.2.800
Meyers, 1999, Estrogen receptor subtype-selective ligands: asymmetric synthesis and biological evaluation of cis- and trans-5,11-eialkyl-5,6,11,12-tetrahydrochrysenes, J. Med. Chem., 42, 2456, 10.1021/jm990101b
Couse, 1999, Estrogen receptor null mice: what have we learned and where will they lead us?, Endocr. Rev., 20, 358, 10.1210/er.20.3.358
Lubahn, 1993, Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene, Proc. Natl. Acad. Sci. USA, 90, 11162, 10.1073/pnas.90.23.11162
Lemmen, 1999, Expression of estrogen receptor alpha and beta during mouse embryogenesis, Mech. Dev., 81, 163, 10.1016/S0925-4773(98)00223-8
Krege, 1998, Generation and reproductive phenotypes of mice lacking estrogen receptor β, Proc. Natl. Acad. Sci. USA, 95, 15677, 10.1073/pnas.95.26.15677
Iafrati, 1997, Estrogen inhibits the vascular injury response in estrogen receptor α-deficient mice, Nature Med., 3, 545, 10.1038/nm0597-545
Santen, 1990, Endocrine treatment of breast cancer in women, Endocr. Rev., 11, 221, 10.1210/edrv-11-2-221
Jordan, 1990, Endocrine pharmacology of antiestrogens as antitumor agents, Endocr. Rev., 11, 578, 10.1210/edrv-11-4-578
Schodin, 1995, Analysis of mechanisms that determine dominant negative estrogen receptor effectiveness, J. Biol. Chem., 270, 31163, 10.1074/jbc.270.52.31163
Brzozowski, 1997, Molecular basis of agonism and antagonism in the oestrogen receptor, Nature, 389, 753, 10.1038/39645
Montano, 1999, An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens, Proc. Natl. Acad. Sci. USA, 96, 6947, 10.1073/pnas.96.12.6947
Montano, 1997, The quinone reductase gene: a unique estrogen receptor-regulated gene that is activated by antiestrogens, Proc. Natl. Acad. Sci. USA, 94, 2581, 10.1073/pnas.94.6.2581
Montano, 1998, Transcriptional regulation of the human quinone reductase gene by antiestrogen-liganded estrogen receptor-α and estrogen receptor-β, J. Biol. Chem., 273, 25443, 10.1074/jbc.273.39.25443
Paech, 1997, Differential ligand activation of estrogen receptors ERα and ERβ at AP1 sites, Science, 277, 1508, 10.1126/science.277.5331.1508